Determination of urinary metabolites of cannabidiol, ?8-tetrahydrocannabinol, and ?9-tetrahydrocannabinol by automated online ?SPE-LC-MS/MS method

Article Biochemical Research Methods

Analytical and medico-legal problems linked to the presence of delta-8-tetrahydrocannabinol (delta-8-THC): Results from urine drug testing in Sweden

Anders Helander et al.

Summary: A new interfering peak was discovered during routine urine drug testing for cannabis at the Karolinska University Laboratory in Sweden, which was identified as delta-8-THC-COOH and caused analytical and medico-legal concerns.

DRUG TESTING AND ANALYSIS (2022)

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Article Chemistry, Analytical

An Enhanced LC-MS/MS Technique for Distinguishing Δ8- and Δ9-Tetrahydrocannabinol Isomers in Blood and Urine Specimens

Jami D. Reber et al.

Summary: This study describes a validated method to separate and quantify active Delta(8)-THC and Delta(9)-THC in blood while qualitatively confirming the inactive metabolites Delta(8)-THCCOOH and Delta(9)-THCCOOH in blood and urine.

JOURNAL OF ANALYTICAL TOXICOLOGY (2022)

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Article

Are adverse effects of cannabidiol (CBD) products caused by tetrahydrocannabinol (THC) contamination?

Dirk W. Lachenmeier et al.

F1000Research (2022)

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Article Chemistry, Analytical

Rapid and simple LC-MS/MS determination of urinary ethyl glucuronide, naltrexone, 6β-naltrexol, chlordiazepoxide, and norchlordiazepoxide for monitoring alcohol abuse

Yeong Eun Sim et al.

Summary: In this study, a LC-MS/MS method was developed to detect biomarkers for alcohol consumption and medications for alcohol dependence treatment. The method was successfully validated and can be used to monitor drug-based treatment of alcohol abuse and alcohol consumption during probation.

JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY (2022)

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Article Biochemical Research Methods

A validated method for the simultaneous quantification of cannabidiol, Δ9-tetrahydrocannabinol, and their metabolites in human plasma and application to plasma samples from an oral cannabidiol open-label trial

Richard C. Kevin et al.

Summary: In this study, a method for the simultaneous quantification of CBD, THC and their major Phase I metabolites was developed, optimized and validated according to FDA guidelines. The method is accurate, reproducible, sensitive, and can be carried out in high-throughput 96-well formats for larger scale clinical trials. Deuterated internal standards were crucial to account for variable matrix effects between plasma lots. The application of the method to plasma samples from individuals undergoing oral CBD treatment in an open-label trial of CBD effects in anxiety disorders demonstrated its immediate utility for ongoing and upcoming clinical trials, with potential to accommodate additional metabolites as analytical reference materials become commercially available.

DRUG TESTING AND ANALYSIS (2021)

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Article Chemistry, Analytical

Conversion of 7-Carboxy-Cannabidiol (7-COOH-CBD) to 11-Nor-9-Carboxy-Tetrahydrocannabinol (THC-COOH) during Sample Preparation for GC-MS Analysis

E. Dale Hart et al.

Summary: Research has shown that under laboratory conditions, 7-COOH-CBD does not produce false-positive results for THC-COOH, and no significant conversion of 7-COOH-CBD to THC-COOH was observed in NLCP-certified laboratories.

JOURNAL OF ANALYTICAL TOXICOLOGY (2021)

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Article Pharmacology & Pharmacy