Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1687, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2022.463650
Keywords
Sabia parviflora; UHPLC-Q-TOF-MS; MS; Cracking law; Composition analysis
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In this study, the chemical composition of Sabia parvi-flora was analyzed using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A rapid and accurate method, based on the characteristic ion filtration, was utilized to identify the chemical components, resulting in the identification of 104 components, including 12 potentially novel compounds. This method provides an important basis for basic chemical research in Sabia parvi-flora.
Effective and targeted identification of chemical components of the Chinese herbal medicine Sabia parvi-flora remains a major challenge. Herein, we used ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry to analyze the chemical composition of S.parviflora. Its chemical components were rapidly identified using the characteristic ion filtration method, which in-volves these steps: (1) summarize the characteristic ions based on similar skeletons and compounds with substitution patterns, and establish a database; (2) screen and classify different types of compounds in S. parviflora based on the characteristic ions; and (3) identify the compounds based on molecular weight, secondary fragments, and the database. In the present study, the characteristic ions in S. parviflora were grouped into five major classes. A total of 104 components were identified, including 12 potentially novel compounds. This rapid and accurate method provides an important basis for basic chemical research in S. parviflora.(c) 2022 Elsevier B.V. All rights reserved.
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