Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 43, Issue 3, Pages 476-478Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X221139550
Keywords
Cognitive fatigue; excitotoxicity; glutamate; magnetic resonance spectroscopy; neurotransmitter cycling
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Long-lasting activities with high demand in cognitive control result in cognitive fatigue, and the reason for control cost inflation is the necessity of recycling potentially toxic substances, specifically glutamate, which can accumulate extracellularly.
Long-lasting activities with high demand in cognitive control are known to result in cognitive fatigue. However, the reason for control cost inflation remains elusive. A neurometabolic account was proposed in a recent study combining magnetic resonance spectroscopy (MRS) with daylong execution of behavioral tasks. It suggests that control cost during high-demand work is related to the necessity of recycling potentially toxic substances, specifically glutamate, which may accumulate extracellularly. As MRS provides estimates of metabolite concentrations, further evaluations are possible how well this hypothesis fits with fundamental consequences from the dynamic equilibrium of intercompartmental glutamate distributions.
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