Complexity and self-organization in the evolution of cell polarization

Cellular life exhibits order and complexity, which typically increase over the course of evolution. Cell polarization is a well-studied example of an ordering process that breaks the internal symmetry of a cell by establishing a preferential axis. Like many cellular processes, polarization is driven by self-organization, meaning that the macroscopic pattern emerges as a consequence of microscopic molecular interactions at the biophysical level. However, the role of self-organization in the evolution of complex protein networks remains obscure. In this Review, we provide an overview of the evolution of polarization as a self-organizing process, focusing on the model species Saccharomyces cerevisiae and its fungal relatives. Moreover, we use this model system to discuss how self-organization might relate to evolutionary change, offering a shift in perspective on evolution at the microscopic scale.

Automated summary

Cell polarization is an important phenomenon in the evolution of cellular life, driven by self-organization and leading to the establishment of preferential axis. The evolution of polarization can be studied using Saccharomyces cerevisiae and its fungal relatives as model species, providing insights on the relationship between self-organization and evolutionary change at the microscopic scale.