Related references
Note: Only part of the references are listed.Exploring Mechanisms of Allosteric Regulation and Communication Switching in the Multiprotein Regulatory Complexes of the Hsp90 Chaperone with Cochaperones and Client Proteins: Atomistic Insights from Integrative Biophysical Modeling and Network Analysis of Conformational Landscapes
Gennady M. Verkhivker
JOURNAL OF MOLECULAR BIOLOGY (2022)
Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism
Ray Yu-Ruei Wang et al.
NATURE (2022)
Crystal structure of the middle and C-terminal domains of Hsp90α labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target
Shuxia Peng et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2022)
Advances towards Understanding the Mechanism of Action of the Hsp90 Complex
Chrisostomos Prodromou et al.
BIOMOLECULES (2022)
Role of HSP90 in Cancer
Bereket Birbo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network
Abraham Lopez et al.
SCIENCE ADVANCES (2021)
The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state
Kanghyun Lee et al.
MOLECULAR CELL (2021)
Hierarchical dynamics in allostery following ATP hydrolysis monitored by single molecule FRET measurements and MD simulations
Steffen Wolf et al.
CHEMICAL SCIENCE (2021)
Inhibitors of HSP90 in melanoma
Aleksandra Mielczarek-Lewandowska et al.
APOPTOSIS (2020)
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90
Sophie L. Mader et al.
NATURE COMMUNICATIONS (2020)
Post-translational modifications of Hsp90 and translating the chaperone code
Sarah J. Backe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Qianya Wan et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Hsp90 Quaternary Structures and the Chaperone Cycle: Highly Flexible Dimeric and Oligomeric Structures and Their Regulation by Co-Chaperones
Eleonore Lepvrier et al.
CURRENT PROTEOMICS (2019)
Structure, Function, and Regulation of the Hsp90 Machinery
Maximilian M. Biebl et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)
Regulation of the Hsp90 system
Siyuan Sima et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)
HullRad: Fast Calculations of Folded and Disordered Protein and Nucleic Acid Hydrodynamic Properties
Patrick J. Fleming et al.
BIOPHYSICAL JOURNAL (2018)
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
Len Neckers et al.
CELL STRESS & CHAPERONES (2018)
A switch point in the molecular chaperone Hsp90 responding to client interaction
Daniel Andreas Rutz et al.
NATURE COMMUNICATIONS (2018)
The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease
Abdullah Hoter et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
The HSP90 chaperone machinery
Florian H. Schopf et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation
Kourtney M. Goode et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)
Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?
Anuj Khandelwal et al.
MEDICINAL RESEARCH REVIEWS (2016)
Mechanisms of Hsp90 regulation
Chrisostomos Prodromou
BIOCHEMICAL JOURNAL (2016)
The HSP90 Molecular Chaperone-An Enigmatic ATPase
Laurence H. Pearl
BIOPOLYMERS (2016)
The epichaperome is an integrated chaperome network that facilitates tumour survival
Anna Rodina et al.
NATURE (2016)
A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response
Heather K. Armstrong et al.
PROSTATE (2016)
STRUCTURAL BIOLOGY Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase
Kliment A. Verba et al.
SCIENCE (2016)
Hsp90 Oligomers Interacting with the Aha1 Cochaperone: An Outlook for the Hsp90 Chaperone Machineries
Eleonore Lepvrier et al.
ANALYTICAL CHEMISTRY (2015)
Hsp90 oligomerization process: How can p23 drive the chaperone machineries?
Eleonore Lepyrier et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2015)
Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions
David S. Hong et al.
CANCER TREATMENT REVIEWS (2013)
Hsp90 structure and function studied by NMR spectroscopy
Tatiana Didenko et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones
Jing Li et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
Jeffery D. Eskew et al.
BMC CANCER (2011)
The Hexameric Structures of Human Heat Shock Protein 90
Cheng-Chung Lee et al.
PLOS ONE (2011)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Biochemical and Biophysical Characterization of the Mg2+-induced 90-kDa Heat Shock Protein Oligomers
Laura Moullintraffort et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Targeting the dynamic HSP90 complex in cancer
Jane Trepel et al.
NATURE REVIEWS CANCER (2010)
Apo-Hsp90 coexists in two open conformational states in solution
Patrick Bron et al.
BIOLOGY OF THE CELL (2008)
Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines
Joseph A. Burlison et al.
JOURNAL OF ORGANIC CHEMISTRY (2008)
Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle
Daniel R. Southworth et al.
MOLECULAR CELL (2008)
Multiple conformations of E-coli Hsp90 in solution:: Insights into the conformational dynamics of Hsp90
Kristin A. Krukenberg et al.
STRUCTURE (2008)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
The middle domain of Hsp90 acts as a discriminator between different types of client proteins
Patricija Hawle et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Structural analysis of E-coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
Andrew K. Shiau et al.
CELL (2006)
HKL-3000:: the integration of data reduction and structure solution -: from diffraction images to an initial model in minutes
Wladek Minor et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
MMU Ali et al.
NATURE (2006)
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion
J Painter et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions
E Krissinel et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
A Kamal et al.
NATURE (2003)