4.5 Article

2D MXenes for controlled releases of therapeutic proteins

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Multiple Stimuli-Responsive MXene-Based Hydrogel as Intelligent Drug Delivery Carriers for Deep Chronic Wound Healing

Xin Yang et al.

Summary: A novel MXene-based hydrogel drug delivery system for efficient treatment of deep chronic wounds is introduced in the study. This system demonstrates multiple response capability and controllable drug delivery ability, reducing toxic side effects of drugs and promoting wound healing process. The practical performance of the system in treating rat models indicates great prospect in clinical wound healing and related biomedical fields.

SMALL (2022)

Article Nanoscience & Nanotechnology

A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

Xiaoge Zhang et al.

Summary: In this study, a camouflaged bionic cascaded-enzyme nanoreactor was designed for efficient tumor treatment through a series of enzymatic reactions, phototherapy, and deoxygenation-activated chemotherapy. The nanoreactor exhibited biomimetic membrane camouflage and CD47 overexpression, which enhanced tumor targeting and immune escape capabilities.

NANO-MICRO LETTERS (2022)

Review Pharmacology & Pharmacy

Two-dimensional (2D) materials beyond graphene in cancer drug delivery, photothermal and photodynamic therapy, recent advances and challenges ahead: A review

Mohammad Jafar Molaei

Summary: Various 2D materials with superior properties have been developed for biomedical and cancer therapy applications, such as TMDs, BN, MXenes, LDHs, and BP nanosheets. These materials are used for drug delivery, bioimaging, photothermal therapy, and other applications in cancer treatment.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

Review Environmental Sciences

Cytotoxicity of MXene-based nanomaterials for biomedical applications: A mini review

Gim Pao Lim et al.

Summary: MXene based nanomaterial is a promising two-dimensional material with versatile properties for applications in electronic devices, power generation, sensors, drug delivery, and biomedicine. However, its cytotoxic effects remain a major concern, with biocompatibility and cytotoxicity depending largely on its physicochemical properties, size, dose, and surface coating. Various in vitro and in vivo studies have been conducted to investigate the interactions between MXene and living organisms, with machine learning methods also being developed to predict cytotoxicity. Current research also focuses on addressing the cytotoxicity of MXene for biomedical interventions.

ENVIRONMENTAL RESEARCH (2021)

Article Engineering, Environmental

2D Ti3C2Tx MXene nanosheets coated cellulose fibers based 3D nanostructures for efficient water desalination

Shoaib Anwer et al.

Summary: A novel and facile synthesis strategy was introduced to design 2D MXene nanosheets coated cellulose fibers based 3D nanostructures, overcoming the drawbacks in commonly used CDI electrodes and MXene based electrodes. The CLF@Ti3C2Tx based active electrodes exhibited good specific capacitance and high salt adsorption capacitance in 1M sodium chloride electrolyte, with considerable cycling stability.

CHEMICAL ENGINEERING JOURNAL (2021)

Review Engineering, Biomedical

MXene in the lens of biomedical engineering: synthesis, applications and future outlook

Adibah Zamhuri et al.

Summary: MXene is a multifaceted 2D material with unique physicochemical properties and biocompatibility, suitable for applications in biomedicine and biotechnology such as drug delivery and bio-imaging.

BIOMEDICAL ENGINEERING ONLINE (2021)

Article Materials Science, Ceramics

In-situ self-assembly of sandwich-like Ti3C2 MXene/gold nanorods nanosheets for synergistically enhanced near-infrared responsive drug delivery

Beibei Zhu et al.

Summary: This paper presents a method for preparing intelligent nanohybrids combining gold nanorods with Ti3C2 nanosheets, exhibiting excellent photothermal conversion efficiency, drug loading capacity, and responsive drug release properties under NIR irradiation.

CERAMICS INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Chitosan/hyaluronic acid based hollow microcapsules equipped with MXene/gold nanorods for synergistically enhanced near infrared responsive drug delivery

Zheng Wu et al.

Summary: In this study, a pH/NIR multi-responsive drug delivery platform was successfully fabricated using a layer-by-layer approach, consisting of hollow hydroxyapatite, chitosan/hyaluronic acid multilayers, gold nanorods, and MXene. The system exhibited excellent photothermal conversion efficiency and biocompatibility, with outstanding drug release performance under acidic conditions and effective activation by near-infrared light.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Materials Science, Multidisciplinary

Characterization of MXenes at every step, from their precursors to single flakes and assembled films

Mikhail Shekhirev et al.

Summary: The field of MXene continues to grow as more research groups investigate this large class of 2D materials. While synthesis and applications have been widely discussed, the importance of characterization is often overlooked. This review focuses on various advanced characterization techniques for understanding the precursor suitability, successful synthesis, composition, structure, and properties of MXene.

PROGRESS IN MATERIALS SCIENCE (2021)

Article Chemistry, Physical

A Comparative Study of Cytotoxicity of PPG and PEG Surface-Modified 2-D Ti3C2 MXene Flakes on Human Cancer Cells and Their Photothermal Response

Bushra Rashid et al.

Summary: This study found that surface-modified MXenes exhibited significant reduction in cell viability for both normal and cancer cell lines, with more pronounced cytotoxicity towards cancer cells. PEGylated MXene showed slightly lower toxicity towards normal cells compared to PPGylated MXene, but comparable toxicity towards malignant cells, making it a relatively safe and effective anticancer agent.

MATERIALS (2021)

Article Nanoscience & Nanotechnology

Natural Polymers Decorated MOF-MXene Nanocarriers for Co-delivery of Doxorubicin/pCRISPR

Navid Rabiee et al.

Summary: A one-pot and facile method with assistance of high gravity was used to synthesize inorganic nanostructures for efficient co-delivery of drug and gene. The bioavailability and interaction with pCRISPR was enhanced by coating the nanomaterial with alginate and chitosan, leading to excellent cell viability and comprehensive cytotoxicity studies. The polymer-coated nanosystems showed superior relative cell viability, with chitosan-coated nanocarriers demonstrating over 60% relative cell viability on average across all cell lines.

ACS APPLIED BIO MATERIALS (2021)

Review Polymer Science

Polymer scaffolds as drug delivery systems

Italo Rodrigo Calori et al.

EUROPEAN POLYMER JOURNAL (2020)

Article Nanoscience & Nanotechnology

Tensile behaviors of Ti3C2Tx(MXene) films

Shaohong Luo et al.

NANOTECHNOLOGY (2020)

Article Materials Science, Biomaterials

A simple, low-cost and green method for controlling the cytotoxicity of MXenes

A. Rozmyslowska-Wojciechowska et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Review Engineering, Biomedical

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Hua Zhang et al.

BIOACTIVE MATERIALS (2020)

Article Materials Science, Biomaterials

Two-dimensional MXene/cobalt nanowire heterojunction for controlled drug delivery and chemo-photothermal therapy

Yunxiu Liu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

Article Nanoscience & Nanotechnology

Optimization of Gold Nanoparticles for Efficient Delivery of Catalase to Macrophages for Alleviating Inflammation

Fatima Ba Fakih et al.

ACS APPLIED NANO MATERIALS (2020)

Review Pharmacology & Pharmacy

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Bahman Homayun et al.

PHARMACEUTICS (2019)

Review Materials Science, Ceramics

Synthesis, structure, properties and applications of MXenes: Current status and perspectives

Rodrigo Mantovani Ronchi et al.

CERAMICS INTERNATIONAL (2019)

Editorial Material Chemistry, Multidisciplinary

The Rise of MXenes

Yury Gogotsi et al.

ACS NANO (2019)

Review Cell Biology

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

Ankita Nandi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Engineering, Biomedical

Promoting Role of MXene Nanosheets in Biomedical Sciences: Therapeutic and Biosensing Innovations

Mohammadreza Soleymaniha et al.

ADVANCED HEALTHCARE MATERIALS (2019)

Article Chemistry, Multidisciplinary

2D MXene Nanofilms with Tunable Gas Transport Channels

Jie Shen et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

Review Pharmacology & Pharmacy

The challenges of oral drug delivery via nanocarriers

Jonas Reinholz et al.

DRUG DELIVERY (2018)

Article Materials Science, Ceramics

Carbon dioxide adsorption of two-dimensional carbide MXenes

Bingxin Wang et al.

JOURNAL OF ADVANCED CERAMICS (2018)

Article Engineering, Environmental

In vitro studies on cytotoxicity of delaminated Ti3C2 MXene

A. M. Jastrzebska et al.

JOURNAL OF HAZARDOUS MATERIALS (2017)

Article Chemistry, Physical

Guidelines for Synthesis and Processing of Two-Dimensional Titanium Carbide (Ti3C2TX MXene)

Mohamed Alhabeb et al.

CHEMISTRY OF MATERIALS (2017)

Article Chemistry, Multidisciplinary

Flexible MXene/Graphene Films for Ultrafast Supercapacitors with Outstanding Volumetric Capacitance

Jun Yan et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Review Cell Biology

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

Long He et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

Review Pharmacology & Pharmacy

Challenges in oral drug delivery of antiretrovirals and the innovative strategies to overcome them

Alejandro Sosnik et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Chemistry, Multidisciplinary

25th Anniversary Article: MXenes: A New Family of Two-Dimensional Materials

Michael Naguib et al.

ADVANCED MATERIALS (2014)

Article Chemistry, Multidisciplinary

Cytotoxicity and immune response of CdSe/ZnS Quantum dots towards a murine macrophage cell line

Guimiao Lin et al.

RSC ADVANCES (2014)

Article Pharmacology & Pharmacy

Zein-based oral drug delivery system targeting activated macrophages

Sungmun Lee et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Review Chemistry, Multidisciplinary

Biocompatibility of engineered nanoparticles for drug delivery

Sheva Naahidi et al.

JOURNAL OF CONTROLLED RELEASE (2013)

Review Pharmacology & Pharmacy

Nanocarriers for oral drug delivery

Lin Zhang et al.

JOURNAL OF DRUG TARGETING (2013)

Article Instruments & Instrumentation

SEM sample preparation for cells on 3D scaffolds by freeze-drying and HMDS

Juliana Tsz Yan Lee et al.

SCANNING (2012)

Article Chemistry, Multidisciplinary

Two-Dimensional Nanocrystals Produced by Exfoliation of Ti3AlC2

Michael Naguib et al.

ADVANCED MATERIALS (2011)

Review Pharmacology & Pharmacy

Polymer-based nanocapsules for drug delivery

C. E. Mora-Huertas et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Review Pharmacology & Pharmacy

Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

Makiya Nishikawa et al.

ADVANCED DRUG DELIVERY REVIEWS (2009)

Article Biochemistry & Molecular Biology

Targeted delivery of catalase and superoxide dismutase to macrophages using folate

Sungmun Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)