4.6 Article

Extracellular intersubunit interactions modulate epithelial Na plus channel gating

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Accessibility of ENaC extracellular domain central core residues

Lei Zhang et al.

Summary: This study used cysteine-scanning mutagenesis to assess the functional effects of Cys-modifying reagents on the palm domain beta 10 strand residues in mouse ENaC. The results suggest that the proximal regions of beta 10 strands in all three subunits are accessible to small aqueous compounds and Cd(2+) and have a role in modulating ENaC gating.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Physiology

Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology

David Pearce et al.

Summary: Regulated Na+ transport in the distal nephron is crucial for fluid and electrolyte homeostasis, controlling the levels and concentrations of various ions. Recent research has provided a clearer understanding of the transporters involved in moving Na+ in the distal nephron and their relationships with other ions, as well as the roles of signaling systems and components. Emerging evidence suggests that local K+ concentrations are involved in the reciprocal regulation of NCC and ENaC activity, adjusting renal K+ secretion in response to dietary intake.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2022)

Review Peripheral Vascular Disease

Epithelial Sodium Channel and Salt-Sensitive Hypertension

Stephanie M. Mutchler et al.

Summary: The development of high blood pressure is influenced by genetic and environmental factors, with high salt intake being a known environmental contributor. There is a spectrum of sodium-sensitivity among individuals, partly due to genetic variation in pathways involved in sodium handling and excretion. ENaC plays a crucial role in regulating extracellular fluid volume and blood pressure by facilitating sodium reabsorption in the distal nephron.

HYPERTENSION (2021)

Article Physiology

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1

Matthew L. Rook et al.

Summary: Desensitization is a common feature in ASIC ion channels, but the Q276G mutation does not have a significant impact in both human and chicken ASIC1, showing unexpected differences compared to previous findings.

JOURNAL OF GENERAL PHYSIOLOGY (2021)

Review Pharmacology & Pharmacy

A molecular view of the function and pharmacology of acid-sensing ion channels

Sabrina Vullo et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Cell Biology

Regulating ENaC's gate

Thomas R. Kleyman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2020)

Review Peripheral Vascular Disease

ENaC in Salt-Sensitive Hypertension: Kidney and Beyond

Ashley L. Pitzer et al.

CURRENT HYPERTENSION REPORTS (2020)

Article Biochemistry & Molecular Biology

Analyses of epithelial Na+ channel variants reveal that an extracellular ?-ball domain critically regulates ENaC gating

Xueqi Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Urology & Nephrology

New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature

Stephanie M. Mutchler et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2019)

Review Physiology

Epithelial Na+ Channel Regulation by Extracellular and Intracellular Factors

Thomas R. Kleyman et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Article Biochemistry & Molecular Biology

Thumb domains of the three epithelial Na+ channel subunits have distinct functions

Shaohu Sheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Gating mechanisms of acid-sensing ion channels

Nate Yoder et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit

Shujie Shi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Physiology

Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity

Evan C. Ray et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain

Jingxin Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans

Yushu Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Na+ Inhibits the Epithelial Na+ Channel by Binding to a Site in an Extracellular Acidic Cleft

Ossama B. Kashlan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Reversible Cysteine Oxidation in Hydrogen Peroxide Sensing and Signal Transduction

Sarela Garcia-Santamarina et al.

BIOCHEMISTRY (2014)

Article Physiology

Intersubunit conformational changes mediate epithelial sodium channel gating

Daniel M. Collier et al.

JOURNAL OF GENERAL PHYSIOLOGY (2014)

Review Urology & Nephrology

Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells

David G. Warnock et al.

NATURE REVIEWS NEPHROLOGY (2014)

Review Medical Laboratory Technology

The renal channelopathies

K. W. Loudon et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2014)

Article Physiology

Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module

Jingxin Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)

Article Biochemistry & Molecular Biology

Molecular determinants of desensitization in an ENaC/degenerin channel

Sophie Roy et al.

FASEB JOURNAL (2013)

Review Biochemistry & Molecular Biology

The Redox Biochemistry of Protein Sulfenylation and Sulfinylation

Mauro Lo Conte et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Physiology

Gain-of-function variant of the human epithelial sodium channel

Jingxin Chen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Identification of Extracellular Domain Residues Required for Epithelial Na+ Channel Activation by Acidic pH

Daniel M. Collier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Extracellular Finger Domain Modulates the Response of the Epithelial Sodium Channel to Shear Stress

Shujie Shi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Role of the Wrist Domain in the Response of the Epithelial Sodium Channel to External Stimuli

Shujie Shi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Inhibitory Tract Traps the Epithelial Na+ Channel in a Low Activity Conformation

Ossama B. Kashlan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Probing the Structural Basis of Zn2+ Regulation of the Epithelial Na+ Channel

Jingxin Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Physiology

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site

Christopher J. Passero et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition

Raul Molina et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)

Article Biochemistry & Molecular Biology

Identification of Epithelial Na+ Channel (ENaC) Intersubunit Cl- Inhibitory Residues Suggests a Trimeric αγβ Channel Architecture

Daniel M. Collier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

External Cu2+ Inhibits Human Epithelial Na+ Channels by Binding at a Subunit Interface of Extracellular Domains

Jingxin Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Base of the Thumb Domain Modulates Epithelial Sodium Channel Gating

Shujie Shi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Extracellular Allosteric Regulatory Subdomain within the γ Subunit of the Epithelial Na+ Channel

Katie L. Winarski et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Allosteric Inhibition of the Epithelial Na+ Channel through Peptide Binding at Peripheral Finger and Thumb Domains

Ossama B. Kashlan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Role of Epithelial Sodium Channels and Their Regulators in Hypertension

Rama Soundararajan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Physiology

8-pCPT-cGMP stimulates αβγ-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties

Hong-Guang Nie et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2010)

Article Biochemistry & Molecular Biology

Extracellular Protons Regulate Human ENaC by Modulating Na+ Self-inhibition

Daniel M. Collier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Novel Determinants of Epithelial Sodium Channel Gating within Extracellular Thumb Domains

Ahmad B. Maarouf et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Extracellular Chloride Regulates the Epithelial Sodium Channel

Daniel M. Collier et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Plasmin Activates Epithelial Na+ Channels by Cleaving the γ Subunit

Christopher J. Passero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Physiology

A segment of γ ENaC mediates elastase activation of Na+ transport

Adedotun Adebamiro et al.

JOURNAL OF GENERAL PHYSIOLOGY (2007)

Article Multidisciplinary Sciences

Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH

Jayasankar Jasti et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition

Shaohu Sheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Physiology

Effect of divalent heavy metals on epithelial Na+ channels in A6 cells

Ling Yu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the γ-subunit

James B. Bruns et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its α subunit

Marcelo D. Carattino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Physiology

Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition

S Sheng et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)

Article Physiology

Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport

RA Caldwell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Biochemistry & Molecular Biology

Epithelial sodium channels are activated by furin-dependent proteolysis

RP Hughey et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels

SH Sheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Epithelial Na+ channels are activated by laminar shear stress

MD Carattino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition

SH Sheng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Cell Biology

Serine protease activation of near-silent epithelial Na+ channels

RA Caldwell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

Article Multidisciplinary Sciences

MEC-2 regulates C-elegans DEG/ENaC channels needed for mechanosensation

MB Goodman et al.

NATURE (2002)

Article Physiology

Epithelial Na+ channels are regulated by flow

LM Satlin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2001)