4.6 Article

Hydroxylation site-specific and production-dependent effects of endogenous oxysterols on cholesterol homeostasis: Implications for SREBP-2 and LXR

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Oxysterols: From physiological tuners to pharmacological opportunities

Andrew J. Brown et al.

Summary: Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals and enzymes, playing key roles in health and disease through binding to effector proteins and regulating transcriptional programmes affecting cell metabolism and function at low concentrations in vivo.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2 alpha-ATF4 axis

Yuichi Watanabe et al.

Summary: The INSIGs proteins regulate cholesterol metabolism in the endoplasmic reticulum, and interaction with certain oxysterols can increase ATF4 protein expression, leading to the upregulation of cell death-inducible genes and promotion of cell death.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Michael S. Brown et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Review Endocrinology & Metabolism

Sterol Metabolism and Transport in Atherosclerosis and Cancer

Yoshio Yamauchi et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

On the regulatory importance of 27-hydroxycholesterol in mouse liver

Maura Heverin et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Review Endocrinology & Metabolism

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology

Hitoshi Shimano et al.

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Biochemistry & Molecular Biology

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

Eric V. Dang et al.

Article Biochemistry & Molecular Biology

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis

Yoshio Yamauchi et al.

JOURNAL OF LIPID RESEARCH (2016)

Review Cell Biology

Structure and function of ER membrane contact sites with other organelles

Melissa J. Phillips et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Re-adopting classical nuclear receptors by cholesterol metabolites

Michihisa Umetani

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Oxysterols: From cholesterol metabolites to key mediators

Valentin Mutemberezi et al.

PROGRESS IN LIPID RESEARCH (2016)

Review Biochemistry & Molecular Biology

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Joseph L. Goldstein et al.

Article Biochemistry & Molecular Biology

Deficiency in the Lipid Exporter ABCA1 Impairs Retrograde Sterol Movement and Disrupts Sterol Sensing at the Endoplasmic Reticulum

Yoshio Yamauchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Endocrinology & Metabolism

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

Rucha Patel et al.

MOLECULAR ENDOCRINOLOGY (2015)

Article Biochemistry & Molecular Biology

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1

Sandeep Goyal et al.

JOURNAL OF LIPID RESEARCH (2014)

Review Immunology

25-Hydroxycholesterols in innate and adaptive immunity

Jason G. Cyster et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Article Medicine, General & Internal

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

M. Shafaati et al.

JOURNAL OF INTERNAL MEDICINE (2011)

Review Biochemistry & Molecular Biology

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

Michael S. Brown et al.

JOURNAL OF LIPID RESEARCH (2009)

Article Biochemistry & Molecular Biology

Are side-chain oxidized oxysterols regulators also in vivo?

Ingemar Bjorkhem

JOURNAL OF LIPID RESEARCH (2009)

Article Multidisciplinary Sciences

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

David R. Bauman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Direct Interaction of Nuclear Liver X Receptor-β with ABCA1 Modulates Cholesterol Efflux

Masako Hozoji et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised

Saloni Gill et al.

PROGRESS IN LIPID RESEARCH (2008)

Article Biochemistry & Molecular Biology

Endogenous 24(S),25-epoxycholesterol fine-tunes acute control of cellular cholesterol homeostasis

Jenny Wong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

Arun Radhakrishnan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands

Chendong Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Isolation of sterol-resistant Chinese hamster ovary cells with genetic deficiencies in both Insig-1 and Insig-2

PCW Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and insigs

CM Adams et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

PJ Espenshade et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation

R Arakawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells

X Fu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Multidisciplinary Sciences

Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands

RA DeBose-Boyd et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Biochemistry & Molecular Biology

Oxysterol biosynthetic enzymes

DW Russell

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)

Article Biochemistry & Molecular Biology

Disruption of the oxysterol 7α-hydroxylase gene in mice

J Li-Hawkins et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)