A comparison between the Felix™ electrophoretic system of sperm isolation and conventional density gradient centrifugation: a multicentre analysis

Article Obstetrics & Gynecology

Microfluidic preparation of spermatozoa for ICSI produces similar embryo quality to density-gradient centrifugation: a pragmatic, randomized controlled trial

Molly M. Quinn et al.

Summary: There was no significant difference in embryo quality, clinical pregnancy rates, and ongoing pregnancy rates between using a microfluidic sperm separation device and density-gradient centrifugation in IVF with ICSI.

HUMAN REPRODUCTION (2022)

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Article Endocrinology & Metabolism

Cumulative live birth rates after IVF/ICSI cycles with sperm prepared by density gradient centrifugation vs. swim-up: a retrospective study using a propensity score-matching analysis

Meng Rao et al.

Summary: This retrospective study compared the effects of density gradient centrifugation (DGC) and swim-up (SU) on the outcomes of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). After matching and adjustment, no significant differences were found between the DGC and SU groups in terms of sperm recovery rate, progressive motility rate, fertilization rate, embryo quality, and blastocyst formation rate. The cumulative live birth rate and live birth rate per transfer were also not significantly different between the groups. However, the DGC group had a significantly higher fertilization rate when using poor-quality sperm compared to the SU group.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2022)

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Article Obstetrics & Gynecology

Longitudinal semen parameter assessments and live birth : variability and implications for treatment

Elizabeth A. DeVilbiss et al.

Summary: This study examined the association between semen parameters and live birth in couples seeking infertility treatment. The findings suggest that low morphology, motility, concentration, and total motile count are associated with fewer live births in couples undergoing ovulation induction or no treatment. For intrauterine insemination, low volume, concentration, count, and total motile count are associated with fewer live births. Only low morphology is important for live birth after in vitro fertilization.

FERTILITY AND STERILITY (2022)

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Article Obstetrics & Gynecology

A Simple, Centrifugation-Free, Sperm-Sorting Device Eliminates the Risks of Centrifugation in the Swim-Up Method While Maintaining Functional Competence and DNA Integrity of Selected Spermatozoa

Huidrom Yaiphaba Meitei et al.

Summary: This pilot study showed that a device based on migration-sedimentation (MS) technique can provide higher sperm viability, longer motility, and better mitochondrial integrity in sperm selection compared to centrifugation-based techniques. The device also effectively reduces sperm DNA damage. It is centrifugation-free and suitable for partially equipped IUI laboratories or office programs.

REPRODUCTIVE SCIENCES (2021)

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Article Obstetrics & Gynecology