Evaluation of HIV-1 capsid genetic variability and lenacapavir (GS-6207) drug resistance-associated mutations according to viral clades among drug-naive individuals

Article Infectious Diseases

Phenotypic resistance to lenacapavir and monotherapy efficacy in a proof-of-concept clinical study

Nicolas Margot et al.

Summary: Through in vitro and clinical assays, this study found that mutations in HIV-1 capsid protein are associated with increased resistance to Lenacapavir, but also decreased replication capacity of the mutant viruses. In the clinical trial, all participants who received Lenacapavir treatment showed a robust virological response without any detected resistance mutations.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2022)

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Editorial Material Medicine, General & Internal

Lenacapavir effective in multidrug-resistant HIV infections

Susanne Krome

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT (2022)

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Article Microbiology

HIV Capsid Protein Genetic Diversity Across HIV-1 Variants and Impact on New Capsid-Inhibitor Lenacapavir

Paloma Troyano-Hernaez et al.

Summary: The HIV-1 p24 protein plays a crucial role in the viral replication cycle and is important for vaccine design and antiretroviral drug development. This study analyzed the diversity of p24 among different HIV-1 variants and within its secondary structure. The results showed variations in conservation among different variants and secondary structure types, with overall high conservation. These findings provide valuable information for understanding the variability of p24 and developing effective strategies against HIV-1.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Medicine, General & Internal

Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection

Sorana Segal-Maurer et al.

Summary: Patients with multidrug-resistant HIV-1 infection showed greater reduction in viral load when treated with lenacapavir compared to placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Microbiology

Absence of Lenacapavir (GS-6207) Phenotypic Resistance in HIV Gag Cleavage Site Mutants and in Isolates with Resistance to Existing Drug Classes

Nicolas Margot et al.

Summary: LEN is a potent inhibitor of HIV-1 capsid and has shown strong antiviral response in mutants with Gag cleavage site mutations and resistance to other drug classes. While LEN demonstrated wild-type susceptibility, reduced susceptibility was observed for control drugs.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

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Review Virology

HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules

Akatsuki Saito et al.

Summary: The HIV-1 capsid protein plays a crucial role in viral replication and is being explored as a potential therapeutic target. Host factors can interact with the capsid protein to affect infection, and extensive research has been conducted on the diversity and interactions of viral capsids with host molecules. This understanding of the sequence-function relationship of the capsid protein contributes to our knowledge of the adaptive potential of the viral capsid.

RETROVIROLOGY (2021)

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Review Biology

Structure, Function, and Interactions of the HIV-1 Capsid Protein

Eric Rossi et al.

Summary: The capsid (CA) protein of HIV-1 plays crucial roles in shielding the reverse transcription complex, facilitating trafficking to the nucleus, and forming the capsid core during viral maturation. Understanding the functions of CA could lead to the development of potential therapeutic targets for HIV-1 inhibitors.

LIFE-BASEL (2021)

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Article Immunology