An update on anaphylaxis and urticaria

Article Dermatology

GWAS of Chronic Spontaneous Urticaria Reveals Genetic Overlap with Autoimmune Diseases, Not Atopic Diseases

Liming Zhang et al.

Summary: This study identifies five risk loci for chronic spontaneous urticaria (CSU) through GWAS analysis in Chinese Han adults, and reveals genetic overlap between CSU and autoimmune diseases.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2023)

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Article Allergy

An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria

Sabine Altrichter et al.

Summary: This study aimed to evaluate the safety and efficacy of Lirentelimab in patients with chronic urticaria. The results showed that Lirentelimab could improve symptoms and reduce disease activity, demonstrating good clinical efficacy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Letter Dermatology

Lack evidence of association of PTPN-22 and CTLA-4 polymorphisms with risk of chronic spontaneous urticaria in Han Chinese population

Nan Lu et al.

JOURNAL OF COSMETIC DERMATOLOGY (2022)

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Article Allergy

The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Torsten Zuberbier et al.

Summary: The updated international guideline for urticaria was developed jointly by multiple international organizations, with participants from 50 countries and international societies, aiming to provide expert guidance on diagnostic and therapeutic approaches for different subtypes of urticaria.

ALLERGY (2022)

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Article Allergy

Combining Anti-IgE Monoclonal Antibodies and Oral Immunotherapy for the Treatment of Food Allergy

Laurent Guilleminault et al.

Summary: Food allergy, especially in children, poses a significant public health challenge globally, with limited treatment options available. Combining oral immunotherapy with omalizumab may represent a safer approach in managing severe food allergy cases, offering potential benefits in terms of safety, efficacy, and quality of life improvement.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Article Allergy

Food-dependent and food-exacerbated symptomatic dermographism: New variants of symptomatic dermographism

Muhammed Burak Yucel et al.

Summary: The intake of food may affect the symptoms and disease activity of symptomatic dermographism (SD). Two previously unknown subtypes of SD, food-exacerbated SD and food-dependent SD, are described in this study.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Allergy

Autoimmune chronic spontaneous urticaria

Pavel Kolkhir et al.

Summary: Chronic spontaneous urticaria (CSU) is a mast cell-driven disease characterized by recurrent wheals and/or angioedema, with two main autoimmune mechanisms: type I autoallergic CSU and type IIb autoimmune CSU. The latter is less common but more severe, and new targeted therapies are under development for CSU treatment.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Medicine, Research & Experimental

Serological profiling reveals hsa-miR-451a as a possible biomarker of anaphylaxis

Wojciech Francuzik et al.

Summary: This study aimed to investigate serum biomarker profiles (proteins, lipids, and miRNAs) to support the diagnosis of anaphylaxis. It was found that hsa-miR-451a was elevated during anaphylaxis and could serve as a significant biomarker. Additionally, combining multiple biomarkers improved the accuracy of diagnosing patients with anaphylaxis.

JCI INSIGHT (2022)

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Review Allergy

Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?

Susanne Radonjic-Hoesli et al.

Summary: With the development of targeted therapies for allergic diseases, the need for biomarkers supporting disease diagnosis and management has increased. Recent research has shed light on the role of cytokines in the pathogenesis of allergic diseases, suggesting their potential as biomarkers. This review article summarizes published findings and critically discusses the use of cytokine measurements in disease diagnosis and management. Thymus and activation-regulated chemokine (TARC) stands out as a biomarker for atopic dermatitis. However, both biological characteristics and technical issues affect the reliability and limit the use of blood cytokines as biomarkers.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Review Medicine, General & Internal

Monoclonal Antibodies in Treating Chronic Spontaneous Urticaria: New Drugs for an Old Disease

Sara Manti et al.

Summary: Omalizumab remains the best choice for treating refractory CSU, but some patients remain unresponsive. Other mAbs targeting different pathways have shown promising results, but further RCTs are needed to confirm their effectiveness and safety.

JOURNAL OF CLINICAL MEDICINE (2022)

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Editorial Material Allergy

Concise update on the pathogenesis of chronic spontaneous urticaria (CSU)

Michihiro Hide et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions

Janina Petry et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Phenotype and risk factors of venom-induced anaphylaxis: A case-control study of the European Anaphylaxis Registry

Wojciech Francuzik et al.

Summary: The study evaluated the phenotype and risk factors of venom-induced anaphylaxis (VIA) using data from the European Anaphylaxis Registry. VIA more frequently involved multiple organ systems and was associated with cardiovascular symptoms, while the absence of skin symptoms during anaphylaxis was correlated with a higher risk of severe reactions. Patients with intermediate baseline serum tryptase levels and without skin involvement had a higher risk of severe VIA. Patients receiving beta-blockers or angiotensin-converting enzyme inhibitors had a higher risk of developing severe cardiovascular symptoms in VIA and non-VIA cases, where patients experiencing VIA received epinephrine less frequently than cases with non-VIA.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1

Jonathan J. Lyons et al.

Summary: This study revealed that genotypes have a significant impact on the severity of anaphylaxis in humans, particularly in association with H alpha T. The prevalence of H alpha T was higher in healthy individuals and controls with nonatopic disease, and it was particularly prominent in systemic mastocytosis and idiopathic anaphylaxis, suggesting it as a potential risk factor for severe allergic reactions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians

Chuang-Wei Wang et al.

Summary: The study identified HLA-B*13:01 as an important genetic factor associated with co-trimoxazole-induced severe cutaneous adverse reactions (SCAR) in Asians.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Cardiovascular changes during peanut-induced allergic reactions in human subjects

Monica Ruiz-Garcia et al.

Summary: A systematic evaluation of cardiovascular changes during acute allergic reactions to peanut showed significant fluid redistribution regardless of reaction severity, with changes in stroke volume, heart rate, and peripheral blood flow. Administration of intravenous fluids reversed these changes and accelerated symptom resolution.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

Helen Kuehn et al.

Summary: MRGPRX2 is a multiligand receptor highly expressed on skin mast cells, whose agonists may serve as potential biomarkers for the progression of cutaneous inflammatory diseases and response to treatment in patients with inflammatory and pruritic skin diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort

Paola Nicoletti et al.

Summary: This study identified HLA-DRB1*10:01 as a genetic predisposing factor for immediate hypersensitivity reactions to beta-lactam antibiotics, particularly penicillins. Further research is needed to identify other predisposing HLA and non-HLA loci.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Coagulation factors induce human skin mast cell and basophil degranula-tion via activation of complement 5 and the C5a receptor

Yuhki Yanase et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article

Significant association between Taq1 gene polymorphism in vitamin D receptor and chronic spontaneous urticaria in the Northeast of Iran

Maryam Khoshkhui et al.

Clinical and Molecular Allergy (2021)

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Article Dermatology

Interleukin 17 receptor A haplotype analysis in chronic spontaneous urticaria: A preliminary study

Hesham Nada et al.

Summary: The study conducted haplotype analysis for the IL17RA gene in CSU patients, revealing that gene polymorphisms of rs4819554 and rs879577 may be associated with susceptibility to CSU, thereby aiding in predicting the disease progression and severity.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Allergy

US HAEA Medical Advisory Board 2020 Guidelines for the Management of Hereditary Angioedema

Paula J. Busse et al.

Summary: Scientific and clinical progress, along with the development of novel therapeutic options, have led to significant changes in the diagnosis and management of hereditary angioedema (HAE). Updated guidelines based on a comprehensive literature review recommend strategies for classification, diagnosis, treatment, special considerations, management plans, and monitoring to help HAE patients lead a normal life.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Allergy

Canakinumab Lacks Efficacy in Treating Adult Patients with Moderate to Severe Chronic Spontaneous Urticaria in a Phase II Randomized Double-Blind Placebo-Controlled Single-Center Study

Julia-Tatjana Maul et al.

Summary: The study found that canakinumab did not have any effect on lesions of CSU, suggesting that IL-1 beta may not play a crucial role in the pathology of patients with CSU. However, canakinumab was well tolerated with mild adverse events equally distributed between the treatment and placebo groups.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Review Allergy

Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis)

Priya Sellaturay et al.

Summary: This study reports 5 cases of confirmed PEG allergy, with most cases related to medications containing PEGs. Skin tests showed positive reactions in 3 cases, with 2 cases experiencing allergic reactions following the intradermal test.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Allergy

Peanut induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry

Ioana Maris et al.

Summary: The study showed that peanut allergy is a major cause of severe allergic reactions in European children, with characteristics such as asthma comorbidity and a higher rate of biphasic reactions. The use of intramuscular adrenaline as first-line treatment is low and needs improvement. The European Anaphylaxis Registry provides a valuable tool for continuous assessment of anaphylactic reactions.

ALLERGY (2021)

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Article Allergy

The global impact of the COVID-19 pandemic on the management and course of chronic urticaria

Emek Kocaturk et al.

Summary: The COVID-19 pandemic has significantly impacted the care of CU patients, with reduced patient referrals and clinic hours being major reasons. Although CU does not affect the course of COVID-19, the pandemic can exacerbate CU in some patients.

ALLERGY (2021)

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Letter Anesthesiology

Anaphylaxis to the first COVID-19 vaccine: is polyethylene glycol (PEG) the culprit?

Lene H. Garvey et al.

BRITISH JOURNAL OF ANAESTHESIA (2021)

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Article Immunology

miR-126-3p and miR-16-5p as novel serum biomarkers for disease activity and treatment response in symptomatic dermographism

Qi Gao et al.

Summary: The study identified miR-126-3p and miR-16-5p as potential serum biomarkers for symptomatic dermographism (SD) with diagnostic capabilities. The two miRNAs were found to show an inverse correlation with serum level of VEGF-A, indicating their potential role in the pathogenesis of SD.

CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Mutation in KARS: A novel mechanism for severe anaphylaxis

Pau Ribo et al.

Summary: This study investigates a patient with a mutation in the KARS gene, which encodes LysRS, leading to abnormal function in mast cell activation. Through biochemical, functional, and structural analyses, the study provides insights into the molecular mechanisms underlying severe anaphylaxis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Suppression of IgE-mediated anaphylaxis and food allergy with monovalent anti-FcεRIα mAbs

Marat Khodoun et al.

Summary: Monovalent anti-huFc epsilon RI alpha mAbs have advantages in safety over divalent mAbs, with weaker abilities to induce allergic reactions and deplete IgE, but still effectively suppress IgE-mediated diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Severity grading system for acute allergic reactions: A multidisciplinary Delphi study

Timothy E. Dribin et al.

Summary: This study aimed to develop a severity grading system for acute allergic reactions in order to distinguish between different levels of severity, making it intuitive and straightforward for clinical care and research purposes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Consensus on treatment goals in hereditary angioedema: A global Delphi initiative

Marcus Maurer et al.

Summary: Through the Delphi process, experts unanimously agreed that the goals of HAE treatment are achieving total disease control and normalizing the patient's life. The burden of disease and treatment should be considered when assessing disease control and normalization of patients' lives.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach

Aleena Banerji et al.

Summary: The FDA has authorized emergency use of Pfizer-BioNTech and Moderna COVID-19 vaccines, but individuals with severe allergic reactions are advised against receiving them. The CDC recommends observing those with a history of immediate allergies or anaphylaxis for 30 minutes post-vaccination, while all others should be observed for 15 minutes.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

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Article Allergy

Association of PTPN22 single nucleotide polymorphisms with chronic spontaneous urticaria

Maryam Sadr et al.

Summary: The polymorphisms of the PTPN22 gene are associated with an increased susceptibility to CSU in the studied Iranian population, with the rs1310182 T allele being more common in patients.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2021)

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Letter Allergy

Proteomic profile of extracellular vesicles in anaphylaxis and their role in vascular permeability

Emilio Nunez-Borque et al.

ALLERGY (2021)

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Article Biochemistry & Molecular Biology

Fenebrutinib in H-1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial

Martin Metz et al.

Summary: The study investigated the efficacy of Fenebrutinib in treatment of chronic spontaneous urticaria patients, showing dose-dependent improvements in disease activity, especially in patients with refractory type IIb autoimmunity. This supports the potential use of BTK inhibition in antihistamine-refractory CSU.

NATURE MEDICINE (2021)

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Article Allergy

Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab

Donald MacGlashan et al.

Summary: This study examined changes in basophil function and its relationship to auto-antibodies during treatment with omalizumab in patients with chronic spontaneous urticaria (CSU). Results suggest that the presence of auto-antibodies may affect basophil numbers and function in patients treated with omalizumab.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

The efficacy of omalizumab treatment in chronic spontaneous urticaria is associated with basophil phenotypes

Kirti J. Johal et al.

Summary: The study suggests that the baseline basophil count and functional phenotype may predict responsiveness to omalizumab in treating chronic spontaneous urticaria. However, changes in basophil IgE-based histamine release, surface IgE, or Fc epsilon RI do not correlate with the kinetics of improvement in clinical symptoms during therapy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

A randomized double-blind, placebo-controlled study of omalizumab for idiopathic anaphylaxis

Melody C. Carter et al.

Summary: The study aimed to determine the efficacy of omalizumab in managing patients with frequent episodes of IA, showing a trend of efficacy in the treatment group but no statistically significant differences. Overall, omalizumab was safely administered to a difficult-to-treat patient population with IA.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis

Theo Gulen et al.

Summary: This study identified a group of potential biomarkers in plasma that could be used to predict patients with mastocytosis at increased risk of anaphylaxis. In addition to known markers, four novel proteins were discovered, providing important value in screening and identifying patients with this condition.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Letter Dermatology

Association of UBASH3A polymorphism with chronic spontaneous urticaria in a Chinese Han population

Nan Lu et al.

JOURNAL OF COSMETIC DERMATOLOGY (2021)

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Article Allergy

Einsatz von Biologika zur Therapie der Nahrungsmittelallergie

M. Worm et al.

ALLERGOLOGIE (2021)

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Review Allergy

Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria

Yue Zhang et al.

Summary: Urticaria is a skin disease characterized by rapid onset of hives and can be divided into acute and chronic types. Currently, evaluation of chronic urticaria activity relies on the Urticaria Activity Score (UAS), but more reliable experimental data is needed for assessment. This review aims to identify appropriate biomarkers for evaluating disease activity and discovering new therapeutic targets.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2021)

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Article Allergy

Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines

Kimberly A. Risma et al.

Summary: The COVID-19 pandemic has led to the rapid production of messenger RNA vaccines packaged in lipid nanoparticles, resulting in unexpectedly severe allergic reactions. Various factors have been considered as possible contributors to these reactions, including nucleic acid activation of the contact system and preexisting antibody recognition of polyethylene glycol on the nanoparticle surface. Further research and clinical trials are needed to address concerns and determine the applicability of testing methods in predicting and understanding vaccine-related allergic reactions.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Allergy

Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease

Saptarshi Roy et al.

Summary: MRGPRX2, activated by various cationic ligands, plays a role in host defense but overactivation may lead to pseudoallergy and various skin diseases. Gain and loss-of-function missense polymorphisms have been identified in MRGPRX2, and the functionality of certain ligands has been defined. The development of small-molecule HDP mimetics that activate MRGPRX2 presents a new therapeutic approach, while MRGPRX2-specific antibodies and inhibitors could be utilized for modulation of allergic and inflammatory diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Editorial Material Allergy

Omalizumab in non-IgE-mediated diseases

R. Sharon Chinthrajah et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy

Alexander Troelnikov et al.

Summary: Patients with a history of PEG allergy showed positive skin test results after receiving the BNT162b2 vaccine, while traditional PEG skin testing yielded negative results for 2 out of 3 patients. One patient exhibited cross-reactivity to PEG and polysorbate, leading to co-sensitization to both the BNT162b2 and AZD1222 vaccines.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Allergy

A novel histopathological scoring system to distinguish urticarial vasculitis from chronic spontaneous urticaria

Viktoria Puhl et al.

Summary: "The study developed a diagnostic scoring system, the Urticarial Vasculitis Score (UVS), based on histopathologic criteria such as leukocytoclasia, fibrin deposits, and erythrocyte extravasation which distinguishes Urticarial Vasculitis (UV) from Chronic Spontaneous Urticaria (CSU) in skin histopathology."

CLINICAL AND TRANSLATIONAL ALLERGY (2021)

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Article Allergy

Small nucleolar RNA networks are up-regulated during human anaphylaxis

Francesca Marina McGrath et al.

Summary: This study reveals the unique involvement of snoRNAs in the pathogenesis of anaphylaxis, suggesting they could potentially be used as biomarkers of severe anaphylaxis.

CLINICAL AND EXPERIMENTAL ALLERGY (2021)

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Editorial Material Allergy

Treatment of hereditary angioedema: When the goal is having a normal life

Luisa Karla Arruda et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Letter Medicine, General & Internal

Safety Evaluation of the Second Dose of Messenger RNA COVID-19 Vaccines in Patients With Immediate Reactions to the First Dose

Matthew S. Krantz et al.

Summary: This study examines the safety of second doses of messenger RNA COVID-19 vaccines following allergic reactions to the first dose.

JAMA INTERNAL MEDICINE (2021)

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Article Allergy

Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects

Nobuyuki Nishimori et al.

Summary: The serum level of hemokinin-1 (HK-1) was significantly lower in patients with severe chronic spontaneous urticaria (CSU), and high concentrations of HK-1 in nonatopic healthy subjects may prevent Mas-related G protein-coupled receptor X2 (MRGPRX2)-mediated mast cell activation in preventing MC degranulation by substance P (SP).

ALLERGOLOGY INTERNATIONAL (2021)

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Article Medicine, General & Internal

Assessment of Allergic and Anaphylactic Reactions to mRNA COVID-19 Vaccines With Confirmatory Testing in a US Regional Health System

Christopher Michael Warren et al.

Summary: This study analyzed 22 patients with suspected allergic reactions to mRNA COVID-19 vaccines, indicating a potential non-IgE mediated immune response to PEG in most individuals. Women and those with a history of allergic reactions may have an elevated risk of mRNA vaccine allergy.

JAMA NETWORK OPEN (2021)

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Article Genetics & Heredity

Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria

Juan Li et al.

PHARMACOGENOMICS JOURNAL (2020)

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Editorial Material Allergy

Autoinflammatory disease: New mouse models and therapies

Hal M. Hoffman

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Immunology

Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation

Thomas Plum et al.

IMMUNITY (2020)

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Article Allergy

NLRP3-associated autoinflammatory diseases: Phenotypic and molecular characteristics of germline versus somatic mutations

Camille Louvrier et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Management of urticarial vasculitis: A worldwide physician perspective

Pavel Kolkhir et al.

WORLD ALLERGY ORGANIZATION JOURNAL (2020)

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Article Allergy

Contact urticaria and protein contact dermatitis in the Finnish Register of Occupational Diseases in a period of 12 years

Maria Pesonen et al.

CONTACT DERMATITIS (2020)

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Article Allergy

RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis

Gordon S. Wong et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyperresponsiveness

Shruti Rastogi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

The role of eosinophils in chronic spontaneous urticaria

Sabine Altrichter et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Dermatology

Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2

Andrea N. Naranjo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Letter Allergy

Peanut oral immunotherapy protects patients from accidental allergic reactions to peanut

Valerie Trendelenburg et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Multidisciplinary Sciences

Sialylation of immunoglobulin E is a determinant of allergic pathogenicity

Kai-Ting C. Shade et al.

NATURE (2020)

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Review Allergy

Urticaria and the gut

Chia-Yu Chu et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Risk Factors and Characteristics of Biphasic Anaphylaxis

Magdalena Kraft et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2020)

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Article Biochemistry & Molecular Biology

Interleukin 1Gene Polymorphisms Presumably Participate in the Pathogenesis of Chronic Spontaneous Autoreactive Urticaria

Zenon Brzoza et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2020)

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Review Allergy

Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

Peter A. Nigrovic et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Medicine, General & Internal

The association between chronic spontaneous urticaria and HLA class I and class II antigen

Neslihan Dogan et al.

TURKISH JOURNAL OF MEDICAL SCIENCES (2020)

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Article Allergy

Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: A randomized, double-blind, placebo-controlled study

Martin Metz et al.

ALLERGY (2019)

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Article Allergy

Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils

Donald MacGlashan

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Allergy

Treatment of urticarial vasculitis: A systematic review

Pavel Kolkhir et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Allergy

Treatments of cold urticaria: A systematic review

Kanokvalai Kulthanan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

IL-6 and IL-1β expression is increased in autologous serum skin test of patients with chronic spontaneous urticaria

Laurence de Montjoye et al.

ALLERGY (2019)

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Letter Allergy

Increased expression of IL-24 in chronic spontaneous urticaria

Laurence de Montjoye et al.

ALLERGY (2019)

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Article Immunology

Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion

Juan-Manuel Leyva-Castillo et al.

IMMUNITY (2019)

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Review Immunology

CAPS and NLRP3

Laela M. Booshehri et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2019)

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Article Hematology

Frequency and prognostic impact of KIT and other genetic variants in indolent systemic mastocytosis

Javier I. Munoz-Gonzalez et al.

BLOOD (2019)

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Article Allergy

Contact urticaria: Frequency, elicitors and cofactors in three cohorts (Information Network of Departments of Dermatology; Network of Anaphylaxis; and Department of Dermatology, University Hospital Erlangen, Germany)

Helene Suess et al.

CONTACT DERMATITIS (2019)

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Article Allergy

Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions

Marcus Maurer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Cell Biology

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

Friederike Jonsson et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Neurosciences

Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function

Gilda Varricchi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Review Gastroenterology & Hepatology

Systematic review and meta-analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria

Hyun Jung Kim et al.

HELICOBACTER (2019)

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Letter Allergy

Basophil histamine release in patients with chronic spontaneous urticaria: Optimize or minimize

Allen P. Kaplan

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Allergy

Advances in drug allergy, urticaria, angioedema, and anaphylaxis in 2018

Rachel L. Miller et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Altered Gut Microbiota Diversity and Composition in Chronic Urticaria

Tao Lu et al.

DISEASE MARKERS (2019)

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Article Medicine, General & Internal

Ligelizumab for Chronic Spontaneous Urticaria

Marcus Maurer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Allergy

Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation

Zuotao Zhao et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Dermatology

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