Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 71, Issue 3, Pages 1369-1380Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c06422
Keywords
ferulic acid; cyclized derivatives; antiviral activities; pepper mild mottle virus; photosynthesis
Ask authors/readers for more resources
In order to develop new antiviral agents, novel cyclized derivatives of ferulic acid were designed and synthesized. These derivatives showed desirable antiviral activities against CMV, PMMoV, and TSWV. Compound 5e exhibited excellent protective activities against the three viruses, with EC50 values superior to those of trans-ferulic acid, dufulin, and ningnanmycin. The protective mechanisms of 5e were found to involve regulating photosynthesis in the host.
To further develop new antiviral agents, several novel cyclized derivatives of ferulic acid were designed and synthesized. Their antiviral activities were evaluated against the cucumber mosaic virus (CMV), pepper mild mottle virus (PMMoV), and tomato spotted wilt virus (TSWV). The results showed that some ferulic acid derivatives exhibited desirable antiviral activities. Particularly, compound 5e exhibited excellent protective activities against CMV, PMMoV, and TSWV, with EC50 values of 167.2, 102.5, and 145.8 mu g mL-1, respectively, which were superior to those obtained for trans-ferulic acid (581.7, 611.2, and 615.4 mu g mL-1), dufulin (312.6, 302.5, and 298.2 mu g mL-1), and ningnanmycin (264.3, 282.5, and 276.5 mu g mL-1). Thereafter, the protective mechanisms of 5e were evaluated through photosynthesis evaluation, transcriptome profiling, and proteomic analysis. The results indicated that 5e significantly activated the expression levels of photosynthesis-related regulatory genes and proteins in tobacco plants and promoted the accumulation of defense molecules to resist viral infection. Thus, the findings of this study indicated that novel cyclized ferulic acid derivatives are potential antiviral agents that act via regulating photosynthesis in the host.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available