4.7 Article

2-Hydroxychalcone as a Novel Natural Photosynthesis Inhibitor against Bloom-Forming Cyanobacteria

Journal

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 70, Issue 48, Pages 15069-15079

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c06665

Keywords

cyanobacterial bloom; Microcystis aeruginosa; 2-hydroxychalcone; algicide; photosynthesis inhibitor

Funding

  1. National Natural Science Foundation of China
  2. Fundamental Research Funds for the Central Universities
  3. Key R&D and Transformation Plan of Qinghai Province
  4. [31901181]
  5. [YZZ20003]
  6. [CZY20042]
  7. [2021-QY-210]

Ask authors/readers for more resources

This study discovered that 2-hydroxychalcone efficiently inhibited the growth of bloom-forming Microcystis aeruginosa by selectively interfering with photosynthesis. It has the potential to be an ecofriendly algicide with strong specificity.
The control of harmful cyanobacterial blooms has been becoming a global challenge. The development of ecofriendly algicides with strong specificity is urgently needed. The photosynthetic apparatus is a promising target site for algicides to minimize the possible harmful effects on animals and humans. In this study, biologically derived 2-hydroxychalcone efficiently inhibited the growth of bloom-forming M. aeruginosa by selectively interfering with photosynthesis. 2-Hydroxychalcone targeting Photosystem II (PSII) inhibited electron transfer between the primary and secondary electron acceptors (QA and QB) and the binding of plastoquinone (PQ) molecules to the QB binding pocket at the acceptor side of PSII, as revealed by polyphasic chlorophyll (Chl) a fluorescence induction and QA- reoxidation kinetics. Molecular docking for 2-hydroxychalcone to D1 protein and the proteomic responses of M. aeruginosa suggested that 2-hydroxychalcone formed a stable monodentate ligand with the nonheme iron in D1 protein, provoking significant modulation of PSII proteins. The unique binding mode of 2-hydroxychalcone with PSII differentiated it from classical PSII inhibitors. Furthermore, 2-hydroxychalcone down-regulated the expression of microcystin (MC) synthesis-related genes to restrain MC synthesis and release. These results indicated the potential application of 2-hydroxychalcone as an algicide or a template scaffold for designing novel derivatives with superior algicidal activity.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available