4.7 Article

Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage

Related references

Note: Only part of the references are listed.
Article Rheumatology

Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis

Rebecca A. Symons et al.

Summary: The IL-6-Yap-Snail signaling axis plays a critical role in the pathogenic transformation of synovial fibroblasts in inflammatory arthritis, where Yap activation is regulated by IL-6 and SF invasiveness is influenced by Yap.

ANNALS OF THE RHEUMATIC DISEASES (2022)

Review Biochemistry & Molecular Biology

The effects of post-translational modifications on Th17/Treg cell differentiation

Gwenaelle Le Menn et al.

Summary: Regulatory T (Treg) cells and Th17 cells play essential roles in immune homeostasis and infection. Dysregulation of the Th17/Treg cell balance contributes to the development of various diseases. Multiple factors influence the balance, including signaling, cytokines, metabolism, and epigenetic regulators.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2022)

Review Immunology

Epigenetics and CD8+ T cell memory*

Gaia Montacchiesi et al.

Summary: After antigen recognition, CD8(+) T lymphocytes differentiate into different subsets with distinct phenotypes, functions, and migration properties. Transcription factors and chromatin structure changes drive the functional differentiation and phenotypic diversity of these T cell subsets, which has implications for new immunotherapy protocols and vaccination strategies. Understanding the contribution of chromatin architecture and transcription factor activity in guiding CD8(+) T cell subset commitment is important for T cell plasticity, stability, and memory in infection and cancer.

IMMUNOLOGICAL REVIEWS (2022)

Article Food Science & Technology

Bifidobacterium animalis subsp. lactis lkm512 Attenuates Obesity-Associated Inflammation and Insulin Resistance Through the Modification of Gut Microbiota in High-Fat Diet-Induced Obese Mice

Lingyan Ma et al.

Summary: The longevity-promoting probiotic strain LKM512 shows potential in improving hepatic lipid accumulation, reducing inflammation, and enhancing insulin sensitivity in high-fat diet-induced obese mice. It also has an impact on the composition and function of gut microbiota in these mice.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Article Biochemistry & Molecular Biology

Immune competence and spleen size scale with colony status in the naked mole-rat

Valerie Begay et al.

Summary: The spleen of naked mole-rats differs from that of other rodents in terms of anatomy, molecular composition, and function. Healthy naked mole-rats show variation in spleen size, with enlarged spleens associated with better immune profiles and higher social rank within the colony.

OPEN BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights

Bowen Li et al.

Summary: This article summarizes the research progress on the influence of gut microbiota on systemic inflammatory arthritis and the development of microbiota-assisted therapy. The limitations of current treatments are analyzed, and the research progress of microbiota regulation in systemic inflammatory arthritis is summarized. The partial mechanisms of microbiota-assisted therapy are discussed. The article also points out the future direction of microbiota-assisted therapy.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Gastroenterology & Hepatology

Leveraging diet to engineer the gut microbiome

Mathis Wolter et al.

Summary: Autoimmune diseases share patterns of gut microbiome perturbation and immune dysregulation linked to intestinal barrier dysfunction. Dietary tools for precise engineering of the gut microbiome have the potential to modulate host-microbiome interaction in the treatment of autoimmune diseases.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Rheumatology

The gut-joint axis in rheumatoid arthritis

Mario M. Zaiss et al.

Summary: The review discusses the role of intestinal dysbiosis in rheumatoid arthritis and highlights the potential pathogenic role of gut-derived immune cells in the joints. It also explores the hypothesis that alterations in the microbial flora may precede the onset of RA and suggests that modulation of intestinal microbiota could be a potential therapeutic approach for preventing or treating RA.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Immunology

Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Regulation and Gut Microbiota Modulation: A Double-Blind, Randomized, Placebo-Controlled Study

Bo Yang et al.

Summary: Irritable bowel syndrome with diarrhea and functional diarrhea are two functional bowel disorders that lead to chronic diarrhea, and probiotics have shown potential in alleviating this condition.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies

Ramy S. Gabarin et al.

Summary: Sepsis is characterized by organ dysfunction due to a dysregulated systemic host response to infection. Lipopolysaccharide (LPS) is a major mediator in sepsis, triggering inflammation through various pathways. Inhibiting intracellular LPS signaling by targeting caspases-4/5/1 or downstream effectors may be a promising therapeutic approach for sepsis treatment.

JOURNAL OF INNATE IMMUNITY (2021)

Review Rheumatology

Intestinal permeability in spondyloarthritis and rheumatoid arthritis: A systematic review of the literature

Sophie Hecquet et al.

Summary: Intestinal permeability is increased in patients with spondyloarthritis, while its impact on rheumatoid arthritis patients is more controversial. NSAID treatment does not seem to affect intestinal permeability in spondyloarthritis patients, but it appears to increase permeability in rheumatoid arthritis patients.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2021)

Article Immunology

Lactobacillus casei CCFM1074 Alleviates Collagen-Induced Arthritis in Rats via Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota

Zhexin Fan et al.

Summary: This study investigated the effects of two L. casei strains on collagen-induced arthritis in rats and found that CCFM1074 alleviated arthritis through rebalancing gut microbiota, immune responses, and plasma metabolites. The study also revealed that CCFM1074 possessed more functional genes involved in carbohydrate metabolism and regulated the gut microbiota by modulating community structure and abundance of specific bacteria. Differential metabolites modulated by CCFM1074 included eicosapentaenoic acid and docosapentaenoic acid, which are involved in unsaturated fatty acids metabolism.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Prevotella histicola Protects From Arthritis by Expansion of Allobaculum and Augmenting Butyrate Production in Humanized Mice

Baskar Balakrishnan et al.

Summary: The study showed that P. histicola MCI 001 can be used to treat autoimmune diseases by improving gut microbial structure and metabolites to restore immunity and gut homeostasis.

FRONTIERS IN IMMUNOLOGY (2021)

Article Microbiology

Probiotics Modulate Mouse Gut Microbiota and Influence Intestinal Immune and Serotonergic Gene Expression in a Site-Specific Fashion

Valentina Taverniti et al.

Summary: This study compared the effects of three different probiotic bacterial strains on three distinct murine intestinal sites, showing that probiotics can modulate the intestinal microbiota and affect host gene expression in a strain-specific manner. The study provides a rationale for investigating the effects of probiotics on the serotonergic system.

FRONTIERS IN MICROBIOLOGY (2021)

Review Physiology

Use of Short-Chain Fatty Acids for the Recovery of the Intestinal Epithelial Barrier Affected by Bacterial Toxins

Diliana Perez-Reytor et al.

Summary: Short-chain fatty acids (SCFAs) produced by gut microbial anaerobic fermentation can activate signaling cascades and increase intestinal barrier integrity. They inhibit the virulence of enteric pathogens and have protective effects against bacterial colonization.

FRONTIERS IN PHYSIOLOGY (2021)

Review Immunology

Role of Intestinal Microbiota on Gut Homeostasis and Rheumatoid Arthritis

Mingxin Li et al.

Summary: Rheumatoid arthritis is a chronic inflammatory disease immune mediated. Gut microbiota dysbiosis may contribute to the development of RA, with proximal intestinal immunomodulatory cells potentially playing a key role in influencing the pathogenesis of the disease.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

Article Immunology

The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response

Zhiwen Gu et al.

Summary: TRIM60 negatively regulates TAK1 signalosome formation and activation by SUMOylating TAB2, inhibiting downstream MAPK and NF-kappa B pathways. Deficiency of TRIM60 in macrophages leads to elevated proinflammatory cytokine levels and enhanced immune response.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis

Narges Tajik et al.

NATURE COMMUNICATIONS (2020)

Article Gastroenterology & Hepatology

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

Paola Paone et al.

Review Cell Biology

Tight Junction Structure and Function Revisited

Tetsuhisa Otani et al.

TRENDS IN CELL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression

Yang Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Immunology

Prebiotics can change immunomodulatory properties of probiotics

Pavlina Sredkova et al.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2020)

Article Gastroenterology & Hepatology

Faecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier

Sarit Hoffman et al.

JOURNAL OF CROHNS & COLITIS (2019)

Article Agriculture, Multidisciplinary

Spatial Learning and Memory Impairment in Growing Mice Induced by Major Oxidized Tyrosine Product Dityrosine

Bowen Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Review Food Science & Technology

A next generation probiotic, Akkermansia muciniphila

Qixiao Zhai et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Review Pharmacology & Pharmacy

A slippery slope: On the origin, role and physiology of mucus

Farhan Taherali et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Medicine, General & Internal

The Plasticity of Th17 Cells in the Pathogenesis of Rheumatoid Arthritis

Shigeru Kotake et al.

JOURNAL OF CLINICAL MEDICINE (2017)

Article Genetics & Heredity

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

Jun Chen et al.

GENOME MEDICINE (2016)

Article Biochemistry & Molecular Biology

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

Xuan Zhang et al.

NATURE MEDICINE (2015)

Meeting Abstract Biotechnology & Applied Microbiology

Is there an impact of Claudin-5 for reflecting disease activity in rheumatoid arthritis?

Gonul Gurol et al.

JOURNAL OF BIOTECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

Nanda Burger-van Paassen et al.

BIOCHEMICAL JOURNAL (2009)

Review Allergy

Intestinal barrier function: Molecular regulation and disease pathogenesis

Katherine R. Groschwitz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

Article Biochemical Research Methods

Collagen-induced arthritis

David D. Brand et al.

NATURE PROTOCOLS (2007)