4.7 Article

Bifidobacterium breve CCFM1078 Alleviates Collagen-Induced Arthritis in Rats via Modulating the Gut Microbiota and Repairing the Intestinal Barrier Damage

Journal

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 70, Issue 46, Pages 14665-14678

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.2c04602

Keywords

Bifidobacterium breve; gut microbiota; intestinal barrier; inflammatory; arthritis

Funding

  1. National Natural Science Foundation of China
  2. Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
  3. [32021005]
  4. [31820103010]

Ask authors/readers for more resources

This study found that Bifidobacterium breve CCFM1078 can alleviate joint inflammation by adjusting the profile of gut microbiota and enhancing the intestinal barrier, as well as reducing the release of inflammatory cytokines.
This study focused on the effects of Bifidobacterium breve CCFM1078 on the intestinal barrier and systemic inflammation of collagen-induced arthritis (CIA) rats. Female rats were divided into three groups with daily intragastric administration of either saline (control group and model group) or B. breve CCFM1078 (CCFM1078 group, 3 x 109cfu/rat per day) for 5 weeks. In the Model and CCFM1078 groups, arthritis was induced by subcutaneous collagen injection. We found that B. breve CCFM1078 can repair the intestinal barrier, reduce LPS translocation, regulate gut microbiota composition, and increase short-chain fatty acids in the intestine. Then, it can reduce pro-inflammatory cytokines release, adjust immune dysfunction, and inhibit TLR4MyD88-dependent pathways and downstream inflammatory pathways to alleviate joint inflammation in CIA rats. These findings suggest that B. breve CCFM1078 may alleviate joint inflammation by adjusting the profile of gut microbiota and enhancing the intestinal barrier.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available