Involvement of sialoglycans in SARS-COV-2 infection: Opportunities and challenges for glyco-based inhibitors

Article Chemistry, Multidisciplinary

The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View

Luca Unione et al.

Summary: The interaction between the SARS CoV2 spike glycoprotein and two sialic acid-containing trisaccharides has been demonstrated, with the sialic acid binding site located at the N-terminal domain.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA

Eike Siebs et al.

Summary: This study reports a new approach to inhibit the formation of Pseudomonas aeruginosa biofilms. By synthesizing galactosidic LecA inhibitors with aromatic moieties targeting the central pocket, the formation of biofilms was successfully reduced.

CHEMBIOCHEM (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2

Linh Nguyen et al.

Summary: Evidence suggests that host glycans, specifically glycolipids containing sialic acid, play a role in facilitating the entry of SARS-CoV-2 virus into host cells by binding to the receptor-binding domain (RBD) of the spike protein. Depletion of cell surface sialic acid levels through various methods decreases RBD binding and infection of the virus, indicating the importance of sialylated glycans in viral entry.

NATURE CHEMICAL BIOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S

Aoife M. Harbison et al.

Summary: The dense glycan shield of the SARS-CoV-2 spike plays a crucial role in immune evasion and activating the prefusion conformation. Recent studies have shown that the structures and occupancy of SARS-CoV-2 S glycans depend on both the host cell and the stability of the trimer. The type of glycosylation at specific sites greatly affects the stability of the receptor binding domain conformation, and the loss of glycosylation at another site may have contributed to increased infectivity.

CHEMICAL SCIENCE (2022)

Add to Collection

Article Cell Biology

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

Wenwe Li et al.

Summary: This study elucidates the structural basis and mode of action for two potent SARS-CoV-2 spike-neutralizing monoclonal antibodies. CV3-1 triggers shedding of the S1 subunit by binding to a loop structure in the receptor-binding domain (RBD), while CV3-25 inhibits membrane fusion by binding to an epitope in the stem helix region of the S2 subunit. Designing vaccine immunogens that incorporate conserved regions in the RBD and stem helix region could elicit pan-coronavirus protective immune responses.

CELL REPORTS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Principles of SARS-CoV-2 glycosylation

Himanshi Chawla et al.

Summary: Research has shown that the structure and post-translational processing of the SARS-CoV-2 spike glycoprotein are closely associated with the function of the virus and the efficacy of sterilizing vaccines. The study suggests that glycans play an important role in the immunogen structure and efficacy.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Glycans and Glycosylation in SARS-COV2 Infection session at the XVII Advanced School in Carbohydrate Chemistry, Italian Chemical Society. July 4th-7th 2021, Pontignano (Si), Italy Abstracts

Domenico Garozzo et al.

GLYCOCONJUGATE JOURNAL (2022)

Add to Collection

Article Multidisciplinary Sciences

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

Simon J. L. Petitjean et al.

Summary: This study reveals that SARS-CoV-2 specifically binds to 9-O-acetylated sialic acid on cell surfaces and proposes novel inhibitors for viral infection. Understanding the molecular details of virus-cell binding and developing anti-viral strategies are urgent tasks in response to the emergence of highly transmissible SARS-CoV-2 variants.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction

Scott E. Guimond et al.

Summary: This study found that the synthetic HS mimetic pixatimod can interact with the receptor binding domain of the SARS-CoV-2 spike protein and directly inhibit its binding to ACE2. The results show that pixatimod can effectively inhibit the infection of multiple clinical isolates of SARS-CoV-2 virus and has broad potency against various variants. In a mouse model, pixatimod also reduces viral titers and weight loss. This study provides strong evidence for the potential use of synthetic HS mimetics as a therapeutic approach for COVID-19.

ACS CENTRAL SCIENCE (2022)

Add to Collection

Review Cell Biology

SARS-CoV-2 Attacks in the Brain: Focus on the Sialome

Przemyslaw Wielgat et al.

Summary: This paper discusses the important role of brain sialome in the neuropathology of COVID-19 and SARS-CoV-2.

CELLS (2022)

Add to Collection

Article Virology

The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint

Hua Guo et al.

Summary: The N-terminal domains of sarbecoviruses are highly diverse, and their function is not well studied compared to the receptor-binding domains. This study demonstrates that the N-terminal domains of sarbecovirus can be divided into five clades and show varying levels of glycan binding. The researchers also found that sarbecoviruses interact with cell surface glycans and that the presence of sialic acids on human lung cells inhibits sarbecovirus infection, which is different from other respiratory coronaviruses.

JOURNAL OF VIROLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Pathogen-sugar interactions revealed by universal saturation transfer analysis

Charles J. Buchanan et al.

Summary: This study utilizes universal saturation transfer analysis to reveal the interaction between the novel coronavirus and glycan compounds, and identifies protein mutations related to pathogenicity and zoonosis.

SCIENCE (2022)

Add to Collection

Review Pharmacology & Pharmacy

Engineering ACE2 decoy receptors to combat viral escapability

Takao Arimori et al.

Summary: This review summarizes recent developments in preclinical studies utilizing recombinant ACE2 decoy receptors against coronaviruses, highlighting the potential therapeutic efficacy achieved through various high-affinity mutagenesis and Fc fusion approaches. The relevance of stimulating effector immune cells and using liquid aerosol delivery for defense against ACE2-utilizing coronaviruses is also emphasized.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Add to Collection

Article Microbiology

Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2

Wakana Saso et al.

Summary: This study identified that alpha 2-6-linked sialic acid-containing compounds play a significant role in the efficient spread of SARS-CoV-2 infection, while this was not the case with SARS-CoV. The binding of alpha 2-6-linked compounds to the SARS-CoV-2 spike S1 subunit competitively inhibits the attachment of SARS-CoV-2 to host cells. Removal of cell surface sialic acids impairs the interaction between the SARS-CoV-2 spike and angiotensin-converting enzyme 2 (ACE2), leading to the suppression of SARS-CoV-2 infection. This study provides a molecular basis for understanding the distinct characteristics of SARS-CoV-2 compared to SARS-CoV.

PLOS PATHOGENS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Exploring the Potential of Chemical Inhibitors for Targeting Post-translational Glycosylation of Coronavirus (SARS-CoV-2)

Nancy Tripathi et al.

Summary: The glycosylation pathway of the SARS-CoV-2 virus and target cells crucially affect the infection, and inhibition of N-glycan biosynthesis could block viral entry. Chemical inhibitors of viral glycosylation could be potential therapeutic targets for Covid-19.

ACS OMEGA (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Spike-heparan sulfate interactions in SARS-CoV-2 infection

Fiona L. Kearns et al.

Summary: Heparan sulfate, a major component of the cellular glycocalyx, plays a crucial role in the infection cycle of SARS-CoV-2. It facilitates the open conformation of the spike protein, enabling its binding to ACE2. The coordination between viral and host glycans on the spike protein is essential for the binding and subsequent infection.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)

Add to Collection

Article Immunology

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Weiqi Hong et al.

Summary: Neutrophil extracellular traps (NETs) release histones that enhance the infectivity of SARS-CoV-2 and promote cell-cell fusion. The study suggests that SARS-CoV-2 can hijack histones from NETosis to facilitate its attachment and entry into host cells.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins

Sakonwan Kuhaudomlarp et al.

Summary: Due to the antimicrobial resistance crisis, lectins are considered novel drug targets, with the study focusing on non-carbohydrate inhibitors for LecA. A catechol was identified as an experimentally confirmed hit, acting as a millimolar LecA inhibitor. The first co-crystal structure of a non-carbohydrate inhibitor in complex with a bacterial lectin demonstrated how the catechol mimics the binding of natural glycosides with LecA, indicating a fundamentally new class of glycomimetics.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Article Microbiology

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Allison J. Greaney et al.

Summary: Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are key in neutralizing antibody responses, and a deep mutational scanning method was used to assess the impact of all amino-acid mutations in the RBD on antibody binding with 10 human monoclonal antibodies. The study identified the clustered escape mutations in different surfaces of the RBD that correspond to structurally defined antibody epitopes, showing that even antibodies targeting the same surface can have distinct escape mutations.

CELL HOST & MICROBE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation

Maaran Michael Rajah et al.

Summary: Severe cases of COVID-19 are associated with lung abnormalities, notably the presence of syncytial pneumocytes. New variants of the virus, such as Alpha and Beta, have shown an increased ability to form larger and more numerous syncytia compared to the ancestral strain D614G. The spike proteins of these variants also display higher affinity for the ACE2 receptor and can be inhibited by interferon-induced transmembrane proteins. Individual mutations in the spike proteins affect fusogenicity, ACE2 binding, and recognition by monoclonal antibodies. Additionally, the Delta variant spike protein has been found to trigger faster fusion than the D614G strain, indicating an enhanced syncytia formation capability in emerging SARS-CoV-2 variants.

EMBO JOURNAL (2021)

Add to Collection

Article Multidisciplinary Sciences

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Bryan A. Johnson et al.

Summary: The genetic mutation in SARS-CoV-2 resulted in better fitness in some cells but lower replication capacity in human respiratory cell lines. Despite reducing disease symptoms, the Delta PRRA mutant provided protection against rechallenge with the wildtype SARS-CoV-2.

NATURE (2021)

Add to Collection

Article Multidisciplinary Sciences

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

Tyler N. Starr et al.

Summary: Research has found that mutations in the receptor binding domain (RBD) of SARS-CoV-2 may potentially escape the action of the REGN-COV2 cocktail, providing important information for interpreting mutations observed during viral surveillance.

SCIENCE (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2

Jonathan Cramer et al.

Summary: DC-SIGN is a pattern recognition receptor implicated in virus dissemination and innate immune response stimulation, making it a potential target for host-directed strategies to attenuate the progression of viral infections. The discovery of potent glycomimetic ligands with improved binding affinity provides promising prospects for the development of targeted therapeutics against a broad spectrum of viral infections.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Cell entry by SARS-CoV-2

Ruchao Peng et al.

Summary: SARS-CoV-2 enters host cells by interacting with the ACE2 receptor, leading to fusion between viral and cellular membranes, with involvement of auxiliary receptors and cofactors. Understanding the molecular events during viral entry is crucial for developing vaccines and therapeutics.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum et al.

Summary: The study identifies 41 human monoclonal antibodies that recognize the N-terminal domain of the SARS-CoV-2 spike protein and exhibit strong neutralizing activity. These antibodies inhibit cell-to-cell fusion, activate effector functions, and protect animals from virus challenge, highlighting the importance of NTD-specific neutralizing antibodies for protective immunity and vaccine development. Several SARS-CoV-2 variants with mutations in the NTD supersite suggest ongoing selective pressure on the virus.

CELL (2021)

Add to Collection

Article Immunology

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Qiao Lu et al.

Summary: Multiple C-type lectins and TTYH2 were identified as glycan-dependent binding partners of SARS-CoV-2 spike, predominantly expressed on myeloid cells in the lungs of COVID-19 patients. Engagement of these receptors with the virus induced robust proinflammatory responses, correlating with disease severity. Targeting SARS-CoV-2-myeloid receptor interactions may provide potential therapeutic strategies for COVID-19.

IMMUNITY (2021)

Add to Collection

Article Medicine, General & Internal

Targeting conserved N-glycosylation blocks SARS-CoV-2 variant infection in vitro

Hsiang-Chi Huang et al.

Summary: By targeting the glycosylation of viral spike protein, particularly through inhibiting STT3A, there is a potential to reduce infectivity of SARS-CoV-2 and its variants, enhancing the neutralizing abilities of antibodies, vaccines, or convalescent sera and reducing the spread of SARS-CoV-2 variants. An ADC coupling non-neutralization anti-spike antibody with NGI-1 shows promising efficacy in targeting SARS-CoV-2-infected cells.

EBIOMEDICINE (2021)

Add to Collection

Letter Cell Biology

Identification of oligosaccharyltransferase as a host target for inhibition of SARS-CoV-2 and its variants

Yi-Jiao Huang et al.

CELL DISCOVERY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19

Corleone S. Delaveris et al.

Summary: Severe cases of COVID-19 are characterized by a hyperinflammatory immune response, with the formation of proinflammatory neutrophil extracellular traps (NETs) playing a key role in inducing inflammation cascade. Activating the neutrophil checkpoint receptor Siglec-9 can suppress NETosis induced by COVID-19 severity-related factors, presenting a promising therapeutic strategy.

ACS CENTRAL SCIENCE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

David Hoffmann et al.

Summary: The study found that Clec4g and CD209c lectins can bind to the Spike protein of SARS-CoV-2, interfering with the virus' attachment to cell surfaces and significantly reducing infections. This provides hope for pan-variant therapeutic interventions.

EMBO JOURNAL (2021)

Add to Collection

Article Multidisciplinary Sciences

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

Florian A. Lempp et al.

Summary: The study reveals that C-type lectin receptors and other factors can serve as attachment receptors for SARS-CoV-2 infection, enhancing ACE2-mediated infection and modulating the neutralizing activity of antibodies.

NATURE (2021)

Add to Collection

Article Microbiology

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

Michel Thepaut et al.

Summary: The study reveals that C-type lectin receptors (CLRS) can bind to the spike envelope protein of SARS-CoV-2, and DC-SIGN and L-SIGN among them can promote virus trans-infection. This discovery identifies a new mechanism for enhancing viral spread.

PLOS PATHOGENS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2

Razie Amraei et al.

Summary: The study identified CD209L and CD209 as receptors for SARS-CoV-2 entry into human cells. CD209L is prominently expressed in lung and kidney tissues and interacts with ACE2, potentially playing a role in SARS-CoV-2 infection. This finding may have implications for antiviral drug development in tissues where ACE2 expression is low or absent.

ACS CENTRAL SCIENCE (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein

Bingqian Li et al.

Summary: COVID-19, caused by SARS-CoV-2, is a global pandemic with infection achieved through binding of spike protein with ACE2. Recent studies show potential multiple receptors for SARS-CoV-2 and similarity with MERS-CoV.

FRONTIERS IN CHEMISTRY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication

Elizabeth C. Clarke et al.

Summary: The study investigated two iminosugars, celgosivir and UV-4, which were effective at inhibiting authentic SARS-CoV-2 viral replication in a cell culture system. These findings suggest that iminosugars should be urgently investigated as potential SARS-CoV-2 inhibitors.

GLYCOBIOLOGY (2021)

Add to Collection

Article Engineering, Biomedical

Exploring the Association Between Sialic Acid and SARS-CoV-2 Spike Protein Through a Molecular Dynamics-Based Approach

Leonardo Bo et al.

Summary: Recent experimental evidence shows that the SARS-CoV-2 Spike protein can bind to sialic acid molecules, shedding light on the virus's molecular mechanism for cell invasion. Through molecular dynamics simulations, researchers identified various possible binding conformations between the N-terminal domain of the spike protein and a sialic acid molecule.

FRONTIERS IN MEDICAL TECHNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Add to Collection

Article Microbiology

Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection

Enya Qing et al.

MBIO (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

Add to Collection

Article Multidisciplinary Sciences

Site-specific glycan analysis of the SARS-CoV-2 spike

Yasunori Watanabe et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen et al.

CELL (2020)

Add to Collection

Article Microbiology

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

Peng Zhao et al.

CELL HOST & MICROBE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

Antoni G. Wrobel et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition

Oliver C. Grant et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

Lorenzo Casalino et al.

ACS CENTRAL SCIENCE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device

Alexander N. Baker et al.

ACS CENTRAL SCIENCE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2

Asif Shajahan et al.

GLYCOBIOLOGY (2020)

Add to Collection

Article Cell Biology

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

Qi Zhang et al.

CELL DISCOVERY (2020)

Add to Collection

Article Biology

Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

Qi Yang et al.

ELIFE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps fromd-galactose pentaacetate

Eva Zahorska et al.

CHEMICAL COMMUNICATIONS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Exploitation of glycosylation in enveloped virus pathobiology

Yasunori Watanabe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Structural basis for human coronavirus attachment to sialic acid receptors

M. Alejandra Tortorici et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

Young-Jun Park et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Add to Collection

Review Chemistry, Organic

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

Matthew B. Calvert et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2018)

Add to Collection

Article Cell Biology

Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding

Miao Gui et al.

CELL RESEARCH (2017)

Add to Collection

Article Multidisciplinary Sciences

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

Wentao Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Article Multidisciplinary Sciences

Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains

Yuan Yuan et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Effects of Sialic Acid Modifications on Virus Binding and Infection

Brian R. Wasik et al.

TRENDS IN MICROBIOLOGY (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Stefania Ordanini et al.

CHEMICAL COMMUNICATIONS (2015)

Add to Collection

Review Microbiology

The sweet spot: defining virus-sialic acid interactions

Jennifer E. Stencel-Baerenwald et al.

NATURE REVIEWS MICROBIOLOGY (2014)

Add to Collection

Article Multidisciplinary Sciences

A lipid zipper triggers bacterial invasion

Thorsten Eierhoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection

Article Chemistry, Multidisciplinary

In Silico-Aided Design of a Glycan Ligand of Sialoadhesin for in Vivo Targeting of Macrophages

Corwin M. Nycholat et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Add to Collection

Article Virology

Structural Basis of Rotavirus Strain Preference toward N-Acetyl- or N-Glycolylneuraminic Acid-Containing Receptors

Xing Yu et al.

JOURNAL OF VIROLOGY (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles

Thomas Haselhorst et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Add to Collection

Article Biochemistry & Molecular Biology

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

Emma C. Nilsson et al.

NATURE MEDICINE (2011)

Add to Collection

Article Multidisciplinary Sciences

Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957

Junfeng Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Add to Collection

Review Biochemistry & Molecular Biology

Sialic acids in human health and disease

Ajit Varki

TRENDS IN MOLECULAR MEDICINE (2008)

Add to Collection

Article Microbiology

The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa

Stephen P. Diggle et al.

ENVIRONMENTAL MICROBIOLOGY (2006)

Add to Collection

Article Multidisciplinary Sciences

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus

J Stevens et al.

SCIENCE (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities

J Stevens et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Add to Collection

Article Multidisciplinary Sciences

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

F Li et al.

SCIENCE (2005)

Add to Collection

Review Biochemistry & Molecular Biology

Here a virus, there a virus, everywhere the same virus?

M Breitbart et al.

TRENDS IN MICROBIOLOGY (2005)

Add to Collection

Article Microbiology

Pseudomonas aeruginosa lectin LecB is located in the outer membrane and is involved in biofilm formation

D Tielker et al.

MICROBIOLOGY-SGM (2005)

Add to Collection

Review Immunology

The lectin-complement pathway - its role in innate immunity and evolution

T Fujita et al.

IMMUNOLOGICAL REVIEWS (2004)

Add to Collection

Article Multidisciplinary Sciences

Human and avian influenza viruses target different cell types in cultures of human airway epithelium

MN Matrosovich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Add to Collection

Involvement of sialoglycans in SARS-COV-2 infection: Opportunities and challenges for glyco-based inhibitors

Related references

Export Citation

Share Paper