Journal
IUBMB LIFE
Volume 74, Issue 12, Pages 1253-1263Publisher
WILEY
DOI: 10.1002/iub.2692
Keywords
drug design; glycobiology; protein structure; structural biology
Categories
Funding
- Franco-Thai Mobility Program PHCSIAM [ANR-17-EURE-0003]
- Glyco@Alps [N41A640121]
- Mahidol University
- LABoratoiresd'EXcellence ARCANE
- National Research Council ofThailand
- [46949XM]
- [ANR-15-IDEX-02]
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This article reviews the current knowledge on protein-glycan interactions that facilitate SARS-CoV-2 host entry, with a special focus on sialoglycans present on both the virions and host cell surfaces. The authors also analyze how this information provides opportunities and challenges in glyco-based inhibitors.
Viral infections have been the causes of global pandemics, including the ongoing coronavirus disease 2019, which prompted the investigation into the infection mechanisms to find treatment and aid the vaccine design. Betacoronaviruses use spike glycoprotein on their surface to bind to host receptors, aiding their host attachment and cell fusion. Protein-glycan interaction has been implicated in the viral entry mechanism of many viruses and has recently been shown in SARS-CoV-2. Here, we reviewed the current knowledge on protein-glycan interactions that facilitate SARS-CoV-2 host entry, with special interest in sialoglycans present on both the virions and host cell surfaces. We also analyze how such information provides opportunities and challenges in glyco-based inhibitors.
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