4.7 Article

Contributions of nanotechnology to the intraductal drug delivery for local treatment and prevention of breast cancer

Related references

Note: Only part of the references are listed.
Article Instruments & Instrumentation

Breast intraductal nanoformulations for treating ductal carcinoma in situ II: Dose de-escalation using a slow releasing/slow bioconverting prodrug strategy

Firas Al-Zubaydi et al.

Summary: The intraductal administration of Ciclopirox nanoformulations showed significant anti-tumor efficacy in treating DCIS, demonstrating a new potential strategy for dose de-escalation while maintaining effectiveness.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Review Medicine, General & Internal

Nipple aspirate fluid and its use for the early detection of breast cancer

Natasha Jiwa et al.

Summary: The review examines the use of new technologies to evaluate the components of nipple fluid and their potential as biomarkers in screening. New technologies can help identify metabolites that were previously difficult to identify in small volume fluids. The discovery of biomarkers in nipple aspirate fluid is attractive for assessing high-risk patients, but current evaluation is limited by poor diagnostic accuracy.

ANNALS OF MEDICINE AND SURGERY (2022)

Review Pharmacology & Pharmacy

Nanocrystals for controlled delivery: state of the art and approved drug products

Rahul S. Kalhapure et al.

Summary: Controlled/extended-release formulations offer advantages such as reduced side effects, improved therapeutic outcomes, and high patient compliance. Nanocrystals provide a versatile technology with benefits like high drug loading and ease of manufacturing, although not all drugs may be suitable for this approach. Technologies should explore converting nanocrystals into final dosage forms while preserving the benefits of small particle size and controlled release.

EXPERT OPINION ON DRUG DELIVERY (2022)

Article Multidisciplinary Sciences

X-Ray Visualization of Intraductal Ethanol-Based Ablative Treatment for Prevention of Breast Cancer in Rat Models

Elizabeth Kenyon et al.

Summary: There are limited primary interventions for breast cancer prevention, and prophylactic mastectomy is the most effective intervention for high-risk women. This study aims to demonstrate a minimally invasive intraductal procedure as a new primary intervention for breast cancer prevention.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2022)

Article Pharmacology & Pharmacy

Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis

Hisham Al-Obaidi et al.

Summary: This study presents a novel approach to enhance the penetration and antifungal activity of the antifungal drug griseofulvin. The prepared nanosuspensions significantly suppressed fungal activity and showed improved solubility of the drug. The type of surfactant and milling conditions had varied effects on permeability and particle size.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

Review Pharmacology & Pharmacy

Beyond Formulation: Contributions of Nanotechnology for Translation of Anticancer Natural Products into New Drugs

Rodrigo dos A. Miguel et al.

Summary: Nature is a rich source of medicinal compounds like doxorubicin (DOX) and paclitaxel (PTX). Nanoformulations of these drugs are cost-effective and offer improved pharmacokinetic properties and targeted delivery, resulting in reduced side effects. They can also overcome drug resistance and allow for multi-drug encapsulation for combined chemotherapy.

PHARMACEUTICS (2022)

Article Chemistry, Medicinal

Phosphatidylcholine-Based Nanoemulsions for Paclitaxel and a P-Glycoprotein Inhibitor Delivery and Breast Cancer Intraductal Treatment

Giovanna Cassone Salata et al.

Summary: This study investigated the intraductal delivery and localized treatment of breast cancer using hyaluronic acid-modified nanoemulsions that incorporate the cytotoxic agent paclitaxel and the P-glycoprotein inhibitor elacridar. The results showed that the incorporation of perillyl alcohol or tributyrin as components of the nanoemulsion oil phase increased cytotoxicity in MCF-7 cells. However, perillyl alcohol reduced nanoemulsion stability in the presence of the drugs. The nanoemulsion containing both paclitaxel and elacridar in HA and tributyrin showed increased cytotoxicity and reduced IC50 in both MCF-7 and MDA-MB-231 cells. In vivo experiments demonstrated the importance of HA in improving the retention of the nanoemulsion. Overall, this study highlights the potential applicability of the nanoemulsion for localized breast cancer management.

PHARMACEUTICALS (2022)

Article Multidisciplinary Sciences

Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study

Guannan Wang et al.

Summary: The study demonstrated potent antitumor effects of intraductal injection of HB21(Fv)-PE40 on breast cancer, providing a strong preclinical foundation for conducting feasibility and safety trials in breast cancer patients.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Review Oncology

Nonsurgical Prevention Strategies in BRCA1 and BRCA2 Mutation Carriers

Christian F. Singer

Summary: Female carriers of BRCA1 or 2 germline mutations have a high lifetime risk of developing breast and ovarian cancer. Risk-reducing surgery is effective but associated with significant side effects, prompting the search for alternative strategies. Endocrine treatments have shown effectiveness in secondary prevention, while denosumab is being investigated as a potential noninvasive strategy for primary prevention in BRCA1 mutation carriers.

BREAST CARE (2021)

Article Surgery

Longitudinal Risk Management for Patients with Increased Risk for Breast Cancer

Malcolm Su et al.

Summary: This study found that women with gene mutations, history of high-risk proliferative changes, and prior hysterectomy were more likely to choose risk reducing strategies, while age, race, and increased predicted risk of developing breast cancer were not associated with this likelihood.

JOURNAL OF SURGICAL RESEARCH (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Agriculture, Dairy & Animal Science

Animal Models for In Vivo Lactation Studies: Anatomy, Physiology and Milk Compositions in the Most Used Non-Clinical Species: A Contribution from the ConcePTION Project

Domenico Ventrella et al.

Summary: Breastfeeding importance is widely recognized, but lack of scientific data on medication transfer during lactation causes pressure on women under treatment. ConcePTION project aims to provide reliable information on medication effects during pregnancy and breastfeeding. By summarizing lactation process features in animal species, the goal is to select an appropriate species for studying drug transfer through milk.

ANIMALS (2021)

Review Biochemistry & Molecular Biology

Lipid nanovesicles for biomedical applications: 'What is in a name'?

Alexsandra Conceicao Apolinario et al.

Summary: Vesicles, self-assembled structures formed by single or multiple concentric bilayers surrounding an aqueous core, are widely used in biomedical applications. Liposomes, one of the most well-known types of vesicles, have been extensively modified for drug delivery purposes. The nomenclature of vesicles is often based on changes in lipid composition or other enhanced properties.

PROGRESS IN LIPID RESEARCH (2021)

Article Public, Environmental & Occupational Health

Understanding low chemoprevention uptake by women at high risk of breast cancer: findings from a qualitative inductive study of women's risk-reduction experiences

Tasleem J. Padamsee et al.

Summary: The study found that many high-risk women have low awareness of chemoprevention, with even lower awareness among African American women. Women who are aware of chemoprevention are more likely to have received guidance from specialists, with healthcare providers being their main source of information. Women who are reluctant to use chemoprevention often cite concerns about potential side effects and other reasons.

BMC WOMENS HEALTH (2021)

Review Pharmacology & Pharmacy

Preclinical Advances in Theranostics for the Different Molecular Subtypes of Breast Cancer

Hanyi Fang et al.

Summary: Breast cancer, the most common cancer in women globally, presents challenges in diagnosis and treatment due to its heterogeneity and drug resistance. Molecular imaging methods offer precision medicine tools, while new therapeutic targets and options are being developed to overcome resistance to standard treatments for breast cancer patients.

FRONTIERS IN PHARMACOLOGY (2021)

Article Oncology

Intraductal administration of N-methyl-N-nitrosourea as a novel rodent mammary tumor model

Dongcheng Gao et al.

Summary: The study established a rat mammary tumor model using i.duc MNU injection, resulting in predictable tumor location and better consistency. Additionally, i.duc administration of nab-PTX allowed for smaller drug doses, but produced a better drug response compared to i.v injection.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Review Pharmacology & Pharmacy

Women-specific routes of administration for drugs: A critical overview

Jose das Neves et al.

Summary: The female body presents unique anatomical features that can be utilized as valuable routes for drug administration. Understanding the possibilities and limitations of women-specific routes is crucial for the development of new therapeutic strategies that will contribute to the advancement of women's health. This article provides an overview on women-specific routes for drug administration, focusing on biological features, clinical relevance, available drug dosage forms/delivery systems, administration techniques, and recent trends in the field.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Biochemistry & Molecular Biology

Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing

Sandra Costa-Fernandez et al.

Summary: The study developed bioadhesive nanostructured lipid carriers for the management of chronic wounds in elderly individuals, effectively delivering antioxidants and antimicrobial agents to improve treatment outcomes. The results demonstrated significant localization of the carriers in damaged skin, along with antimicrobial effects and stimulation of fibroblast migration.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Review Biochemistry & Molecular Biology

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging-A Review

Marika Musielak et al.

Summary: Nanotechnology has brought new possibilities for treating and diagnosing diseases, with liposomes and metallic nanoparticles (LipoMNPs) being a key interest. However, the bio-interactions and long-term effects of hybrid nanostructures are still not well understood, hindering their clinical implementation. LipoMNPs show promise in cancer treatment and magnetic resonance imaging, with potential for theragnostic approaches combining treatment and imaging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biotechnology & Applied Microbiology

Genetic polymorphisms on the effectiveness or safety of breast cancer treatment: Clinical relevance and future perspectives

Yasmin Cura et al.

Summary: Breast cancer treatment response varies due to genetic polymorphisms, with low-activity alleles associated with poorer outcomes and the need for clinical pharmacogenetic guidelines. Polymorphisms in genes are linked to treatment effectiveness and toxicity, potentially serving as future predictive genetic biomarkers. Further studies are needed to confirm and clarify the clinical relevance of these associations.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2021)

Review Biotechnology & Applied Microbiology

Topical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us?

Gabriela Mojeiko et al.

Summary: Despite the limited pharmacological prevention strategies for breast cancer among high-risk population, delivering drugs directly to the breasts may increase drug levels in mammary tissue, improving efficacy and safety. Utilizing the breast skin as a route for drug administration shows potential for enhancing drug penetration and absorption, leading to improved outcomes in preventive therapy for breast cancer.

NANOMEDICINE (2021)

Review Oncology

Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review

Sergiusz Lukasiewicz et al.

Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, with molecular subtypes providing new insights into treatment strategies and patient stratifications that impact the management of breast cancer patients.

CANCERS (2021)

Review Pharmacology & Pharmacy

Formulation aspects of intravenous nanosuspensions

Dipeekakumari Patel et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Oncology

Intraductal Therapy in Breast Cancer: Current Status and Future Prospective

Xin-Wen Kuang et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2020)

Review Zoology

Breast cancer animal models and applications

Li Zeng et al.

ZOOLOGICAL RESEARCH (2020)

Article Nanoscience & Nanotechnology

Alginate nanoparticles as non-toxic delivery system for miltefosine in the treatment of candidiasis and cryptococcosis

Cristina de Castro Spadari et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Review Biochemistry & Molecular Biology

Paclitaxel's Mechanistic and Clinical Effects on Breast Cancer

Tala M. Abu Samaan et al.

BIOMOLECULES (2019)

Review Engineering, Biomedical

Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies

Eleonora Calzoni et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2019)

Review Nanoscience & Nanotechnology

A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

Malathi Mathiyazhakan et al.

NANO-MICRO LETTERS (2018)

Review Nanoscience & Nanotechnology

A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

Malathi Mathiyazhakan et al.

NANO-MICRO LETTERS (2018)

Review Medicine, Research & Experimental

Drug Delivery in Cancer Therapy, Quo Vadis?

Zheng-Rong Lu et al.

MOLECULAR PHARMACEUTICS (2018)

Article Oncology

Are There Alternative Strategies for the Local Management of Ductal Carcinoma in Situ?

Kelly J. Rosso et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2018)

Review Chemistry, Multidisciplinary

Nanoemulsion: Concepts, development and applications in drug delivery

Yuvraj Singh et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Materials Science, Biomaterials

Polymeric nanoparticles: A study on the preparation variables and characterization methods

Carina I. C. Crucho et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Review Oncology

Paradigm Shift toward Reducing Overtreatment of Ductal Carcinoma In Situ of Breast

Yasuaki Sagara et al.

FRONTIERS IN ONCOLOGY (2017)

Review Pharmacology & Pharmacy

Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism

Ann-Marie Meredith et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)

Article Oncology

Cancer statistics: Breast cancer in situ

Elizabeth M. Ward et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2015)

Article Oncology

Addressing overtreatment of screen detected DCIS; the LORIS trial

Adele Francis et al.

EUROPEAN JOURNAL OF CANCER (2015)

Review Oncology

Of Mice and Women: A Comparative Tissue Biology Perspective of Breast Stem Cells and Differentiation

Gabriela Dontu et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2015)

Article Oncology

Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ

Steven A. Narod et al.

JAMA ONCOLOGY (2015)

Review Oncology

An overview of doxorubicin formulations in cancer therapy

Sangeeta Rivankar

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2014)

Article Oncology

A Feasibility Study of the Intraductal Administration of Chemotherapy

Susan M. Love et al.

CANCER PREVENTION RESEARCH (2013)

Article Oncology

Intraductal Therapy of Ductal Carcinoma In Situ: A Presurgery Study

M. Ellen Mahoney et al.

CLINICAL BREAST CANCER (2013)

Review Pharmacology & Pharmacy

Overview of the therapeutic potential of piplartine (piperlongumine)

Daniel P. Bezerra et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Review Chemistry, Multidisciplinary

Doxil® - The first FDA-approved nano-drug: Lessons learned

Yechezkel (Chezy) Barenholz

JOURNAL OF CONTROLLED RELEASE (2012)

Article Chemistry, Multidisciplinary

Influence of Molecular Size on the Retention of Polymeric Nanocarrier Diagnostic Agents in Breast Ducts

Yashveer Singh et al.

PHARMACEUTICAL RESEARCH (2012)

Article Chemistry, Physical

Nanoemulsions versus microemulsions: terminology, differences, and similarities

David Julian McClements

SOFT MATTER (2012)

Article Oncology

Global Cancer Statistics

Ahmedin Jemal et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

Review Oncology

Preventive therapy for breast cancer: a consensus statement

Jack Cuzick et al.

LANCET ONCOLOGY (2011)

Review Polymer Science

Polymer nanoparticles: Preparation techniques and size-control parameters

J. Prasad Rao et al.

PROGRESS IN POLYMER SCIENCE (2011)

Article Cell Biology

Preclinical and Clinical Evaluation of Intraductally Administered Agents in Early Breast Cancer

Vered Stearns et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Review Oncology

Status of Intraductal Therapy for Ductal Carcinoma in Situ

Meghan Flanagan et al.

CURRENT BREAST CANCER REPORTS (2010)

Review Biochemistry & Molecular Biology

Doxorubicin: The Good, the Bad and the Ugly Effect

Cristina Carvalho et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Article Oncology

Technical enhancements to breast ductal lavage

Julianne Tondre et al.

ANNALS OF SURGICAL ONCOLOGY (2008)

Review Oncology

The Role of Mammary Ductoscopy in Breast Cancer: a Review of the Literature

Edna Kapenhas-Valdes et al.

ANNALS OF SURGICAL ONCOLOGY (2008)

Review Chemistry, Multidisciplinary

Intravesical treatments of bladder cancer: Review

Zancong Shen et al.

PHARMACEUTICAL RESEARCH (2008)

Article Oncology

Breast duct anatomy in the human nipple: Three-dimensional patterns and clinical implications

Jennifer E. Rusby et al.

BREAST CANCER RESEARCH AND TREATMENT (2007)

Article Pathology

The theory, of the sick breast lobe and the possible consequences

Tibor Tot

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY (2007)

Article Pharmacology & Pharmacy

Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux

Mahesh D. Chavanpatil et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2006)

Review Oncology

The natural history of ductal carcinoma in situ of the breast:: a review

B Erbas et al.

BREAST CANCER RESEARCH AND TREATMENT (2006)

Article Oncology

Ductal access for prevention and therapy of mammary tumors.

S Murata et al.

CANCER RESEARCH (2006)

Article Oncology

Anatomy of the nipple and breast ducts revisited

SM Love et al.

CANCER (2004)

Article Oncology

Ductal lavage findings in women with known breast cancer undergoing mastectomy

SA Khan et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2004)

Article Surgery

Patient and duct selection for nipple duct lavage

AJ Maddux et al.

AMERICAN JOURNAL OF SURGERY (2004)

Article Pharmacology & Pharmacy

Novel ceramide analogs as potential chemotherapeutic agents in breast cancer

AP Struckhoff et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)

Article Oncology

Nipple aspirate fluid cytology in breast carcinoma

S Krishnamurthy et al.

CANCER CYTOPATHOLOGY (2003)