4.7 Review

Physiological relevance of in-vitro cell-nanoparticle interaction studies as a predictive tool in cancer nanomedicine research

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Revisiting the outstanding questions in cancer nanomedicine with a future outlook

M. S. Sudheesh et al.

Summary: Cancer nanomedicine holds great promise in addressing the challenges of traditional chemotherapy, utilizing the unique properties of nanoparticles. However, despite significant progress in understanding nanoscale properties, there are limited success stories in terms of clinical efficacy and patient survival. Existing paradigms in nanomedicine, such as EPR, stealth effect, and immunocompatibility, have faced recent scrutiny.

NANOSCALE ADVANCES (2022)

Review Oncology

Microfluidics meets 3D cancer cell migration

Pranav Mehta et al.

Summary: Early stages of metastasis involve complex and coordinated migration of invasive tumor cells within the tumor microenvironment. Advanced 3D matrix-based microfluidic models are advantageous in studying tumor progression events and investigating collective cancer cell migration and invasion. Microfluidic strategies have evolved to address the physiological complexities of the TME and visualize the migration modes of various tumor cells.

TRENDS IN CANCER (2022)

Review Oncology

Current methods in translational cancer research

Michael W. Lee et al.

Summary: Recent advancements in pre-clinical screening tools have led to a new era in drug development, with more accurate prediction of clinical effects and adverse events for candidate therapeutic agents. However, careful evaluation is necessary to determine the individual merits of these translational research tools to provide appropriate information for clinical researchers to conduct pre-clinical screening in an accelerated and rational manner.

CANCER AND METASTASIS REVIEWS (2021)

Article Multidisciplinary Sciences

Real-time monitoring of extracellular ATP in bacterial cultures using thermostable luciferase

Julian Ihssen et al.

Summary: Adenosine triphosphate (ATP) is a crucial indicator of cell viability. Real-time monitoring of extracellular ATP (eATP) release by bacteria using engineered luciferase can provide insights into bacterial physiology and susceptibility to antibiotics. This method offers faster and more sensitive antimicrobial susceptibility testing compared to conventional methods.

PLOS ONE (2021)

Review Biochemistry & Molecular Biology

An expanded universe of cancer targets

William C. Hahn et al.

Summary: Characterization of cancer genomes has provided insight into somatically altered genes across tumors, but the function of most cancer alleles remains mysterious and does not impact therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that therapeutic targets engendered by non-oncogene dependencies are more diverse than recurrently mutated genes, providing new opportunities for clinical translation.
Article Multidisciplinary Sciences

Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration

Stephanie M. Kong et al.

Summary: The stiffness of nanoparticles plays a crucial role in drug delivery, affecting circulation time, tumor accumulation, and penetration. Layer-by-layer nanoparticles can modulate stiffness by adjusting the mechanical properties of the core, leading to improved tumor targeting and therapeutic outcomes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Nanoscience & Nanotechnology

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

Joshua J. Rennick et al.

Summary: Endocytosis is crucial for the cellular uptake of therapeutic nanomedicines, but current understanding and study of these mechanisms are limited. The use of nonspecific inhibitors presents challenges, and alternative genetic approaches may offer more robust insights into endocytic pathways. Future studies at the intersection of cell biology and nanomedicine are needed to improve nanoparticle therapies.

NATURE NANOTECHNOLOGY (2021)

Review Immunology

Building the Next Generation of Humanized Hemato-Lymphoid System Mice

Tijana Martinov et al.

Summary: This passage discusses the development principles and challenges of humanized mouse models, focusing on increasing mouse tolerance to human grafts and addressing functional interactions between human immunity and mouse hosts.

FRONTIERS IN IMMUNOLOGY (2021)

Article Polymer Science

Stiffness-Dependent Intracellular Location of Cylindrical Polymer Brushes

Antoine Niederberger et al.

Summary: Two rod-like poly[(ethylene glycol) methyl ether methacrylate] (PEGMA)-based CPBs with varying stiffness were synthesized and their differences in particle stiffness were assessed using small angle neutron scattering (SANS). It was found that stiffer CPBs tended to gravitate towards the mitochondria, while CPBs with reduced stiffness were present in different intracellular vesicles.

MACROMOLECULAR RAPID COMMUNICATIONS (2021)

Article Biotechnology & Applied Microbiology

Cancer nanomedicine developed from total human serum: a novel approach for making personalized nanomedicine

Jyotsna Thayath et al.

Summary: The study team developed a method to convert total blood serum into chemo drug-loaded nanoparticles and demonstrated its significant antitumor efficacy in vitro and in vivo.

NANOMEDICINE (2021)

Review Pharmacology & Pharmacy

The past, present, and future of breast cancer models for nanomedicine development

Paz Boix-Montesinos et al.

Summary: Despite recent advancements in nanomedicine for breast cancer treatment and promising results in pre-clinical models, clinical trials often face challenges. Innovative cell culture strategies and consideration of critical parameters for in vivo evaluation are essential to improve the clinical translation efficiency of nanomedicines in breast cancer treatment.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Biochemistry & Molecular Biology

Commentary: Revisiting nanoparticle-assay interference: There's plenty of room at the bottom for misinterpretation

T. J. MacCormack et al.

Summary: Engineered nanomaterials have unique properties that can interfere with biochemical assays, affecting data quality and leading to misinterpretations. Understanding the physicochemical properties of nanomaterials is crucial for validating assay protocols.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2021)

Article Chemistry, Physical

Stiffness-tuneable nanocarriers for controlled delivery of ASC-J9 into colorectal cancer cells

Mhd Anas Tomeh et al.

Summary: A novel stiffness-tuneable core-shell nanocarrier composed of silk fibroin (SF) and sodium alginate (SA) was developed for enhanced cellular uptake and controlled release of hydrophobic anticancer agent ASC-J9, showing high encapsulation efficiency and physical stability. The stiffness of the nanocarriers significantly impacted their cellular uptake and anticancer efficacy, making them promising for cancer therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Editorial Material Biochemistry & Molecular Biology

Immersion in the search for effective cancer immunotherapies

Steven A. Rosenberg

MOLECULAR MEDICINE (2021)

Article Chemistry, Multidisciplinary

Sources of variability in nanoparticle uptake by cells

Christoffer Aberg et al.

Summary: The uptake of nanoparticles by cells is correlated with cell size within a cell population, but other cellular characteristics also contribute to cell-to-cell variability. These characteristics are more specific to the type of object being taken up, such as nanoparticles or proteins, complicating their detailed identification.

NANOSCALE (2021)

Article Multidisciplinary Sciences

The synergistic interference effect of silica nanoparticles concentration and the wavelength of ELISA on the colorimetric assay of cell toxicity

Fariba Abbasi et al.

Summary: The MTT assay is commonly used for determining cell toxicity, but the interference effect of SiO2 nanoparticles and wavelength has a synergistic effect on this method. The concentration of SiO2 nanoparticles is a confounding factor in colorimetric for MTT assay.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity

Danielle F. Mello et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Correction Nanoscience & Nanotechnology

A Polymer-Protein Core-Shell Nanomedicine for Inhibiting Cancer Migration Followed by Photo-Triggered Killing (vol 10, pg 1401, 2014)

Ranjith Ramachandran et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

Nanoparticle elasticity regulates phagocytosis and cancer cell uptake

Yue Hui et al.

SCIENCE ADVANCES (2020)

Article Pharmacology & Pharmacy

Interference: A Much-Neglected Aspect in High-Throughput Screening of Nanoparticles

Charlene Andraos et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2020)

Article Medicine, Research & Experimental

PDX-derived organoids model in vivo drug response and secrete biomarkers

Ling Huang et al.

JCI INSIGHT (2020)

Review Chemistry, Multidisciplinary

From 2D to 3D Cancer Cell Models-The Enigmas of Drug Delivery Research

Indra Van Zundert et al.

NANOMATERIALS (2020)

Review Biochemistry & Molecular Biology

Is It Time to Start Transitioning From 2D to 3D Cell Culture?

Caleb Jensen et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Multidisciplinary Sciences

Nanoparticle administration method in cell culture alters particle-cell interaction

Thomas L. Moore et al.

SCIENTIFIC REPORTS (2019)

Review Pharmacology & Pharmacy

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Nathan D. Donahue et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

Article Chemistry, Multidisciplinary

Prevention of Dominant IgG Adsorption on Nanocarriers in IgG-Enriched Blood Plasma by Clusterin Precoating

Domenik Prozeller et al.

ADVANCED SCIENCE (2019)

Article Chemistry, Multidisciplinary

Revisiting cell-particle association in vitro: A quantitative method to compare particle performance

Matthew Faria et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Nanoscience & Nanotechnology

Effect of Cell Age on Uptake and Toxicity of Nanoparticles: The Overlooked Factor at the Nanobio Interface

Parisa Foroozandeh et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Article Chemistry, Multidisciplinary

Macro-nanomedicine: Targeting the big picture

Twan Lammers

JOURNAL OF CONTROLLED RELEASE (2019)

Review Medicine, General & Internal

Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis

Gwang Hun Jeong et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Oncology

Modelling cancer in microfluidic human organs-on-chips

Alexandra Sontheimer-Phelps et al.

NATURE REVIEWS CANCER (2019)

Article Chemistry, Multidisciplinary

Modulating Phagocytic Cell Sequestration by Tailoring Nanoconstruct Softness

Roberto Palomba et al.

ACS NANO (2018)

Article Chemistry, Multidisciplinary

Effect of Cell Sex on Uptake of Nanoparticles: The Overlooked Factor at the Nanobio Interface

Vahid Serpooshan et al.

ACS NANO (2018)

Article Nanoscience & Nanotechnology

Gold nanoparticles: Distribution, bioaccumulation and toxicity. In vitro and in vivo studies

Carlos Lopez-Chaves et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Article Multidisciplinary Sciences

Nanoparticle elasticity directs tumor uptake

Peng Guo et al.

NATURE COMMUNICATIONS (2018)

Article Nanoscience & Nanotechnology

Roadmap and strategy for overcoming infusion reactions to nanomedicines

Janos Szebeni et al.

NATURE NANOTECHNOLOGY (2018)

Article Engineering, Biomedical

MRI analysis to map interstitial flow in the brain tumor microenvironment

Kathryn M. Kingsmore et al.

APL BIOENGINEERING (2018)

Review Chemistry, Multidisciplinary

Nanomedicine for prostate cancer using nanoemulsion: A review

Aravindsiva Sasikumar et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Chemistry, Multidisciplinary

Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model

Altug Ozcelikkale et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Review Nanoscience & Nanotechnology

In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles

Altug Ozcelikkale et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2017)

Article Biotechnology & Applied Microbiology

The presence of residual gold nanoparticles in samples interferes with the RT-qPCR assay used for gene expression profiling

Natasha M. Sanabria et al.

JOURNAL OF NANOBIOTECHNOLOGY (2017)

Article Biophysics

Dynamics of nanoparticle diffusion and uptake in three-dimensional cell cultures

Valentina Belli et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2017)

Review Biotechnology & Applied Microbiology

In-vitro in-vivo correlation (IVIVC) in nanomedicine: Is protein corona the missing link?

Priyanka Jain et al.

BIOTECHNOLOGY ADVANCES (2017)

Article Chemistry, Multidisciplinary

Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery

Pranay Agarwal et al.

ACS NANO (2017)

Article Chemistry, Multidisciplinary

Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance

Marc P. Kai et al.

ACS NANO (2016)

Review Chemistry, Multidisciplinary

Controlling the Stealth Effect of Nanocarriers through Understanding the Protein Corona

Susanne Schoettler et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Review Oncology

Humanized Mouse Xenograft Models: Narrowing the Tumor-Microenvironment Gap

J. Jason Morton et al.

CANCER RESEARCH (2016)

Article Pharmacology & Pharmacy

The MTT and Crystal Violet Assays: Potential Confounders in Nanoparticle Toxicity Testing

A. Almutary et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2016)

Article Nanoscience & Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

Susanne Schoettler et al.

NATURE NANOTECHNOLOGY (2016)

Article Cell & Tissue Engineering

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

Matthew J. Ware et al.

TISSUE ENGINEERING PART C-METHODS (2016)

Review Oncology

Mouse models in oncoimmunology

Laurence Zitvogel et al.

NATURE REVIEWS CANCER (2016)

Review Oncology

The Role of Stroma in Tumor Development

Zena Werb et al.

CANCER JOURNAL (2015)

Review Chemistry, Multidisciplinary

Nanoparticle colloidal stability in cell culture media and impact on cellular interactions

Thomas L. Moore et al.

CHEMICAL SOCIETY REVIEWS (2015)

Review Medicine, Research & Experimental

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

Douglas Marvel et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Peripheral Vascular Disease

Evaluation of gold nanoparticles toxicity towards human endothelial cells under static and flow conditions

Caterina Fede et al.

MICROVASCULAR RESEARCH (2015)

Article Chemistry, Multidisciplinary

Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake

Jiashu Sun et al.

ADVANCED MATERIALS (2015)

Article Chemistry, Multidisciplinary

Stiffness-Dependent In Vitro Uptake and Lysosomal Acidification of Colloidal Particles

Raimo Hartmann et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Review Chemistry, Multidisciplinary

EPR: Evidence and fallacy

Joseph W. Nichols et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Article Multidisciplinary Sciences

Widespread Nanoparticle-Assay Interference: Implications for Nanotoxicity Testing

Kimberly J. Ong et al.

PLOS ONE (2014)

Article Chemistry, Multidisciplinary

Real-Time Nanoparticle-Cell Interactions in Physiological Media by Atomic Force Microscopy

Georgios Pyrgiotakis et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2014)

Review Oncology

Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer

P. P. Provenzano et al.

BRITISH JOURNAL OF CANCER (2013)

Article Medicine, Research & Experimental

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

Stephen W. Jones et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Chemistry, Multidisciplinary

Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency

Anna Lesniak et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Review Immunology

Innate and adaptive immune cells in the tumor microenvironment

Thomas F. Gajewski et al.

NATURE IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

Evaluation of Nanoparticle Uptake in Co-culture Cancer Models

Elisabete C. Costa et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

Alexandre Albanese et al.

NATURE COMMUNICATIONS (2013)

Review Cell Biology

The extracellular matrix: A dynamic niche in cancer progression

Pengfei Lu et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Chemistry, Multidisciplinary

The delivered dose: Applying particokinetics to in vitro investigations of nanoparticle internalization by macrophages

Raha Ahmad Khanbeigi et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Editorial Material Biochemistry & Molecular Biology

The tumor microenvironment controls drug sensitivity

Arne Ostman

NATURE MEDICINE (2012)

Article Nanoscience & Nanotechnology

The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles

Eun Chul Cho et al.

NATURE NANOTECHNOLOGY (2011)

Article Pharmacology & Pharmacy

Validation of an LDH assay for assessing nanoparticle toxicity

Xianglu Han et al.

TOXICOLOGY (2011)

Article Pharmacology & Pharmacy

Biophysical characterization of a liposomal formulation of cytarabine and daunorubicin

Awa Dicko et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)

Review Oncology

Delivering nanomedicine to solid tumors

Rakesh K. Jain et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Article Engineering, Environmental

Characterizing Manufactured Nanoparticles in the Environment: Multimethod Determination of Particle Sizes

Rute F. Domingos et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2009)

Review Genetics & Heredity

Confounding experimental considerations in nanogenotoxicology

S. H. Doak et al.

MUTAGENESIS (2009)

Review Multidisciplinary Sciences

Designing materials to direct stem-cell fate

Matthias P. Lutolf et al.

NATURE (2009)

Article Chemistry, Physical

Effect of mechanical properties of hydrogel nanoparticles on macrophage cell uptake

Xavier Banquy et al.

SOFT MATTER (2009)

Article Pharmacology & Pharmacy

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

N. A. Monteiro-Riviere et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

Review Medicine, Research & Experimental

Altered macrophage differentiation and immune dysfunction in tumor development

Antonio Sica et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Medicine, Research & Experimental

Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

Markus Loeffler et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Multidisciplinary Sciences

Stromal fibroblasts in cancer initiation and progression

NA Bhowmick et al.

NATURE (2004)

Article Critical Care Medicine

Innate immune response in Th1- and Th2-dominant mouse strains

H Watanabe et al.

SHOCK (2004)

Article Biochemistry & Molecular Biology

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

E Brown et al.

NATURE MEDICINE (2003)