4.2 Review

Neuromyelitis optica spectrum disorder: pathophysiological approach

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Spectrum of sublytic astrocytopathy in neuromyelitis optica

Yong Guo et al.

Summary: Neuromyelitis optica is an autoimmune inflammatory disorder that affects CNS astrocytes. This study reveals the complex astrogliotic reactions and their role in the evolution and potential for repair of lesions, independent of aquaporin-4 loss or lysis.

BRAIN (2022)

Article Clinical Neurology

Inebilizumab for treatment of neuromyelitis optica spectrum disorder in patients with prior rituximab use from the N-MOmentum Study

Eoin P. Flanagan et al.

Summary: This study evaluated the efficacy and tolerability of Inebilizumab in NMOSD patients who had previously been treated with rituximab. The findings suggest that Inebilizumab is effective in these patients, with most infections occurring in those who had prior rituximab exposure. Further research is needed to assess potential safety concerns, including infection risk, in patients with rituximab experience.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Article Genetics & Heredity

Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation

Ali Maisam Afzali et al.

Summary: AQP4 plays a critical role in neuroinflammation, and lack of AQP4 in the retina leads to sustained retinal thickening, hyperperfusion, albumin extravasation, and upregulation of GFAP. Furthermore, retinal ganglion cell loss is more severe in the absence of AQP4.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders

Mona Shahriari et al.

Summary: This paper discusses the imaging characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and compares them with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). It highlights the intracranial, intraorbital, and spinal features of MOGAD, emphasizing the importance of early accurate diagnosis for prognosis and treatment planning different from NMOSD and MS.

AMERICAN JOURNAL OF ROENTGENOLOGY (2021)

Review Clinical Neurology

Recent progress in maintenance treatment of neuromyelitis optica spectrum disorder

Trygve Holmoy et al.

Summary: For NMOSD patients, monoclonal antibodies that deplete B cells or interfere with interleukin 6 signaling have superior efficacy compared to placebo; Rituximab, tocilizumab, and to some extent eculizumab have well-known safety profiles; Rituximab and azathioprine may be safe during pregnancy.

JOURNAL OF NEUROLOGY (2021)

Review Multidisciplinary Sciences

Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis

Marcos Papais Alvarenga et al.

Summary: The HLA association study of Neuromyelitis Optica suggests that different ethnicities have an impact on genetic susceptibility, with DRB1*03:01 being primarily associated in Western populations and DPB1*05:01 in Asians. The differences in genetic susceptibility between Multiple Sclerosis and Neuromyelitis Optica were confirmed in Afro descendants. The DRB1*03 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.

SCIENTIFIC REPORTS (2021)

Review Clinical Neurology

Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke

Shufen Zhang et al.

Summary: Astrocytes play crucial roles in ischemic stroke, closely related to factors such as blood-brain barrier, growth factors, gap junctions, AQP4, and glial scars. The latest literature has summarized the potential roles of astrocytes after ischemic stroke.

EUROPEAN NEUROLOGY (2021)

Review Immunology

Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies

Edgar Carnero Contentti et al.

Summary: Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease characterized by acute optic neuritis and transverse myelitis. It is caused by a pathogenic serum IgG antibody targeting the water channel aquaporin 4 (AQP4). Recent studies have shown significant progress in identifying new treatments for NMOSD.

JOURNAL OF NEUROINFLAMMATION (2021)

Review Clinical Neurology

Review: Recent advances in the understanding of the pathophysiology of neuromyelitis optica spectrum disorder

V. T. W. Chang et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2020)

Article Neurosciences

Astrocytes Are Required for Oligodendrocyte Survival and Maintenance of Myelin Compaction and Integrity

Reshmi Tognatta et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Obstetrics & Gynecology

Maternal and neonatal outcomes among pregnant women with myasthenia gravis

Laura Nicholls-Dempsey et al.

JOURNAL OF PERINATAL MEDICINE (2020)

Review Clinical Neurology

Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology

Kazuo Fujihara et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

Article Medicine, Research & Experimental

Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica

John Soltys et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Medicine, General & Internal

Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder

S. J. Pittock et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Neurosciences

AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding

Claudia Palazzo et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Article Medicine, General & Internal

Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder

Takashi Yamamura et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Clinical Neurology

Autoimmune diseases associated with Neuromyelitis Optica Spectrum Disorders: A literature review

Sareh Shahmohammadi et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Editorial Material Clinical Neurology

Worldwide prevalence of neuromyelitis optica spectrum disorders

Masahiro Mori et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

Article Clinical Neurology

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

Nadja Borisow et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Article Clinical Neurology

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

Nadja Borisow et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Article Multidisciplinary Sciences

Autoantibody-induced internalization of CNS AQP4 water channel and EAAT2 glutamate transporter requires astrocytic Fc receptor

Shannon R. Hinson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Anatomy & Morphology

Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions

Shirin Katoozi et al.

BRAIN STRUCTURE & FUNCTION (2017)

Review Clinical Neurology

Atypical inflammatory demyelinating syndromes of the CNS

Todd A. Hardy et al.

LANCET NEUROLOGY (2016)

Article Clinical Neurology

Role of membrane complement regulators in neuromyelitis optica

Samira Saadoun et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Article Clinical Neurology

Short Myelitis Lesions in Aquaporin-4-IgG-Positive Neuromyelitis Optica Spectrum Disorders

Eoin P. Flanagan et al.

JAMA NEUROLOGY (2015)

Article Clinical Neurology

Role of membrane complement regulators in neuromyelitis optica

Samira Saadoun et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Review Clinical Neurology

Conventional and Advanced Imaging in Neuromyelitis Optica

Y. Barnett et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2014)

Article Clinical Neurology

The Pathology of an Autoimmune Astrocytopathy: Lessons Learned from Neuromyelitis Optica

Claudia F. Lucchinetti et al.

BRAIN PATHOLOGY (2014)

Article Neurosciences

Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury

Nithi Asavapanumas et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)

Review Neurosciences

Aquaporin water channels in the nervous system

Marios C. Papadopoulos et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Review Physiology

PHYSIOLOGICAL ROLES OF AQUAPORIN-4 IN BRAIN

Erlend A. Nagelhus et al.

PHYSIOLOGICAL REVIEWS (2013)

Review Neurosciences

Aquaporin-4 and epilepsy

Devin K. Binder et al.

Article Developmental Biology

The Brown Norway opticospinal model of demyelination: Does it mimic multiple sclerosis or neuromyelitis optica?

N. Collongues et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

Complement-dependent Cytotoxicity in Neuromyelitis Optica Requires Aquaporin-4 Protein Assembly in Orthogonal Arrays

Puay-Wah Phuan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Neurosciences

Neuromyelitis Optica: An Antibody-Mediated Disorder of the Central Nervous System

Jiwon Oh et al.

NEUROLOGY RESEARCH INTERNATIONAL (2012)

Article Biochemistry & Molecular Biology

Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation

Lihua Li et al.

FASEB JOURNAL (2011)

Article Biochemistry & Molecular Biology

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

Jonathan M. Crane et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Clinical Neurology

Neuromyelitis optica-IgG (aquaporin-4) autoantibodies in immune mediated optic neuritis

A. Petzold et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)

Article Clinical Neurology

Neuromyelitis Optica: Pathogenicity of Patient Immunoglobulin In Vivo

Monika Bradl et al.

ANNALS OF NEUROLOGY (2009)

Review Biochemistry & Molecular Biology

Cellular Elements of the Blood-Brain Barrier

Jorge Correale et al.

NEUROCHEMICAL RESEARCH (2009)

Article Multidisciplinary Sciences

Crystal structure of human aquaporin 4 at 1.8 Å and its mechanism of conductance

Joseph D. Ho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Clinical Neurology

Aquaporin-4 antibodies in neuromyelitis Optica and longitudinally extensive transverse myelitis

Patrick Waters et al.

ARCHIVES OF NEUROLOGY (2008)

Article Clinical Neurology

Neuromyelitis Optica and non-organ-specific Autoimmunity

Sean J. Pittock et al.

ARCHIVES OF NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

The molecular composition of square Arrays

Jan Gunnar Sorbo et al.

BIOCHEMISTRY (2008)

Article Clinical Neurology

Characteristics of Devic's disease (neuromyelitis optica) in Mexico

Jose Flores Rivera et al.

JOURNAL OF NEUROLOGY (2008)

Review Clinical Neurology

Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica

Sven Jarius et al.

NATURE CLINICAL PRACTICE NEUROLOGY (2008)

Article Clinical Neurology

Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression

Sean J. Pittock et al.

ARCHIVES OF NEUROLOGY (2006)

Article Clinical Neurology

Revised diagnostic criteria for neuromyelitis optica

D. M. Wingerchuk et al.

NEUROLOGY (2006)

Article Cell Biology

Involvement of aquaporin-4 in astroglial cell migration and glial scar formation

S Saadoun et al.

JOURNAL OF CELL SCIENCE (2005)

Article Clinical Neurology

Activation of humoral immunity and eosinophils in neuromyelitis optica

J Correale et al.

NEUROLOGY (2004)

Review Neurosciences

The molecular basis of water transport in the brain

M Amiry-Moghaddam et al.

NATURE REVIEWS NEUROSCIENCE (2003)

Article Clinical Neurology

Is Devic's neuromyelitis optica a separate disease? A comparative study with multiple sclerosis

J de Seze et al.

MULTIPLE SCLEROSIS JOURNAL (2003)

Article Clinical Neurology

Familial neuromyelitis optics (Devic's syndrome) with late onset in Japan

K Yamakawa et al.

NEUROLOGY (2000)

Article Biochemistry & Molecular Biology

Glial cells and volume transmission in the CNS

E Syková et al.

NEUROCHEMISTRY INTERNATIONAL (2000)

Article Biochemistry & Molecular Biology

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

GT Manley et al.

NATURE MEDICINE (2000)