CD83 Regulates the Immune Responses in Inflammatory Disorders

Activating the immune system plays an important role in maintaining physiological homeostasis and defending the body against harmful infections. However, abnormalities in the immune response can lead to various immunopathological responses and severe inflammation. The activation of dendritic cells (DCs) can influence immunological responses by promoting the differentiation of T cells into various functional subtypes crucial for the eradication of pathogens. CD83 is a molecule known to be expressed on mature DCs, activated B cells, and T cells. Two isotypes of CD83, a membrane-bound form and a soluble form, are subjects of extensive scientific research. It has been suggested that CD83 is not only a ubiquitous co-stimulatory molecule but also a crucial player in monitoring and resolving inflammatory reactions. Although CD83 has been involved in immunological responses, its functions in autoimmune diseases and effects on pathogen immune evasion remain unclear. Herein, we outline current immunological findings and the proposed function of CD83 in inflammatory disorders.

Automated summary

Activating the immune system is important for maintaining homeostasis and defending against infections, but abnormalities in the immune response can lead to harmful immunopathological responses and severe inflammation. Dendritic cells play a role in influencing immune responses through the differentiation of T cells. CD83, expressed on mature dendritic cells, activated B cells, and T cells, has been studied extensively and has been suggested to have functions in co-stimulation and resolving inflammatory reactions. However, its roles in autoimmune diseases and pathogen immune evasion are not fully understood. This article outlines current findings and proposed functions of CD83 in inflammatory disorders.