4.7 Review

Mechanistic Insights, Treatment Paradigms, and Clinical Progress in Neurological Disorders: Current and Future Prospects

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Extracellular vesicles and the Stress System

Evanthia A. Makrygianni et al.

Summary: Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that are released by various cell types and contain biomolecules. They play a role in intercellular communication and can cross the blood brain barrier. Neuroendocrine cells are specialized neurons that secrete hormones directly into blood vessels, facilitating neuroendocrine integration.

NEUROENDOCRINOLOGY (2023)

Article Clinical Neurology

Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease

Linda Soderberg et al.

Summary: Immunotherapy targeting amyloid-beta (A ss) shows promise in treating Alzheimer's disease (AD). This study characterized the binding properties of three antibodies (lecanemab, aducanumab, and gantenerumab) to various A ss species and found different binding preferences, which may explain the variability in clinical efficacy and side effects observed for these antibodies.

NEUROTHERAPEUTICS (2023)

Article Clinical Neurology

Lecanemab, Aducanumab, and Gantenerumab - Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer's Disease

Linda Soderberg et al.

Summary: The study revealed different binding profiles of lecanemab, aducanumab, and gantenerumab to various species of Aβ, which may explain the varying clinical outcomes and side effects observed for these antibodies.

NEUROTHERAPEUTICS (2023)

Article Public, Environmental & Occupational Health

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019

Emma Nichols et al.

Summary: With projected trends in population ageing and growth, the number of people with dementia is expected to increase. Understanding the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritization, with a focus on potentially modifiable risk factors.

LANCET PUBLIC HEALTH (2022)

Review Clinical Neurology

Reimagining cholinergic therapy for Alzheimer's disease

Ezio Giacobini et al.

Summary: The review discusses the use of cholinesterase inhibitors in the treatment of Alzheimer's disease, the role of the basal forebrain cholinergic system in cognition, and potential future therapies targeting the NGF metabolic pathway and M1 muscarinic receptor. It provides an updated view of the cholinergic-oriented therapy of Alzheimer's disease and suggests new alternatives to enhance its clinical effect.

BRAIN (2022)

Review Biochemistry & Molecular Biology

The Antioxidant Effect of the Metal and Metal-Oxide Nanoparticles

Xuemei Ge et al.

Summary: This paper illustrates the excellent performance of inorganic nanoparticles in antioxidant effect, including smaller and controllable sizes, flexibility to be modified, relative low toxicity and ease of preparation. The antioxidant mechanism of these nanoparticles, such as antioxidant enzyme-mimetic activity and antioxidant ROS/RNS scavenging activity, is introduced. The paper summarizes the antioxidant effects and applications of several nanoparticles and investigates the potential toxicity for further applications. Furthermore, the future directions of utilizing these inorganic nanoparticles in fields such as medicine, cosmetic and functional food additives are explored.

ANTIOXIDANTS (2022)

Review Biochemistry & Molecular Biology

Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene

Jaya Bagaria et al.

Summary: PSEN1 plays a crucial role in early onset Alzheimer's disease, affecting various processes beyond amyloid precursor protein cleavage. Numerous mutations have been identified in PSEN1, leading to diverse clinical phenotypes. The pathogenic nature of these mutations can be categorized according to guidelines, though some remain unclassified due to their rarity and potential involvement of genetic modifiers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

News Item Medicine, General & Internal

New Research Partnership for ALS, Rare Neurodegenerative Diseases

Howard D. Larkin

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Review Cell Biology

Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage

Yoshimichi Sato et al.

Summary: The neurovascular unit (NVU) depicts the relationship between brain cells and the vascular structure, regulating cerebral blood flow and maintaining brain homeostasis. Dysregulation of the NVU is a key pathological feature underlying neurological disorders. Understanding NVU dysfunction and remodeling is crucial for targeted therapy design and relevant research progress.

CELLS (2022)

Article Public, Environmental & Occupational Health

Mental health impact of COVID-19 on Saudi families and children with special educational needs and disabilities in Saudi Arabia: A national perspective

Shuliweeh Alenezi et al.

Summary: The COVID-19 pandemic has had a significant impact on families with special educational needs and disabilities, resulting in increased anxiety levels and concerns. Both children with SEND and their parents experienced higher anxiety levels at the start of the pandemic compared to before.

FRONTIERS IN PUBLIC HEALTH (2022)

Review Chemistry, Multidisciplinary

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease

Feng Zhang et al.

Summary: As the population ages, Alzheimer's disease will impose social and economic burdens globally. Current drugs for AD only provide symptomatic relief with limited impact on disease progression. Therefore, early diagnosis and multi-target interventions are crucial for promising outcomes in AD treatment.

ACTA PHARMACOLOGICA SINICA (2021)

Review Medicine, Research & Experimental

Nanotechnology-based drug delivery for central nervous system disorders

Thuy Trang Nguyen et al.

Summary: Nanotechnology-based drug delivery platforms offer potential therapeutic approach for CNS disorders, but face challenges during clinical translation.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Environmental Sciences

Exercise Dosage in Reducing the Risk of Dementia Development: Mode, Duration, and Intensity-A Narrative Review

Sukai Wang et al.

Summary: Senile dementia, also known as dementia, is a mental deterioration linked to aging, primarily caused by Alzheimer's disease and multiple infarct dementia. Women have a higher risk of developing dementia compared to men. Physical exercise has been proven to be an effective way to reduce the risk of developing senile dementia.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Review Neurosciences

Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis

Alexandra C. M. Van Harten et al.

Summary: ALS, the most common adult-onset paralytic disorder, is characterized by the loss of motor neurons in the CNS. Recent research has shown that non-neuronal cells, particularly glial cells like astrocytes, play a role in the degeneration of motor neurons in ALS, potentially changing our understanding of the disease and treatment options.

TRENDS IN NEUROSCIENCES (2021)

Review Neurosciences

Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

Francesco Girolamo et al.

Summary: The text discusses the key role of pericytes in the neurovascular unit, emphasizing their unique characteristics and functions in brain microvessels. The heterogeneity of pericytes is primarily determined by their location and ontogeny, with understanding of different subtypes supporting the comprehension of specific interactions and mechanisms involved in normal and pathological angiogenesis.

FLUIDS AND BARRIERS OF THE CNS (2021)

Article Biochemistry & Molecular Biology

Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals

Mihaly Kozma et al.

Summary: Cells in the neurovascular unit actively participate in neuroinflammatory reactions by upregulating cell adhesion molecules and secreting proinflammatory cytokines. Both pericytes and endothelial cells can activate inflammasomes, with the noncanonical pathway being demonstrated in both types of cells. This activation leads to increased secretion of interleukin-1 beta and disruption of tight junctions. Overall, mutual activation of pericytes and endothelial cells occurs in inflammation, with inflammatory responses and barrier properties being affected.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Amyloid-β Pathway in Alzheimer's Disease

Harald Hampel et al.

Summary: Breakthroughs in molecular medicine have highlighted the significance of the amyloid-beta pathway in the pathophysiology of Alzheimer's disease. Established biochemical alterations of the A beta cycle serve as promising targets for the development of disease-modifying therapies. Research indicates a crucial role of A beta pathway dyshomeostasis in the dynamics of AD pathophysiology, supporting the development of A beta-targeting therapeutic strategies for early treatment of AD.

MOLECULAR PSYCHIATRY (2021)

Review Biochemistry & Molecular Biology

Multifaceted Alzheimer's Disease: Building a Roadmap for Advancement of Novel Therapies

Dapinder Kaur et al.

Summary: Alzheimer's disease is a common neurodegenerative disorder in elderly people, with cognitive impairment, characterized by extracellular Ass plaques and intracellular NFTs. Current research on AD focuses on Ass aggregation, tau hyperphosphorylation, impaired cholinergic signaling, neuroinflammation, and autophagy, but no single theory can fully describe the pathophysiological changes in AD.

NEUROCHEMICAL RESEARCH (2021)

Review Neurosciences

Neurotrophic Factors in Parkinson's Disease: Clinical Trials, Open Challenges and Nanoparticle-Mediated Delivery to the Brain

Olesja Bondarenko et al.

Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Nutrition & Dietetics

The Potential Roles of Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis

Shannon Morgan McCabe et al.

Summary: Manganese is an essential trace nutrient for life, but can become neurotoxic at high concentrations in the brain. The brain consists of two barriers - the blood-brain barrier (BBB) formed by endothelial cells and the blood-CSF barrier (BCB) formed by the choroid plexus - that prevent substances in the systemic circulation from reaching the brain and spinal cord. Studies have provided insights into manganese transport and metabolism in the brain, with a focus on the roles of the BBB and BCB in maintaining brain manganese homeostasis.

NUTRIENTS (2021)

Article Medicine, Research & Experimental

Age-associated changes in microglia and astrocytes ameliorate blood-brain barrier dysfunction

Jie Pan et al.

Summary: Research has found that BBB permeability to peripheral cells is significantly enhanced in aged mice, with microglia showing marked alterations in the negative regulation of protein phosphorylation and phagocytic vesicles, and astrocytes exhibiting elevated enzyme or peptidase-inhibitor activity in BBB function recovery.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Biochemistry & Molecular Biology

The Neuroinflammatory Role of Pericytes in Epilepsy

Gaku Yamanaka et al.

Summary: Pericytes are crucial for maintaining the integrity of the blood-brain barrier and have been implicated in neuroinflammation associated with epilepsy. Clinical and experimental studies have shown that pericytes undergo morphological changes and redistribution in response to proinflammatory cytokines, potentially contributing to epilepsy pathogenesis and BBB permeability. Furthermore, pericytes may act as sensors of the inflammatory response and have potential as a therapeutic target for seizure disorders.

BIOMEDICINES (2021)

Review Biochemistry & Molecular Biology

The role of extracellular vesicles in the physiological and pathological regulation of the blood-brain barrier

Sara Busatto et al.

Summary: Extracellular vesicles are biological nanoparticles secreted by cells that can transport bioactive substances, serving as both a potential source of diagnostic biomarkers and a promising class of nanovehicles for drug delivery. They play a crucial role in maintaining the blood-brain barrier under normal physiological and pathological conditions.

FASEB BIOADVANCES (2021)

Review Clinical Neurology

The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease

Immacolata Vecchio et al.

Summary: Alzheimer's disease is a chronic disabling disease that affects the central nervous system, leading to cognitive decline and language disorders. One of the causes of AD is the decrease of acetylcholine levels in the brain. Acetylcholinesterase inhibitors have been developed to counteract the progression of the disease, with drugs like donepezil and galantamine showing promising clinical benefits.

JOURNAL OF CENTRAL NERVOUS SYSTEM DISEASE (2021)

Review Biochemistry & Molecular Biology

Tight junctions and their regulation by non-coding RNAs

Xiaojiao Zhao et al.

Summary: Tight junction (TJ) is a zipping up junction structure located at the uppermost portion of adjacent epithelial/endothelial cells in organs and tissues, maintaining the stability of intracellular substances and functions. TJs are widely present in various organs and tissues, dysfunction of which can lead to various diseases, and they are also regulated by non-coding RNAs.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Bayesian inference for parameter estimation in lactoferrin-mediated iron transport across blood-brain barrier

Aminul Islam Khan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)

Review Biochemistry & Molecular Biology

Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells

Shyanne Page et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Article Materials Science, Multidisciplinary

Overcoming blood-brain barrier transport: Advances in nanoparticle-based drug delivery strategies

Shichao Ding et al.

MATERIALS TODAY (2020)

Review Immunology

Glial Cells: Role of the Immune Response in Ischemic Stroke

Shenbin Xu et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Neurosciences

Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance

Aditi Kandlur et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

Role of Insulin Resistance in the Alzheimer's Disease Progression

Thuy Trang Nguyen et al.

NEUROCHEMICAL RESEARCH (2020)

Article Clinical Neurology

Parkinson's disease: etiopathogenesis and treatment

Joseph Jankovic et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Review Immunology

Protective Functions of Reactive Astrocytes Following Central Nervous System Insult

Mathias Linnerbauer et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Medicine, Research & Experimental

Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development

Xiaobo Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Neurosciences

A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity

Hossam Kadry et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

Article Neurosciences

Brain health consequences of digital technology use

Gary W. Small et al.

DIALOGUES IN CLINICAL NEUROSCIENCE (2020)

Article Clinical Neurology

Effect of Mental Health Problems on the Quality of Life in Children with Lupus Nephritis

Azwin Mengindra Putera et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2020)

Review Immunology

Blood-brain barrier permeability and physical exercise

Marta A. Malkiewicz et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Review Biochemistry & Molecular Biology

Age-Associated Changes in the Immune System and Blood-Brain Barrier Functions

Michelle A. Erickson et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies

Stephanie Andrade et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Pharmacology & Pharmacy

Cell death assays for neurodegenerative disease drug discovery

Jeremy W. Linsley et al.

EXPERT OPINION ON DRUG DISCOVERY (2019)

Review Biochemistry & Molecular Biology

Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions

Maria Elena Gomez-Gomez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Neurosciences

Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases

Cameron Wells et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Review Neurosciences

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

Luke McAlary et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Health Care Sciences & Services

Clinical Evidence Supporting Early Treatment Of Patients With Spinal Muscular Atrophy: Current Perspectives

Tamara Dangouloff et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2019)

Article Clinical Neurology

2019 Alzheimer's disease facts and figures

Joseph Gaugler et al.

ALZHEIMERS & DEMENTIA (2019)

Review Biochemistry & Molecular Biology

Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease

Fatma Haddad et al.

MOLECULES (2018)

Review Clinical Neurology

Functional morphology of the blood-brain barrier in health and disease

Stefan Liebner et al.

ACTA NEUROPATHOLOGICA (2018)

Editorial Material Neurosciences

Huntington's disease: From basic science to therapeutics

Carlos Cepeda et al.

CNS NEUROSCIENCE & THERAPEUTICS (2018)

Review Neurosciences

Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms

Ying Yang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Neurosciences

Gene Therapy for Parkinson's Disease, An Update

Tobias M. Axelsen et al.

JOURNAL OF PARKINSONS DISEASE (2018)

Article Biochemistry & Molecular Biology

Quantification of kinetic rate constants for transcytosis of polymeric nanoparticle through blood-brain barrier

Aminul Islam Khan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Review Neurosciences

Converging pathways in neurodegeneration, from genetics to mechanisms

Li Ga et al.

NATURE NEUROSCIENCE (2018)

Review Geriatrics & Gerontology

Dysfunction of Cerebrovascular Endothelial Cells: Prelude to Vascular Dementia

Feixue Wang et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Environmental Sciences

Developmental neurotoxicity of succeeding generations of insecticides

Yael Abreu-Villaca et al.

ENVIRONMENT INTERNATIONAL (2017)

Review Neurosciences

Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease

Eric Tonnies et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Immunology

Alzheimer's disease: A matter of blood-brain barrier dysfunction?

Axel Montagne et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Endocrinology & Metabolism

Alzheimer's disease: Innate immunity gone awry?

Theodore B. VanItallie

METABOLISM-CLINICAL AND EXPERIMENTAL (2017)

Review Neurosciences

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kassandra Kisler et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Review Neurosciences

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

Panchanan Maiti et al.

TRANSLATIONAL NEURODEGENERATION (2017)

Review Anatomy & Morphology

Human astrocytes: structure and functions in the healthy brain

Flora Vasile et al.

BRAIN STRUCTURE & FUNCTION (2017)

Review Neurosciences

Corticostriatal Dysfunction in Huntington's Disease: The Basics

Kendra D. Bunner et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2016)

Review Neurosciences

Pericytes of the neurovascular unit: key functions and signaling pathways

Melanie D. Sweeney et al.

NATURE NEUROSCIENCE (2016)

Review Immunology

Astrocytes: Key Regulators of Neuroinflammation

Emanuela Colombo et al.

TRENDS IN IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

Matthew P. Parsons et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine

Bryant C. Nelson et al.

ANTIOXIDANTS (2016)

Review Medicine, Research & Experimental

Tight junction modulation of the blood brain barrier: CNS delivery of small molecules

Chris Greene et al.

TISSUE BARRIERS (2016)

Review Biochemistry & Molecular Biology

Establishment and Dysfunction of the Blood-Brain Barrier

Zhen Zhao et al.

Review Endocrinology & Metabolism

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease

Melanie D. Sweeney et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Cell Biology

Astrocyte Regulation of Blood Flow in the Brain

Brian A. MacVicar et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Cell Biology

The Blood-Brain Barrier

Richard Daneman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Letter Psychology, Clinical

Mental illness in Saudi Arabia: an overview

Adel F. Almutairi

PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT (2015)

Review Pharmacology & Pharmacy

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

Joana Bicker et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Review Clinical Neurology

The global prevalence of dementia: A systematic review and metaanalysis

Martin Prince et al.

ALZHEIMERS & DEMENTIA (2013)

Review Biochemistry & Molecular Biology

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

Daniele Del Rio et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Editorial Material Medicine, Research & Experimental

Drug Delivery across the Blood-Brain Barrier

Leslie A. Khawli et al.

MOLECULAR PHARMACEUTICS (2013)

Review Health Care Sciences & Services

Quality of life of people with mental health problems: a synthesis of qualitative research

Janice Connell et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2012)

Review Endocrinology & Metabolism

Neurological diseases in relation to the blood-brain barrier

Gary A. Rosenberg

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Review Medicine, Research & Experimental

Innate immunity in the central nervous system

Richard M. Ransohoff et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Multidisciplinary Sciences

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Paige E. Cramer et al.

SCIENCE (2012)

Review Neurosciences

Pharmacological Therapy in Parkinson's Disease: Focus on Neuroprotection

Zsigmond Tamas Kincses et al.

CNS NEUROSCIENCE & THERAPEUTICS (2011)

Review Pharmacology & Pharmacy

New non-oral drug delivery systems for Parkinson's disease treatment

Shadab Md et al.

EXPERT OPINION ON DRUG DELIVERY (2011)

Review Oncology

Temozolomide in malignant gliomas: current use and future targets

J. Lee Villano et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

Methionine in proteins defends against oxidative stress

Shen Luo et al.

FASEB JOURNAL (2009)

Review Biochemistry & Molecular Biology

Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging

Elizabeth Head

NEUROCHEMICAL RESEARCH (2009)

Article Neurosciences

Tissue Plasminogen Activator (tPA) and Matrix Metalloproteinases in the Pathogenesis of Stroke: Therapeutic Strategies

Rao Muralikrishna Adibhatla et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2008)

Review Neurosciences

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Uwe-Karsten Hanisch et al.

NATURE NEUROSCIENCE (2007)

Review Biotechnology & Applied Microbiology

Modelling of the blood-brain barrier in drug discovery and development

Romeo Cecchelli et al.

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Biotechnology & Applied Microbiology

Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes

Chun-Fang Xia et al.

JOURNAL OF GENE MEDICINE (2007)

Article Clinical Neurology

Small molecule neurotrophin receptor ligands: Novel strategies for targeting Alzheimer's disease mechanisms

Frank M. Longo et al.

CURRENT ALZHEIMER RESEARCH (2007)

Review Immunology

Astrocytes are active players in cerebral innate immunity

Cinthia Farina et al.

TRENDS IN IMMUNOLOGY (2007)

Article Chemistry, Multidisciplinary

Nanoparticle-mediated local and remote manipulation of protein aggregation

MJ Kogan et al.

NANO LETTERS (2006)

Review Neurosciences

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

Piera Pasinelli et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Article Immunology

Mitoxantrone induces cell death in peripheral blood leucocytes of multiple sclerosis patients

A Chan et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2005)

Review Multidisciplinary Sciences

Biomedicine - Toxic proteins in neurodegenerative disease

JP Taylor et al.

SCIENCE (2002)

Article Multidisciplinary Sciences

CA1-specific N-methyl-D-aspartate receptor knockout mice are deficient in solving a nonspatial transverse patterning task

L Rondi-Reig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)