Mitochondrial Aging and Senolytic Natural Products with Protective Potential

Living organisms do not disregard the laws of thermodynamics and must therefore consume energy for their survival. In this way, cellular energy exchanges, which aim above all at the production of ATP, a fundamental molecule used by the cell for its metabolisms, favor the formation of waste products that, if not properly disposed of, can contribute to cellular aging and damage. Numerous genes have been linked to aging, with some favoring it (gerontogenes) and others blocking it (longevity pathways). Animal model studies have shown that calorie restriction (CR) may promote longevity pathways, but given the difficult application of CR in humans, research is investigating the use of CR-mimetic substances capable of producing the same effect. These include some phytonutrients such as oleuropein, hydroxytyrosol, epigallo-catechin-gallate, fisetin, quercetin, and curcumin and minerals such as magnesium and selenium. Some of them also have senolytic effects, which promote the apoptosis of defective cells that accumulate over the years (senescent cells) and disrupt normal metabolism. In this article, we review the properties of these natural elements that can promote a longer and healthier life.

Automated summary

Living organisms need to consume energy for survival. Cellular energy exchanges produce waste products that can contribute to cellular aging and damage if not properly disposed of. Many genes are associated with aging, with some promoting it and others blocking it. Calorie restriction has been found to promote longevity pathways, and research is exploring CR-mimetic substances that can have the same effect. Certain phytonutrients and minerals have been found to promote a longer and healthier life.