Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer

Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory properties provide unique opportunities to control the innate immune system and inflammation. Here, we review the role of flavones in chronic inflammation with an emphasis on their impact on the molecular mechanisms underlying inflammatory diseases including obesity and cancer. Flavones can influence the innate immune cell repertoire restoring the immune landscape. Flavones impinge on NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways reestablishing immune homeostasis. Devoid of adverse side effects, flavones could present alternative opportunities for the treatment and prevention of chronic inflammation that contributes to obesity and cancer.

Automated summary

Flavones, natural phytochemicals found in our diet, possess anti-inflammatory properties that can effectively control the innate immune system and inflammation. They play a significant role in chronic inflammation, particularly in obesity and cancer, by influencing molecular mechanisms. Flavones restore immune landscape by impacting innate immune cell repertoire and reestablish immune homeostasis through NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways. With no adverse side effects, flavones could be alternative opportunities for treating and preventing chronic inflammation associated with obesity and cancer.