Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms24021081
Keywords
Dupuytren's contracture; sweat gland; CTGF; E-cadherin; epithelial-mesenchymal transition; extracellular matrix
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This study investigated the role of sweat glands in the pathogenesis of Dupuytren's contracture (DC) through proteomic analysis and immunofluorescence microscopy. The researchers found that a fraction of sweat gland epithelium underwent epithelial-mesenchymal transition, and increased connective tissue growth factor expression in DC sweat glands had both autocrine and paracrine effects in sustaining DC formation and inducing pathological changes in DC-associated sweat glands.
Dupuytren's contracture (DC) is a chronic and progressive fibroproliferative disorder restricted to the palmar fascia of the hands. Previously, we discovered the presence of high levels of connective tissue growth factor in sweat glands in the vicinity of DC nodules and hypothesized that sweat glands have an important role in the formation of DC lesions. Here, we shed light on the role of sweat glands in the DC pathogenesis by proteomic analysis and immunofluorescence microscopy. We demonstrated that a fraction of sweat gland epithelium underwent epithelial-mesenchymal transition illustrated by negative regulation of E-cadherin. We hypothesized that the increase in connective tissue growth factor expression in DC sweat glands has both autocrine and paracrine effects in sustaining the DC formation and inducing pathological changes in DC-associated sweat glands.
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