4.7 Article

Gsk-3-Mediated Proteasomal Degradation of ATF4 Is a Proapoptotic Mechanism in Mouse Pancreatic beta-Cells

Related references

Note: Only part of the references are listed.
Article Oncology

CK1δ stimulates ubiquitination-dependent proteasomal degradation of ATF4 to promote chemoresistance in gastric Cancer

Lifeng Feng et al.

Summary: Chemoresistance, previously seen as a stable outcome resulting from genetic changes, can also be unstable and reversible due to non-genetic alterations. The downregulation of ATF4 protein expression is associated with chemoresistance in gastric cancer cells, and its stabilization through inhibition of degradation can overcome resistance. ATF4 expression plays a crucial role in dynamic drug resistance, and interventions targeting its degradation pathway show promise in overcoming chemoresistance.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Endocrinology & Metabolism

ATF4-mediated transcriptional regulation protects against -cell loss during endoplasmic reticulum stress in a mouse model

Keisuke Kitakaze et al.

Summary: Transcriptional regulation by ATF4 maintains β-cell identity via ISR modulation, providing a promising target for the treatment of diabetes.

MOLECULAR METABOLISM (2021)

Review Cell Biology

Mechanisms, regulation and functions of the unfolded protein response

Claudio Hetz et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Immunology

Regulation of cellular immunity by activating transcription factor 4

Debasmita Mukherjee et al.

IMMUNOLOGY LETTERS (2020)

Review Multidisciplinary Sciences

The integrated stress response: From mechanism to disease

Mauro Costa-Mattioli et al.

SCIENCE (2020)

Article Chemistry, Medicinal

Molecular docking studies of salubrinal and its analogs as inhibitors of the GADD34:PP1 enzyme

Pavlo Zadorozhnii et al.

ADMET AND DMPK (2019)

Article Pharmacology & Pharmacy

A partnership with the proteasome; the destructive nature of GSK3

Holly Robertson et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

The integrated stress response

Karolina Pakos-Zebrucka et al.

EMBO REPORTS (2016)

Article Multidisciplinary Sciences

Crystal structure of eukaryotic translation initiation factor 2B

Kazuhiro Kashiwagi et al.

NATURE (2016)

Article Cell Biology

Regulation of ER stress-induced autophagy by GSK3β-TIP60-ULK1 pathway

Tiejian Nie et al.

CELL DEATH & DISEASE (2016)

Review Pharmacology & Pharmacy

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

Eleonore Beurel et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Multidisciplinary Sciences

Islet β cell mass in diabetes and how it relates to function, birth, and death

Gordon C. Weir et al.

YEAR IN DIABETES AND OBESITY (2013)

Article Multidisciplinary Sciences

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Shu-Yong Lin et al.

SCIENCE (2012)

Article Medicine, General & Internal

Type 2 diabetes across generations: from pathophysiology to prevention and management

Christopher J. Nolan et al.

LANCET (2011)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

Goekhan S. Hotamisligil

Review Endocrinology & Metabolism

The role for endoplasmic reticulum stress in diabetes mellitus

Decio L. Eizirik et al.

ENDOCRINE REVIEWS (2008)

Review Endocrinology & Metabolism

Glucolipotoxicity:: Fuel excess and β-cell dysfunction

Vincent Poitout et al.

ENDOCRINE REVIEWS (2008)

Article Biochemistry & Molecular Biology

Genetic deficiency of glycogen synthase kinase-3β corrects diabetes in mouse models of insulin resistance

Katsuya Tanabe et al.

PLOS BIOLOGY (2008)

Review Biochemistry & Molecular Biology

Translational control and the unfolded protein response

Ronald C. Wek et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Review Biochemistry & Molecular Biology

Endoplasmic reticulum stress signaling in pancreatic β-cells

Sonya G. Fonseca et al.

ANTIOXIDANTS & REDOX SIGNALING (2007)

Article Endocrinology & Metabolism

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

D. R. Laybutt et al.

DIABETOLOGIA (2007)

Review Medicine, Research & Experimental

Islet β cell failure in type 2 diabetes

Marc Prentki et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Biochemical Research Methods

Phosphate-binding tag, a new tool to visualize phosphorylated proteins

E Kinoshita et al.

MOLECULAR & CELLULAR PROTEOMICS (2006)

Article Endocrinology & Metabolism

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activation

K Ueda et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2005)

Review Biotechnology & Applied Microbiology

ER stress and the unfolded protein response

M Schröder et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)

Article Multidisciplinary Sciences

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

KM Vattem et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

HP Harding et al.

MOLECULAR CELL (2003)

Article Endocrinology & Metabolism

beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

AE Butler et al.

DIABETES (2003)

Article Biochemistry & Molecular Biology

Regulation of angiogenesis by glycogen synthase kinase-3β

HS Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

ATF4 degradation relies on a phosphorylation-dependent interaction with the SCFβTrCP ubiquitin ligase

I Lassot et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Regulated translation initiation controls stress-induced gene expression in mammalian cells

HP Harding et al.

MOLECULAR CELL (2000)