Correlation between Adrenoceptor Expression and Clinical Parameters in Degenerated Lumbar Intervertebral Discs

Despite advanced knowledge of the cellular and biomechanical processes of intervertebral disc degeneration (IVDD), the trigger and underlying mechanisms remain unclear. Since the sympathetic nervous system (SNS) has been shown to exhibit catabolic effects in osteoarthritis pathogenesis, it is attractive to speculate that it also influences IVDD. Therefore, we explored the adrenoceptor (AR) expression profile in human IVDs and correlated it with clinical parameters of patients. IVD samples were collected from n = 43 patients undergoing lumbar spinal fusion surgery. AR gene expression was analyzed by semi-quantitative polymerase chain reaction. Clinical parameters as well as radiological Pfirrmann and Modic classification were collected and correlated with AR expression levels. In total human IVD homogenates alpha 1A-, alpha 1B-, alpha 2A-, alpha 2B-, alpha 2C-, beta 1- and beta 2-AR genes were expressed. Expression of alpha 1A- (r = 0.439), alpha 2A- (r = 0.346) and beta 2-AR (r = 0.409) showed a positive and significant correlation with Pfirrmann grade. alpha 1A-AR expression was significantly decreased in IVD tissue of patients with adjacent segment disease (p = 0.041). The results of this study indicate that a relationship between IVDD and AR expression exists. Thus, the SNS and its neurotransmitters might play a role in IVDD pathogenesis. The knowledge of differential AR expression in different etiologies could contribute to the development of new therapeutic approaches for IVDD.

Automated summary

This study found that there is a correlation between the expression of adrenoceptors and intervertebral disc degeneration (IVDD) in human intervertebral discs, with certain receptors showing a positive correlation with Pfirrmann grade, indicating a potential role of the sympathetic nervous system in the pathogenesis of IVDD.