4.7 Article

Spatial Transcriptome Profiling of Mouse Hippocampal Single Cell Microzone in Parkinson's Disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation

Ina Huppertz et al.

Summary: The study reveals acetylation-driven riboregulation of ENO1 as a physiological mechanism of glycolytic control and stem cell differentiation regulation, providing new insights into the differentiation of stem cell metabolism and fate trajectories.

MOLECULAR CELL (2022)

Article Biotechnology & Applied Microbiology

Optimization of library preparation based on SMART for ultralow RNA-seq in mice brain tissues

Erteng Jia et al.

Summary: The article introduces a highly sensitive library construction protocol for ultralow input RNA sequencing, which successfully enhances the detection of low abundance genes and sensitivity, demonstrated in single-cell sequencing.

BMC GENOMICS (2021)

Article Biochemistry & Molecular Biology

Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns

Emilia Lekholm et al.

Summary: The study investigated gene expression of SV2A, SV2B and SV2C in two human neuroblastoma cell lines after differentiation, showing that different treatments affect different SV2 isoforms. Synergistic expression patterns between SV2B and CHAT, as well as SV2C and DAT, were observed, providing insights into the regulation of SV2 in neuronal cells.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

Review Biochemistry & Molecular Biology

Single-Cell RNA Sequencing in Parkinson's Disease

Shi-Xun Ma et al.

Summary: Single-cell and single-nucleus RNA sequencing technologies have advanced the molecular pathogenesis research of neurodegenerative disorders, particularly Parkinson's disease. Despite technical challenges in PD, recent studies have successfully characterized diverse cell-type populations and identified cell type-specific disease associations in PD.

BIOMEDICINES (2021)

Article Cell Biology

Single-nucleus transcriptomic landscape of primate hippocampal aging

Hui Zhang et al.

Summary: A systematic study of aging effects on primate hippocampal cells revealed new aging-associated phenotypic changes such as DNA damage, heterochromatin erosion, loss of proteostasis, and elevated inflammation. Neural transiently amplifying progenitor cells and microglia were identified as the most affected cell types by aging. Analysis of gene-expression dynamics showed impaired cell division and compromised neuronal function in aging, along with elevated pro-inflammatory responses in aged microglia.

PROTEIN & CELL (2021)

Article Neurosciences

Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease

Julio Aguila et al.

Summary: This study identified transcriptomes and differentially expressed genes (DEGs) of human substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) dopamine neurons, revealing unique gene interactions and regulation differences between the subpopulations. Analysis of Parkinson's Disease tissues showed potential biomarkers, such as down-regulated SNc markers SLIT1 and ATP2A3, distinguishing SNc and VTA dopamine neurons. These findings provide insights into modulating dopamine neuron resilience and validating cell identity of stem cell-derived dopamine neurons.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Article Clinical Neurology

Association Analyses of SNAP25, HNMT, FCHSD1, and DBH Single-Nucleotide Polymorphisms with Parkinson's Disease in a Northern Chinese Population

Cuiyun Dai et al.

Summary: Genetic distribution analysis in a northern Chinese population revealed that the mutant-allele T in FCHSD1 rs456998 may have a protective role in reducing the risk of Parkinson's disease. Further studies are needed to confirm these findings.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

Review Neurosciences

The Effects of General Anesthetics on Synaptic Transmission

Xuechao Hao et al.

CURRENT NEUROPHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate

Wei Qin et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Neuroimaging

Hippocampal CA1 subfield predicts episodic memory impairment in Parkinson's disease

Christian La et al.

NEUROIMAGE-CLINICAL (2019)

Review Biochemistry & Molecular Biology

Neuronal calcium signaling: function and dysfunction

Marisa Brini et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Article Biochemistry & Molecular Biology

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

Hye Jin Yun et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2013)

Article Medicine, Research & Experimental

Physiological Phenotype and Vulnerability in Parkinson's Disease

D. James Surmeier et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Neurosciences

Adult hippocampal neurogenesis and its role in Alzheimer's disease

Yangling Mu et al.

MOLECULAR NEURODEGENERATION (2011)

Review Clinical Neurology

Parkinson's Disease: The Quintessential Neuropsychiatric Disorder

Daniel Weintraub et al.

MOVEMENT DISORDERS (2011)

Review Neurosciences

Striatum-hippocampus balance: From physiological behavior to interneuronal pathology

Veronica Ghiglieri et al.

PROGRESS IN NEUROBIOLOGY (2011)

Review Neurosciences

NeuroD6 Genomic Signature Bridging Neuronal Differentiation to Survival Via the Molecular Chaperone Network

Martine Uittenbogaard et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2010)

Article Clinical Neurology

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

Mariese A. Hely et al.

MOVEMENT DISORDERS (2008)

Article Multidisciplinary Sciences

Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans

Mathias Pessiglione et al.

NATURE (2006)

Review Geriatrics & Gerontology

Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)