4.7 Review

Oxidative Stress and Immune Response in Melanoma: Ion Channels as Targets of Therapy

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Adaptation to oxidative stress at cellular and tissue level

Rachid Akki et al.

Summary: Studies have shown that cells and tissues may enhance their resistance to more severe ischaemic injuries by undergoing ischemic preconditioning under low oxidative stress conditions. This review summarizes the latest knowledge on adaptive mechanisms, signaling transduction pathways, antioxidant systems, and in vivo adaptation strategies in response to ischemia/reperfusion and brain trauma events.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2022)

Review Physiology

Role of SLC4 and SLC26 solute carriers during oxidative stress

Alessia Remigante et al.

Summary: Bicarbonate, a major anion in mammalian tissues and fluids, plays a critical role in cell and systemic pH homeostasis and is involved in transporting ions and substrates across cell membranes. Chloride/bicarbonate exchangers, abundant in erythrocytes and epithelial cells, are particularly susceptible to oxidative stress. This review focuses on the physiological functions and pathophysiological changes of Cl-/HCO3- exchangers belonging to the SLC4 and SLC26 superfamilies in relation to oxidative stress.

ACTA PHYSIOLOGICA (2022)

Article Pharmacology & Pharmacy

The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca2+ in melanoma and pancreatic duct adenocarcinoma cell lines

Paolo Zuccolini et al.

Summary: This research investigated the effect of DCPIB on pancreatic duct adenocarcinoma (PDAC) and melanoma and found that DCPIB directly targeted BK channels and increased intracellular Ca2+ levels. These findings are important for the development of DCPIB-based modulators of ion channels and membrane proteins in the future.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

The Role of Calcium Signaling in Melanoma

Haoran Zhang et al.

Summary: Calcium signaling plays crucial roles in the development and progression of cutaneous melanoma. It affects melanogenesis, the tumor microenvironment, and can be targeted for therapeutic intervention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell Biology

D-Galactose induced early aging in human erythrocytes: Role of band 3 protein

Alessia Remigante et al.

Summary: The study found that utilizing D-Gal can mimic early aging in human erythrocytes, assessing B3p ion transport function is a sensitive tool to monitor aging development, and D-Gal leads to Hb glycation and substantial changes in the endogenous antioxidant system. Aging impacts B3p function through stages involving Hb glycation first and then oxidative events at the membrane level.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Article Cell Biology

Inflammasome involvement in CS-induced damage in HaCaT keratinocytes

Roxane Prieux et al.

Summary: Cigarette smoke can negatively impact skin and lung tissues, increasing susceptibility to infections and diseases. The inflammasome plays a crucial role in pollution exposure, being associated with various skin conditions.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2022)

Article Dermatology

Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040

Melina Arnold et al.

Summary: Despite preventable cases, cutaneous melanoma remains the most serious skin cancer worldwide. Understanding the scale and profile of the disease is crucial to focus and strengthen global prevention efforts. The study reveals that melanoma is more frequent among males and is estimated to significantly increase by 2040 if current rates continue.

JAMA DERMATOLOGY (2022)

Article Cell Biology

Oxidative Stress Differentially Influences the Survival and Metabolism of Cells in the Melanoma Microenvironment

Emily R. Trzeciak et al.

Summary: The cellular composition of the tumor microenvironment has a significant impact on responses to cancer therapies. This study analyzes the effects of oxidative stress induced by cold atmospheric plasma (CAP) on tumor cells, T cells, and macrophages in melanoma microenvironment. The study found that CAP treatment reduced viability and proliferation of cells, induced cell cycle arrest and apoptosis, and increased mitochondrial stress. CAP treatment also influenced the polarization of macrophages and inhibited the growth of melanoma cells in vitro.

CELLS (2022)

Review Biochemistry & Molecular Biology

The Double-Edged Sword of Oxidative Stress in Skin Damage and Melanoma: From Physiopathology to Therapeutical Approaches

Monica Emanuelli et al.

Summary: The skin is constantly exposed to reactive oxygen species (ROS) and oxidative stress may play a role in skin diseases, including melanoma. Melanocytes are more susceptible to oxidative stress due to their melanin production process.

ANTIOXIDANTS (2022)

Editorial Material Biochemistry & Molecular Biology

Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases

Alessia Remigante et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Oxidation Stress as a Mechanism of Aging in Human Erythrocytes: Protective Effect of Quercetin

Alessia Remigante et al.

Summary: This study aimed to verify the protective role of Quercetin in a d-Galactose-induced model of aging in human erythrocytes. It was found that Quercetin preferentially improved lipid peroxidation rather than protein oxidation and prevented glycated hemoglobin formation. These findings suggest that the Band 3 protein could be a potential target for antioxidant treatments against aging-related disturbances.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Oncology

Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma

Alessandra Pecorelli et al.

Summary: UV radiation is a crucial risk factor for melanoma, influencing DNA damage, oxidative stress, and miRNA dysregulation, which play important roles in melanomagenesis. Genetic mutations and other factors are involved in the transformation of melanocytes to malignant melanoma, with UV radiation playing a prominent role.

CANCERS (2022)

Editorial Material Cell Biology

Editorial: Ion transporters and channels in cellular pathophysiology

Alessia Remigante et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Chemistry, Multidisciplinary

UVA Radiation, DNA Damage, and Melanoma

Seung-Gi Jin et al.

Summary: Melanoma, a lethal skin tumor, is linked to sunlight exposure. UVB radiation plays a significant role in melanoma formation, while the potential role of UVA radiation needs further investigation.

ACS OMEGA (2022)

Review Medicine, General & Internal

Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications

Lishu Zhao et al.

Summary: Immunotherapy targeting checkpoints has revolutionized cancer therapy, with LAG-3 being a key inhibitory checkpoint that plays a role in anti-tumor immunity. Increasing evidence suggests the potential of LAG-3 blockade in enhancing immune efficacy.

CHINESE MEDICAL JOURNAL (2022)

Review Biochemistry & Molecular Biology

Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions

Katrin Pansy et al.

Summary: The TME plays a crucial role in regulating tumor growth and metastasis, with immune escape enabling tumor cells to maintain their proliferation. Novel immunotherapies have been successfully developed based on intensive study of the mechanisms involved in immune evasion, such as membrane-bound and soluble factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Editorial Material Cell Biology

STIM2: Redox-sensor and effector of the (tumor) microenvironment

Albrecht Schwab et al.

Summary: Ion channels and associated proteins act as a critical interface in cancer cells, sensing and transducing physical-chemical cues from the tumor microenvironment to shape cell behavior. In a recent study, Gibhardt et al. demonstrated how STIM2, a key component of the store-operated Ca2+ entry mechanism in melanoma cells, is regulated by redox signaling.

CELL CALCIUM (2021)

Article Peripheral Vascular Disease

The heterogeneity of cancer endothelium: The relevance of angiogenesis and endothelial progenitor cells in cancer microenvironment

Giovanna Armani et al.

Summary: Tumor-associated vessels formation is crucial for cancer growth and metastasis, involving complex interactions between tumor endothelium, immune response, and other components of the tumor microenvironment. The diversity of cancer endothelium, originating from various sources and exhibiting morphological and molecular aberrations, is recognized. Endothelial Progenitor Cells play an important role in tumor vasculature composition, providing physical support and paracrine signaling for angiogenesis. Various treatment options, particularly novel therapeutic strategies to overcome tumor resistance to anti-angiogenic agents, are being explored.

MICROVASCULAR RESEARCH (2021)

Article Oncology

Biology of Melanoma

Stephen M. Ostrowski et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2021)

Article Oncology

Exploration of the Prognostic and Immunotherapeutic Value of B and T Lymphocyte Attenuator in Skin Cutaneous Melanoma

Xubin Dong et al.

Summary: The study reveals that BTLA is upregulated in metastatic melanoma and correlated with patient prognosis, serving as an independent survival indicator. Furthermore, BTLA is positively associated with the infiltrating levels of different immune cells and the activity of the anti-cancer immunity cycle.

FRONTIERS IN ONCOLOGY (2021)

Review Physiology

Hypoxic Regulation of the Large-Conductance, Calcium and Voltage-Activated Potassium Channel, BK

Sara V. Ochoa et al.

Summary: Hypoxia is characterized by reduced cellular oxygen levels, triggering cell-signaling cascades, oxidative stress, activation of pro-inflammatory molecules, and influencing various cardiovascular diseases. The BK channel plays a central role in oxygen sensing mechanisms, with modifications of its properties involved in physiological functions and response to hypoxia.

FRONTIERS IN PHYSIOLOGY (2021)

Article Oncology

NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines

Alessia Remigante et al.

Summary: The study investigated the effects of different BK channel activators in melanoma and pancreatic duct carcinoma cell lines, finding that only one activator had significant effects on cancer-associated processes, while also increasing intracellular Ca2+ concentration independently of BK channel activation. The activation of the BK channel alone was not sufficient to produce beneficial anti-cancer effects, and the use of specific BK channel openers as anti-cancer agents may have complications.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Oxidative Stress-Related Mechanisms in Melanoma and in the Acquired Resistance to Targeted Therapies

Stefania Pizzimenti et al.

Summary: Melanoma is a highly aggressive cancer with activating mutations in BRAF being the most common genetic alterations. Targeted inhibitors have improved survival rates in advanced melanoma patients, but resistance still develops in around 50% of patients within the first year of therapy, presenting a significant challenge in managing BRAF-mutated advanced melanoma. Understading the mechanisms of resistance, including genetic, epigenetic, and oxidative stress-related factors, is crucial in developing effective therapies.

ANTIOXIDANTS (2021)

Review Cell Biology

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis

Ayat S. Hammad et al.

Summary: Ca2+ signaling is crucial for cell migration, with a focus on the diverse functions of SOCE pathway. While SOCE has been implicated in regulating focal adhesion turnover, its role in other aspects of cell migration remains less well-defined and requires further research.

CELLS (2021)

Article Medicine, Research & Experimental

The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma

Mohammad Malekan et al.

Summary: The adaptation to O2 loss is regulated by hypoxia-inducible factors such as HIF-1 alpha, which plays a crucial role in melanoma progression through various signaling pathways. Therefore, HIF-1 alpha serves as a diagnostic/prognostic biomarker and a potential target for therapy in melanoma.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Biochemistry & Molecular Biology

Calcium signaling in cancer progression and therapy

Ling Wu et al.

Summary: The ancient Greek saying 'everything flows' is true for all living things, demonstrating the importance of calcium signaling in cellular activities. Recent research has highlighted the significant roles calcium signaling plays in cancer progression, prompting further exploration into its potential as a target for improving cancer therapies.

FEBS JOURNAL (2021)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?

Sharon Negri et al.

Summary: The intracellular Ca2+ concentration plays a significant role in endothelial cell functions, and both moderate and excessive amounts of ROS can regulate endothelial functions and lead to disorders.ROS-induced endothelial Ca2+ signals are crucial for vascular functions, but aberrant ROS generation can result in endothelial dysfunction and various diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase

Loretta Ferrera et al.

Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Effect of TRPM2-Mediated Calcium Signaling on Cell Proliferation and Apoptosis in Esophageal Squamous Cell Carcinoma

Xingbang Wang et al.

Summary: Research suggests that TRPM2 channel is associated with ESCC development and therapeutic response, 5-FU enhances TRPM2-mediated calcium signaling to reduce cell proliferation and increase apoptosis, potentially serving as a target for ESCC treatment.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Review Cell Biology

Ageing, age-related diseases and oxidative stress: What to do next?

Jiao Luo et al.

AGEING RESEARCH REVIEWS (2020)

Review Oncology

Tim-3 finds its place in the cancer immunotherapy landscape

Nandini Acharya et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Biochemistry & Molecular Biology

d-Galactose Decreases Anion Exchange Capability through Band 3 Protein in Human Erythrocytes

Alessia Remigante et al.

ANTIOXIDANTS (2020)

Article Biochemistry & Molecular Biology

Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 Channels

Andres Tittarelli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry

Christine Silvia Gibhardt et al.

CELL REPORTS (2020)

Review Biochemistry & Molecular Biology

Overcoming Immune Evasion in Melanoma

Kevinn Eddy et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

O-GlcNAcylation Suppresses the Ion Current IClswell by Preventing the Binding of the Protein ICln to α-Integrin

Roberta Costa et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Immunology

Reactive Oxygen Species: Drivers of Physiological and Pathological Processes

Javier Checa et al.

JOURNAL OF INFLAMMATION RESEARCH (2020)

Review Biochemistry & Molecular Biology

The Influence of Tumor Microenvironment on Immune Escape of Melanoma

Aleksandra Simiczyjew et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Susceptibility of erythrocytes from different sources to xenobiotics-induced lysis

Rosalia Crupi et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2019)

Review Cell Biology

TRPM2 in Cancer

Barbara A. Miller

CELL CALCIUM (2019)

Review Genetics & Heredity

The role of MiRNA in polycystic ovary syndrome (PCOS)

Baiqi Chen et al.

Review Immunology

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

Florian R. Greten et al.

IMMUNITY (2019)

Review Biochemistry & Molecular Biology

Nitric oxide and its derivatives in the cancer battlefield

Anna Kamm et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

Review Oncology

Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

Monica Marzagalli et al.

SEMINARS IN CANCER BIOLOGY (2019)

Review Nutrition & Dietetics

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

Thomas Senoner et al.

NUTRIENTS (2019)

Review Biochemistry & Molecular Biology

Oxidative stress and antioxidants in the pathophysiology of malignant melanoma

Elena Obrador et al.

BIOLOGICAL CHEMISTRY (2019)

Review Dermatology

Mechanisms and prevention of UV-induced melanoma

Ashley Sample et al.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2018)

Article Biochemistry & Molecular Biology

Neuronal-like differentiated SH-SY5Y cells adaptation to a mild and transient H2O2-induced oxidative stress

Rachid Akki et al.

CELL BIOCHEMISTRY AND FUNCTION (2018)

Article Oncology

Genetics of metastasis: melanoma and other cancers

Noel Turner et al.

CLINICAL & EXPERIMENTAL METASTASIS (2018)

Article Biochemistry & Molecular Biology

The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization

Pingli Mo et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2018)

Review Physiology

ION CHANNELS IN CANCER: ARE CANCER HALLMARKS ONCOCHANNELOPATHIES?

Natalia Prevarskaya et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Cell Biology

ROS signalling in the biology of cancer

Jennifer N. Moloney et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

Review Geriatrics & Gerontology

Oxidative stress, aging, and diseases

Ilaria Liguori et al.

CLINICAL INTERVENTIONS IN AGING (2018)

Review Biochemistry & Molecular Biology

Sunlight damage to cellular DNA: Focus on oxidatively generated lesions

Andre Passaglia Schuch et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Medicine, Research & Experimental

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

Robert Sackstein et al.

LABORATORY INVESTIGATION (2017)

Review Biochemistry & Molecular Biology

Oxidative Stress

Helmut Sies et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)

Article Dermatology

Melanoma: tumor microenvironment and new treatments

Mara Huffenbaecher Giavina-Bianchi et al.

ANAIS BRASILEIROS DE DERMATOLOGIA (2017)

Review Cell Biology

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

Long He et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

Review Neurosciences

The role of Orai-STIM calcium channels in melanocytes and melanoma

Hedwig Stanisz et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Review Cell Biology

Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment

Xinfeng Chen et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

Article Oncology

ULTRAVIOLET RADIATION EXPOSURE AND ITS IMPACT ON SKIN CANCER RISK

Meg Watson et al.

SEMINARS IN ONCOLOGY NURSING (2016)

Review Cell Biology

Calcium signaling and cell proliferation

Mauro Cunha Xavier Pinto et al.

CELLULAR SIGNALLING (2015)

Review Infectious Diseases

The immunology and inflammatory responses of human melanocytes in infectious diseases

Philippe Gasque et al.

JOURNAL OF INFECTION (2015)

Article

Melanocytes and Skin Immunity

Yuxiao Hong et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2015)

Review Cell Biology

Cellular Mechanisms of Oxidative Stress and Action in Melanoma

Mario Venza et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

Article Dermatology

Do inflammatory pathways drive melanomagenesis?

Samantha L. Schneider et al.

EXPERIMENTAL DERMATOLOGY (2015)

Review Oncology

EMT and tumor metastasis

Sarah Heerboth et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2015)

Review Pharmacology & Pharmacy

TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration

N. Nielsen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Review Neurosciences

Apoptosis and Oxidative Stress in Neurodegenerative Diseases

Elena Radi et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Article Medicine, Research & Experimental

Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy

Duane Moogk et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Review Oncology

Pheomelanin-induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma

Alessandra Napolitano et al.

PIGMENT CELL & MELANOMA RESEARCH (2014)

Review Biology

Ion channels in cancer: future perspectives and clinical potential

Florian Lang et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Review Cell Biology

Oxidative stress and cancer: An overview

Venus Sosa et al.

AGEING RESEARCH REVIEWS (2013)

Article Dermatology

ORAI1 Ca2+ Channels Control Endothelin-1-Induced Mitogenesis and Melanogenesis in Primary Human Melanocytes

Hedwig Stanisz et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

Article Physiology

Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species

Justin R. Papreck et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)

Article Cell Biology

Ion channels and tranporters in cancer. 2. Ion channels and the control of cancer cell migration

Vishnu Anand Cuddapah et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)

Review Oncology

Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy

R. Speeckaert et al.

PIGMENT CELL & MELANOMA RESEARCH (2011)

Review Biochemistry & Molecular Biology

Oxidative stress, inflammation, and cancer How are they linked?

Simone Reuter et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Review Biochemistry & Molecular Biology

Reactive oxygen species in cancer

Geou-Yarh Liou et al.

FREE RADICAL RESEARCH (2010)

Article Biochemistry & Molecular Biology

Factors altering the haemolytic power of crude venom from Aiptasia mutabilis (Anthozoa) nematocysts

A. Marino et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2009)

Editorial Material Dermatology

What are melanocytes really doing all day long...?

P. M. Plonka et al.

EXPERIMENTAL DERMATOLOGY (2009)

Article Dermatology

pH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function

Roshan Gunathilake et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

Review Cell Biology

Radical-free biology of oxidative stress

Dean P. Jones

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Review Oncology

Reactive oxygen species in melanoma and its therapeutic implications

Hanneke G. M. Wittgen et al.

MELANOMA RESEARCH (2007)

Review Biochemistry & Molecular Biology

Stromal responses in human primary melanoma of the skin

LCL van Kempen et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2005)

Review Cell Biology

Ion channels:: Function unravelled by dysfunction

TJ Jentsch et al.

NATURE CELL BIOLOGY (2004)

Article Cell Biology

Membrane thickness changes ion-selectivity of channel-proteins

M Garavaglia et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2004)

Review Biochemistry & Molecular Biology

The role of thioredoxin in the aging process: Involvement of oxidative stress

T Yoshida et al.

ANTIOXIDANTS & REDOX SIGNALING (2003)

Review Cell Biology

Calcium signalling: Dynamics, homeostasis and remodelling

MJ Berridge et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Review Multidisciplinary Sciences

Inflammation and cancer

LM Coussens et al.

NATURE (2002)

Review Cell Biology

Redox regulation in human melanocytes and melanoma

FL Meyskens et al.

PIGMENT CELL RESEARCH (2001)

Article Cell Biology

Synthetic melanin suppresses production of proinflammatory cytokines

N Mohagheghpour et al.

CELLULAR IMMUNOLOGY (2000)