4.7 Editorial Material

Research of Mitochondrial Function, Structure, Dynamics and Intracellular Organization

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles

Andrey V. V. Kuznetsov et al.

Summary: Analyzing the function, structure, and intracellular organization of mitochondria is crucial for understanding energy metabolism and transfer. Differences between in situ and in vitro observations of mitochondria necessitate careful interpretation of experimental and clinical data. Crosstalk between mitochondria and the cell environment plays a vital role in regulating metabolism and physiology. Therefore, analyzing mitochondria in their natural setting is important.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Synapses: The Brain's Energy-Demanding Sites

Andreia Faria-Pereira et al.

Summary: The brain is one of the most energy-consuming organs in the body, and synaptic transmission is a major contributor to this energy consumption. The brain primarily uses glucose for energy, which is metabolized through glycolysis and/or mitochondrial oxidative phosphorylation. This review examines the balance between glycolysis and oxidative phosphorylation in meeting synaptic energy demands. Dysregulation of synaptic bioenergetics is increasingly associated with neurodegenerative disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Puerarin-V Improve Mitochondrial Respiration and Cardiac Function in a Rat Model of Diabetic Cardiomyopathy via Inhibiting Pyroptosis Pathway through P2X7 Receptors

Shuchan Sun et al.

Summary: Puerarin-V has been shown to have beneficial effects on diabetic cardiomyopathy by improving cardiac function, suppressing inflammation, and inhibiting pyroptosis pathway. Compared to other drugs, puerarin-V demonstrates better outcomes in treating diabetic cardiomyopathy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism

Andrey Kuznetsov et al.

Summary: Mitochondria play a crucial role in energy production and participate in various cellular processes, including redox regulation, signal transduction, and cellular metabolism. They exhibit cell/tissue-specific functions and interact with other cellular components, influencing overall cell physiology.

ANTIOXIDANTS (2022)

Review Biochemistry & Molecular Biology

Mitochondrial Oxidative Stress-A Causative Factor and Therapeutic Target in Many Diseases

Pawel Kowalczyk et al.

Summary: Oxidative stress arises from excessive production of ROS and impairment of antioxidant defense systems, leading to damage to cellular biomolecules such as DNA and contributing to cellular damage and disease development. Research has highlighted the significant role of mitochondrial oxidative stress in a variety of pathological processes, from Alzheimer's disease to autoimmune type 1 diabetes, and explored therapeutic approaches targeting oxidative stress.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

From Forensics to Clinical Research: Expanding the Variant Calling Pipeline for the Precision ID mtDNA Whole Genome Panel

Filipe Cortes-Figueiredo et al.

Summary: Despite the various methods available for mtDNA sample preparation, sequencing, and data analysis, there is still a need for innovation compared to nDNA research. The Precision ID mtDNA Whole Genome Panel by Applied Biosystems is a novel library preparation kit suitable for degraded samples and low DNA input, however, its bioinformatic processing occurs in Ion Torrent Suite Software, producing BAM files aligned to an unorthodox version of rCRS with a heteroplasmy threshold of 10%. A customizable pipeline called PrecisionCallerPipeline (PCP) was presented in this study for processing samples correctly after Ion Torrent sequencing with the Precision ID library kit, achieving improved performance metrics compared to the proprietary software, with optimal performance at a 2.5% heteroplasmy threshold.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Ordered Clusters of the Complete Oxidative Phosphorylation System in Cardiac Mitochondria

Semen Nesterov et al.

Summary: The study revealed a new type of OXPHOS structural organization in rat heart mitochondria cristae during ATP synthesis, ensuring quickness, efficiency, and damage resistance of the system with direct proton transfer from pumps to ATP synthase along the lateral pH gradient without energy dissipation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2-Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages

Takayuki Marutani et al.

Summary: Mitocryptides are a novel family of endogenous neutrophil-activating peptides derived from various mitochondrial proteins. MCT-2, one of these peptides, specifically activates FPR2 and its minimum active structure is a N-terminal heptapeptide. The degradation of MCT-2 in serum generates MCT-2(1-4), which can activate FPR1 and promote delayed immune responses.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Hearing Impairment in a Mouse Model of Diabetes Is Associated with Mitochondrial Dysfunction, Synaptopathy, and Activation of the Intrinsic Apoptosis Pathway

Ah-Ra Lyu et al.

Summary: The research indicates that diabetic hearing loss is closely associated with synaptopathy, microangiopathy, damage to the mitochondrial structure and function, and activation of the intrinsic apoptosis pathway. Mitochondrial dysfunction plays a significant role in diabetic hearing loss.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Cell Biology

The multifaceted contributions of mitochondria to cellular metabolism

Jessica B. Spinelli et al.

NATURE CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle

Lilli Winter et al.

HUMAN MOLECULAR GENETICS (2015)

Article Cardiac & Cardiovascular Systems

Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells

Marcela Gonzalez-Granillo et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)

Article Biochemistry & Molecular Biology

Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species

Andreas Daiber

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Article Biochemistry & Molecular Biology

Survival signaling by C-RAF:: Mitochondrial reactive oxygen species and Ca2+ are critical targets

Andrey V. Kuznetsov et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Cell Biology

The apoptosome: signalling platform of cell death

Stefan J. Riedl et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Biochemistry & Molecular Biology

Mitochondria: More than just a powerhouse

Heidi M. McBride et al.

CURRENT BIOLOGY (2006)

Review Biochemistry & Molecular Biology

Mitochondria, oxidants, and aging

RS Balaban et al.

Review Neurosciences

Mitochondrial formation of reactive oxygen species

JF Turrens

JOURNAL OF PHYSIOLOGY-LONDON (2003)

Review Biochemistry & Molecular Biology

Mitochondria: Releasing power for life and unleashing the machineries of death

DD Newmeyer et al.

Review Biochemistry & Molecular Biology

Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic β-cells

P Maechler

CELLULAR AND MOLECULAR LIFE SCIENCES (2002)

Review Biochemistry & Molecular Biology

Mitochondrial control of cell death

G Kroemer et al.

NATURE MEDICINE (2000)