Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms24021037
Keywords
TRPC4; skin tumors; melanoma; squamous cell carcinoma; basal cell carcinoma
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TRPCs are important in tumor biology, particularly in Ca2+ homeostasis in cancer cells. TRPC4, a pH-sensitive protein, may function as a signaling molecule in the altered tumor microenvironment due to the reversed pH-gradient in solid tumors. The study investigated TRPC4 expression profiles in common skin cancers, revealing that SCC, NCN, and MM show positive TRPC4-expression, while BCC only does so in about half of the analyzed samples. This finding suggests TRPC4 as an immunohistochemical marker to distinguish SCC and BCC and warrants further research on its role in tumor progression and metastasis.
TRPCs (transient receptor potential classical or cation channels) play a crucial role in tumor biology, especially in the Ca2+ homeostasis in cancer cells. TRPC4 is a pH-sensitive member of this family of proteins. As solid tumors exhibit an inversed pH-gradient with lowered extracellular and increased intracellular pH, both contributing to tumor progression, TRPC4 might be a signaling molecule in the altered tumor microenvironment. This is the first study to investigate the expression profiles of TRPC4 in common skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM) and nevus cell nevi (NCN). We found that all SCCs, NCNs, and MMs show positive TRPC4-expression, while BCCs do only in about half of the analyzed samples. These data render TRPC4 an immunohistochemical marker to distinguish SCC and BCC, and this also gives rise to future studies investigating the role of TRPC4 in tumor progression, and especially metastasis as BCCs very rarely spread and are mostly negative for TRPC4.
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