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Extracellular Vesicles as Therapeutic Resources in the Clinical Environment

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review

Pengyu Hong et al.

STEM CELL RESEARCH & THERAPY (2019)

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Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

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ACTA BIOMATERIALIA (2019)

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MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway

Yongxiang Yang et al.

NEUROCHEMICAL RESEARCH (2019)

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Improved Loading of Plasma-Derived Extracellular Vesicles to Encapsulate Antitumor miRNAs

Margherita Alba Carlotta Pomatto et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

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Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size-exclusion chromatography: yield, purity and functional potential

Kaloyan Takov et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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In vitro decidualisation of human endometrial stromal cells is enhanced by seminal fluid extracellular vesicles

Helena Rodriguez-Caro et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Extracellular Vesicles Derived from Wharton's Jelly Mesenchymal Stem Cells Prevent and Resolve Programmed Cell Death Mediated by Perinatal Hypoxia-Ischemia in Neuronal Cells

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CELL TRANSPLANTATION (2018)

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Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis

Cosimo De Bari et al.

CURRENT OPINION IN PHARMACOLOGY (2018)

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Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Exosome isolation from distinct biofluids using precipitation and column-based approaches

Tania Soares Martins et al.

PLOS ONE (2018)

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Exosomes Derived from Hypoxia-Treated Human Adipose Mesenchymal Stem Cells Enhance Angiogenesis Through the PKA Signaling Pathway

Chunling Xue et al.

STEM CELLS AND DEVELOPMENT (2018)

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Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

Naohiro Seo et al.

NATURE COMMUNICATIONS (2018)

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A System of Cytokines Encapsulated in ExtraCellular Vesicles

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SCIENTIFIC REPORTS (2018)

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Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

Byong Seung Cho et al.

STEM CELL RESEARCH & THERAPY (2018)

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Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

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THERANOSTICS (2018)

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Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect

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STEM CELLS INTERNATIONAL (2018)

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Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems

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PHARMACEUTICS (2018)

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Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment

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BIOTECHNOLOGY ADVANCES (2018)

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Preservation of exosomes at room temperature using lyophilization

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

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Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation

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CELL REPORTS (2018)

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To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles

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FRONTIERS IN PHARMACOLOGY (2018)

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Tangential Flow Filtration for Highly Efficient Concentration of Extracellular Vesicles from Large Volumes of Fluid

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CELLS (2018)

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

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JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Generation and testing of clinical-grade exosomes for pancreatic cancer

Mayela Mendt et al.

JCI INSIGHT (2018)

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Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications

Anjana Jeyaram et al.

AAPS JOURNAL (2018)

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Exosomes: From Garbage Bins to Promising Therapeutic Targets

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

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MOLECULAR THERAPY (2017)

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Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar et al.

NATURE (2017)

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Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Effect of prolonged freezing of semen on exosome recovery and biologic activity

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SCIENTIFIC REPORTS (2017)

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Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

Ligia Lins de Castro et al.

STEM CELL RESEARCH & THERAPY (2017)

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Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

Agnes T. Reiner et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

Jialei Yang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

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Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

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SCIENTIFIC REPORTS (2017)

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Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling

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SCIENTIFIC REPORTS (2017)

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Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Rosario Maroto et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Effective isolation of exosomes with polyethylene glycol from cell culture supernatant for in-depth proteome profiling

Yejing Weng et al.

ANALYST (2016)

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Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

Mijung Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

Tek N. Lamichhane et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2016)

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Mechanisms of outer membrane vesicle entry into host cells

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Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

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OSTEOARTHRITIS AND CARTILAGE (2016)

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Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model

Ben Ma et al.

SCIENTIFIC REPORTS (2016)

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Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles' characteristics compared to precipitating agents

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Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

Li Hu et al.

SCIENTIFIC REPORTS (2016)

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Trehalose prevents aggregation of exosomes and cryodamage

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SCIENTIFIC REPORTS (2016)

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A novel platform for cancer therapy using extracellular vesicles

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ADVANCED DRUG DELIVERY REVIEWS (2015)

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The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells

Tovah Wolf et al.

JOURNAL OF NUTRITION (2015)

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Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

Jose M. Vicencio et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Curcumin Modulates Pancreatic Adenocarcinoma Cell-Derived Exosomal Function

Carlos J. Diaz Osterman et al.

PLOS ONE (2015)

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Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex

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VIROLOGY (2015)

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Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

Charles P. Lai et al.

NATURE COMMUNICATIONS (2015)

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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Optimized exosome isolation protocol for cell culture supernatant and human plasma

Richard J. Lobb et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Thomas Lener et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

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JOURNAL OF EXTRACELLULAR VESICLES (2015)

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miRNA in Plasma Exosome is Stable under Different Storage Conditions

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MOLECULES (2014)

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Human semen contains exosomes with potent anti-HIV-1 activity

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RETROVIROLOGY (2014)

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Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes

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JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Exosomes function in cell-cell communication during brain circuit development

Pranav Sharma et al.

CURRENT OPINION IN NEUROBIOLOGY (2013)

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Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

Yuki Takahashi et al.

JOURNAL OF BIOTECHNOLOGY (2013)

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Extracellular vesicles: Exosomes, microvesicles, and friends

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Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

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PLOS ONE (2013)

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Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Kenneth W. Witwer et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma

P. Torregrosa Paredes et al.

ALLERGY (2012)

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Hypoxic enhancement of exosome release by breast cancer cells

Hamish W. King et al.

BMC CANCER (2012)

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Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model

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Exosomes Derived from Immature Bone Marrow Dendritic Cells Induce Tolerogenicity of Intestinal Transplantation in Rats

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Efficacy of Systemically Administered Oncolytic Vaccinia Virotherapy for Malignant Gliomas Is Enhanced by Combination Therapy with Rapamycin or Cyclophosphamide

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CLINICAL CANCER RESEARCH (2009)

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Recommendations for the Use of Therapeutic Plasma

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CURRENT VASCULAR PHARMACOLOGY (2009)

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Membrane vesicles as conveyors of immune responses

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NATURE REVIEWS IMMUNOLOGY (2009)

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NATURE REVIEWS CANCER (2009)

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Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery

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KIDNEY INTERNATIONAL (2006)

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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes:: results of thefirst phase I clinical trial

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JOURNAL OF TRANSLATIONAL MEDICINE (2005)

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JOURNAL OF TRANSLATIONAL MEDICINE (2005)

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Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro

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BLOOD (2004)

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Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways

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JOURNAL OF CONTROLLED RELEASE (2003)

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