Related references
Note: Only part of the references are listed.Structure and Cooperativity in Substrate-Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design
Eerappa Rajakumara et al.
ACS CHEMICAL BIOLOGY (2022)
Biocatalysis making waves in organic chemistry
Ulf Hanefeld et al.
CHEMICAL SOCIETY REVIEWS (2022)
An Altered Heme Environment in an Engineered Cytochrome P450 Enzyme Enables the Switch from Monooxygenase to Peroxygenase Activity
Matthew N. Podgorski et al.
ACS CATALYSIS (2022)
Engineering of CYP153A33 With Enhanced Ratio of Hydroxylation to Overoxidation Activity in Whole-Cell Biotransformation of Medium-Chain 1-Alkanols
Hyuna Park et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)
Protein Engineering of an Artificial P450BM3 Peroxygenase System Enables Highly Selective O-Demethylation of Lignin Monomers
Maosheng Li et al.
MOLECULES (2022)
The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush
Mingxing Teng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2022)
NAD plus metabolism in peripheral neuropathic pain
Yi Dai et al.
NEUROCHEMISTRY INTERNATIONAL (2022)
Artificial metalloenzymes based on protein assembly
Basudev Maity et al.
COORDINATION CHEMISTRY REVIEWS (2022)
A perspective on the discovery of enzyme activators
Antonia Turberville et al.
SLAS DISCOVERY (2022)
The molecular basis and enzyme engineering strategies for improvement of coupling efficiency in cytochrome P450s
Shuaiqi Meng et al.
BIOTECHNOLOGY ADVANCES (2022)
Recent developments in the use of peroxygenases - Exploring their high potential in selective oxyfunctionalisations
Markus Hobisch et al.
BIOTECHNOLOGY ADVANCES (2021)
Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer
Yang Yang et al.
ACCOUNTS OF CHEMICAL RESEARCH (2021)
The Power of Deception: Using Decoy Molecules to Manipulate P450BM3 Biotransformations
Joshua Kyle Stanfield et al.
CHEMISTRY LETTERS (2021)
Efficient production of oxidized terpenoids via engineering fusion proteins of terpene synthase and cytochrome P450
Xi Wang et al.
METABOLIC ENGINEERING (2021)
Stereodivergent atom-transfer radical cyclization by engineered cytochromes P450
Qi Zhou et al.
SCIENCE (2021)
Expanding the Substrate Scope of Nitrating Cytochrome P450 TxtE by Active Site Engineering of a Reductase Fusion
Rakesh Saroay et al.
CHEMBIOCHEM (2021)
Chemogenetic Evolution of a Peroxidase-like Artificial Metalloenzyme
Ulrich Markel et al.
ACS CATALYSIS (2021)
New-to-nature chemistry from old protein machinery: carbene and nitrene transferases
Zhen Liu et al.
CURRENT OPINION IN BIOTECHNOLOGY (2021)
Switching an Artificial P450 Peroxygenase into Peroxidase via Mechanism-Guided Protein Engineering
Nana Ma et al.
ACS CATALYSIS (2021)
Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes
Emerald S. Ellis et al.
JACS AU (2021)
Enabling highly (R)-enantioselective epoxidation of styrene by engineering unique non-natural P450 peroxygenases
Panxia Zhao et al.
CHEMICAL SCIENCE (2021)
Dioxazolones: Stable Substrates for the Catalytic Transfer of Acyl Nitrenes
Kaj M. van Vliet et al.
ACS CATALYSIS (2020)
Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity
Giovanna Di Nardo et al.
TRENDS IN BIOCHEMICAL SCIENCES (2020)
Expanding the applicability of cytochrome P450s and other haemoproteins
Shinya Ariyasu et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2020)
Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology
Vlada B. Urlacher et al.
TRENDS IN BIOTECHNOLOGY (2019)
Strategies for Substrate-Regulated P450 Catalysis: From Substrate Engineering to Co-catalysis
Jiakun Xu et al.
CHEMISTRY-A EUROPEAN JOURNAL (2019)
Artificial Metalloenzymes: Challenges and Opportunities
Holly J. Davis et al.
ACS CENTRAL SCIENCE (2019)
Recent advances in heme biocatalysis engineering
Lisa Marie Schmitz et al.
BIOTECHNOLOGY AND BIOENGINEERING (2019)
Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals
Uwe T. Bornscheuer et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
Biocatalysis explained: from pharmaceutical to bulk chemical production
Eman M. M. Abdelraheem et al.
REACTION CHEMISTRY & ENGINEERING (2019)
Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase
Nana Ma et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Synthesis of chiral amines using redox biocatalysis
Gideon Grogan
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
Stereoselective hydroxylation of isophorone by variants of the cytochromes P450 CYP102A1 and CYP101A1
Shaghayegh Dezvarei et al.
ENZYME AND MICROBIAL TECHNOLOGY (2018)
Computational redesign of enzymes for regio- and enantioselective hydroamination
Ruifeng Li et al.
NATURE CHEMICAL BIOLOGY (2018)
Hydroclassified Combinatorial Saturation Mutagenesis: Reshaping Substrate Binding Pockets of KpADH for Enantioselective Reduction of Bulky-Bulky Ketones
Guo-Chao Xu et al.
ACS CATALYSIS (2018)
Unlocked potential of dynamic elements in protein structures: channels and loops
Nico Kress et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
Kai Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Manganese(V) Porphycene Complex Responsible for Inert C-H Bond Hydroxylation in a Myoglobin Matrix
Koji Ohora et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Chemoselective, Enzymatic C-H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor
Pawel Dydio et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene
Antonio Tinoco et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme
Christopher K. Prier et al.
NATURE CHEMISTRY (2017)
A reductive aminase from Aspergillus oryzae
Godwin A. Aleku et al.
NATURE CHEMISTRY (2017)
Control of stereoselectivity of benzylic hydroxylation catalysed by wild-type cytochrome P450BM3 using decoy molecules
Kazuto Suzuki et al.
CATALYSIS SCIENCE & TECHNOLOGY (2017)
Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives
Osami Shoji et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Enzymatic site-selectivity enabled by structure-guided directed evolution
Jian-bo Wang et al.
CHEMICAL COMMUNICATIONS (2017)
Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy
Christopher K. Prier et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity
Priyanka Bajaj et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Myoglobin-Catalyzed Olefination of Aldehydes
Vikas Tyagi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction
Vikas Tyagi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy
Roman Davydov et al.
BIOCHEMISTRY (2016)
Efficient conversion of primary azides to aldehydes catalyzed by active site variants of myoglobin
Simone Giovani et al.
CHEMICAL SCIENCE (2016)
Stereoselectivity and Structural Characterization of an Irvine Reductase (IRED) from Amycolatopsis orientalis
Godwin A. Aleku et al.
ACS CATALYSIS (2016)
A substrate-binding-state mimic of H2O2-dependent cytochrome P450 produced by one-point mutagenesis and peroxygenation of non-native substrates
Osami Shoji et al.
CATALYSIS SCIENCE & TECHNOLOGY (2016)
Significance and challenges of stereoselectivity assessing methods in drug metabolism
Zhuowei Shen et al.
JOURNAL OF PHARMACEUTICAL ANALYSIS (2016)
Enantioselective Enzymes by Computational Design and In Silico Screening
Hein J. Wijma et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Guidelines for development and implementation of biocatalytic P450 processes
Marie T. Lundemo et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)
Structure, Activity and Stereoselectivity of NADPH-Dependent Oxidoreductases Catalysing the S-Selective Reduction of the Imine Substrate 2-Methylpyrroline
Henry Man et al.
CHEMBIOCHEM (2015)
Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space
Dennis Wetzl et al.
CHEMBIOCHEM (2015)
Myoglobin-catalyzed intermolecular carbene N-H insertion with arylamine substrates
Gopeekrishnan Sreenilayam et al.
CHEMICAL COMMUNICATIONS (2015)
Acetate anion-triggered peroxygenation of non-native substrates by wild-type cytochrome P450s
Hiroki Onoda et al.
DALTON TRANSACTIONS (2015)
Intermolecular carbene S-H insertion catalysed by engineered myoglobin-based catalysts
Vikas Tyagi et al.
CHEMICAL SCIENCE (2015)
Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones
Ritesh Singh et al.
ACS CATALYSIS (2015)
Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
Christopher C. Farwell et al.
ACS CENTRAL SCIENCE (2015)
P450BM3-Axial Mutations: A Gateway to Non-Natural Reactivity
Todd K. Hyster et al.
ISRAEL JOURNAL OF CHEMISTRY (2015)
Bringing out the Potential of Wild-type Cytochrome P450s using Decoy Molecules: Oxygenation of Nonnative Substrates by Bacterial Cytochrome P450s
Osami Shoji et al.
ISRAEL JOURNAL OF CHEMISTRY (2015)
Enantioselective lmidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
Christopher C. Farwell et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
P450-Catalyzed Intramolecular sp3 C-H Amination with Arylsulfonyl Azide Substrates
Ritesh Singh et al.
ACS CATALYSIS (2014)
Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules
Osami Shoji et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Enantioselective Intramolecular C-H Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
John A. McIntosh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Unusual Cytochrome P450 Enzymes and Reactions
F. Peter Guengerich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
C(sp3)-H Bond Hydroxylation Catalyzed by Myoglobin Reconstituted with Manganese Porphycene
Koji Oohora et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo
Pedro S. Coelho et al.
NATURE CHEMICAL BIOLOGY (2013)
Effect of distal histidines on hydrogen peroxide activation by manganese reconstituted myoglobin
Yuan-Bo Cai et al.
METALLOMICS (2013)
Unusual properties of the cytochrome P450 superfamily
David C. Lamb et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2013)
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
Pedro S. Coelho et al.
SCIENCE (2013)
Inverting hydrolases and their use in enantioconvergent biotransformations
Markus Schober et al.
TRENDS IN BIOTECHNOLOGY (2013)
P450(BM3) (CYP102A1): connecting the dots
Christopher J. C. Whitehouse et al.
CHEMICAL SOCIETY REVIEWS (2012)
Chiral-Substrate-Assisted Stereoselective Epoxidation Catalyzed by H2O2-Dependent Cytochrome P450SPa
Takashi Fujishiro et al.
CHEMISTRY-AN ASIAN JOURNAL (2012)
Use of Perfluorocarboxylic Acids To Trick Cytochrome P450BM3 into Initiating the Hydroxylation of Gaseous Alkanes
Norifumi Kawakami et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Tuning a P450 Enzyme for Methane Oxidation
Felipe E. Zilly et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
The Conserved Trp-Cys Hydrogen Bond Dampens the Push Effect of the Heme Cysteinate Proximal Ligand during the First Catalytic Cycle of Nitric Oxide Synthase
Jerome Lang et al.
BIOCHEMISTRY (2011)
Design of H2O2-dependent oxidation catalyzed by hemoproteins
Osami Shoji et al.
METALLOMICS (2011)
Aromatic C-H bond hydroxylation by P450 peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on Russig's blue formation
Osami Shoji et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2010)
The Chromodomains of the Chd1 Chromatin Remodeler Regulate DNA Access to the ATPase Motor
Glenn Hauk et al.
MOLECULAR CELL (2010)
Catalytic C-H functionalization by metal carbenoid and nitrenoid insertion
Huw M. L. Davies et al.
NATURE (2008)
Development of a heme protein structureelectrochemical function database
Charles J. Reedy et al.
NUCLEIC ACIDS RESEARCH (2008)
Transition-metal-catalyzed group transfer reactions for selective C-H bond functionalization of artemisinin
Yungen Liu et al.
ORGANIC LETTERS (2007)
Hydrogen peroxide dependent monooxygenations by tricking the substrate recognition of cytochrome P450(BS beta)
Osami Shoji et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Complex reactions catalyzed by cytochrome P450 enzymes
Ernre M. Isin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Crystal structure and peroxidase activity of myoglobin reconstituted with iron porphycene
Takashi Hayashi et al.
INORGANIC CHEMISTRY (2006)
Phe393 mutants of cytochrome P450BM3 with modified heme redox potentials have altered heme vinyl and propionate conformations
ZC Chen et al.
BIOCHEMISTRY (2004)
Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis -: Crystallographic, spectroscopic, and mutational studies
DS Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Roles of the proximal hydrogen bonding network in cytochrome P450cam-catalyzed oxygenation
S Yoshioka et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
What factors affect the regioselectivity of oxidation by cytochrome P450? A DFT study of allylic hydroxylation and double bond epoxidation in a model reaction
SP de Visser et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
The 'push' effect of the thiolate ligand in cytochrome P450: a theoretical gauging
F Ogliaro et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
Replacement of active-site cysteine-436 by serine converts cytochrome P4502B4 into an NADPH oxidase with negligible monooxygenase activity
KP Vatsis et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
Isotope effects and intermediates in the reduction of NO by P450NOR
A Daiber et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2002)
New functionalization of myoglobin by chemical modification of heme-propionates
T Hayashi et al.
ACCOUNTS OF CHEMICAL RESEARCH (2002)
Phenylalanine 393 exerts thermodynamic control over the heme of flavocytochrome P450BM3
TWB Ost et al.
BIOCHEMISTRY (2001)
Roles of the proximal heme thiolate ligand in cytochrome P450cam
K Auclair et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)