4.7 Review

Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity

Anthony J. Treichel et al.

Summary: The gastrointestinal (GI) tract has intrinsic tactile sensitivity mediated by Piezo2+ EECs, allowing it to detect luminal forces and physical properties of luminal contents to modulate physiology.

GASTROENTEROLOGY (2022)

Review Gastroenterology & Hepatology

Gut feelings: mechanosensing in the gastrointestinal tract

Arnaldo Mercado-Perez et al.

Summary: Mechanosensation is crucial for normal gastrointestinal tract function and is often disrupted in gastrointestinal diseases. The gut contains various mechanosensory cells that can detect mechanical stimuli and coordinate physiological responses. Recent discoveries of mechanosensory molecules and understanding of related circuits have advanced our knowledge in this field.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Review Neurosciences

Neural signalling of gut mechanosensation in ingestive and digestive processes

Minyoo Kim et al.

Summary: Eating and drinking generate sequential mechanosensory signals along the digestive tract, which are important for the proper intake and digestion of nutrients and water. Recent discoveries of specific mechanoreceptors, ion channels, and neural circuits have expanded our understanding of these processes.

NATURE REVIEWS NEUROSCIENCE (2022)

Review Physiology

The role of mechanosensitive ion channels in the gastrointestinal tract

Haoyu Yang et al.

Summary: Mechanosensitive ion channels play important roles in gastrointestinal function by responding to mechanical forces through mechanoelectrical coupling. They are associated with gastrointestinal disorders, suggesting their potential as therapeutic targets for GI diseases.

FRONTIERS IN PHYSIOLOGY (2022)

Article Cell Biology

Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis

Xiaofei Wang et al.

Summary: The study revealed that Piezo1 plays a crucial role in gastric cancer omentum metastasis by promoting cell proliferation and migration, impacting intracellular Ca2+ influx through upregulation of HIF-1α, hence affecting tumor growth and metastasis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Biochemistry & Molecular Biology

Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface

Ivan P. Uray et al.

Summary: Mechanical signals are crucial for the survival, adaptation, and normal functioning of cells. Mechanotransduction, the process of converting mechanical information into intracellular biochemical signals, plays a key role in physiological and pathological processes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Gastroenterology & Hepatology

Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels

Vikram Joshi et al.

Summary: Mechanosensation is crucial for gastrointestinal function, with various cell types in the GI tract sensing and transducing mechanical forces into physiological responses. Mechanosensitive cells like sensory neurons and smooth muscle cells play important roles in detecting and responding to mechanical stimuli. This process involves mechano-gated and mechanosensitive ion channels, contributing to rapid mechanotransduction responses.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Epidemiology and Burden of Irritable Bowel Syndrome An International Perspective

Ami D. Sperber

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2021)

Article Multidisciplinary Sciences

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

Hamza Atcha et al.

Summary: Studies reveal that Piezo1 serves as a mechanosensor of stiffness in macrophages, influencing their polarization responses.

NATURE COMMUNICATIONS (2021)

Article Gastroenterology & Hepatology

CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity

Tibor Docsa et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

Article Chemistry, Multidisciplinary

Mechanical Distension Induces Serotonin Release from Intestine as Revealed by Stretchable Electrochemical Sensing

Yan-Ling Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Immunology

TRPV4-A Missing Link Between Mechanosensation and Immunity

Laura Michalick et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Multidisciplinary Sciences

Discoveries in structure and physiology of mechanically activated ion channels

J. M. Kefauver et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis

Jinglin Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Nutrition & Dietetics

Incidence and Effects of Feeding Intolerance in Trauma Patients

Farrukh R. Virani et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2019)

Review Endocrinology & Metabolism

In Pursuit of the Epithelial Mechanosensitivity Mechanisms

Arthur Beyder

FRONTIERS IN ENDOCRINOLOGY (2019)

Article Gastroenterology & Hepatology

Role of transient receptor potential melastatin 2 in surgical inflammation an dysmotility in a mouse model of postoperative ileus

Kenjiro Matsumoto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Gastroenterology & Hepatology

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity

Peter R. Strege et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Neurosciences

The touchy business of gastrointestinal (GI) mechanosensitivity

Anthony J. Treichel et al.

BRAIN RESEARCH (2018)

Article Cell Biology

Muscularis macrophages: Key players in intestinal homeostasis and disease

Sebastiaan De Schepper et al.

CELLULAR IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Constanza Alcaino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Neurosciences

Meal-Sensing Signaling Pathways in Functional Dyspepsia

Amanda J. Page et al.

FRONTIERS IN SYSTEMS NEUROSCIENCE (2018)

Article Cell Biology

Mechanosensitive ion channel Piezo1 is expressed in antral G cells of murine stomach

Kerstin Lang et al.

CELL AND TISSUE RESEARCH (2018)

Article Biochemistry & Molecular Biology

TRPV4 calcium-permeable channel is a novel regulator of oxidized LDL-induced macrophage foam cell formation

Rishov Goswami et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Gastroenterology & Hepatology

Transient receptor potential ion channel function in sensory transduction and cellular signaling cascades underlying visceral hypersensitivity

Dafne Balemans et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2017)

Article Neurosciences

The potential role of Piezo2 in the mediation of visceral sensation

Jing Yang et al.

NEUROSCIENCE LETTERS (2016)

Review Surgery

Postoperative ileus: Pathophysiology, incidence, and prevention

A. Venara et al.

JOURNAL OF VISCERAL SURGERY (2016)

Article Gastroenterology & Hepatology

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells

Leila Neshatian et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Article Neurosciences

Mechanical stress activates neurites and somata of myenteric neurons

Eva M. Kugler et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Biochemistry & Molecular Biology

Physical and mechanical regulation of macrophage phenotype and function

Frances Y. McWhorter et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

Article Peripheral Vascular Disease

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

Nadine Jetten et al.

ANGIOGENESIS (2014)

Article Engineering, Biomedical

Strain-dependent modulation of macrophage polarization within scaffolds

Virginia Ballotta et al.

BIOMATERIALS (2014)

Article Multidisciplinary Sciences

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

Sanjeev S. Ranade et al.

NATURE (2014)

Article Gastroenterology & Hepatology

TRPV2 ion channels expressed in inhibitory motor neurons of gastric myenteric plexus contribute to gastric adaptive relaxation and gastric emptying in mice

Hiroshi Mihara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Multidisciplinary Sciences

Mechanosensitive Enteric Neurons in the Myenteric Plexus of the Mouse Intestine

Gemma Mazzuoli et al.

PLOS ONE (2012)

Review Gastroenterology & Hepatology

Targeting ion channels for the treatment of gastrointestinal motility disorders

Arthur Beyder et al.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2012)

Article Gastroenterology & Hepatology

Mechanisms underlying distension-evoked peristalsis in guinea pig distal colon: is there a role for enterochromaffin cells?

Nick J. Spencer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)

Article Gastroenterology & Hepatology

Mechanosensitivity of STREX-lacking BKCa channels in the colonic smooth muscle of the mouse

Wei Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Article Gastroenterology & Hepatology

Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages

Sven Wehner et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)

Article Critical Care Medicine

Nuclear factor-κB activation by edema inhibits intestinal contractile activity

Karen S. Uray et al.

CRITICAL CARE MEDICINE (2010)

Article Gastroenterology & Hepatology

Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

Volodymyr V. Tsvilovskyy et al.

GASTROENTEROLOGY (2009)

Article Gastroenterology & Hepatology

The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli

Stuart M. Brierley et al.

GASTROENTEROLOGY (2009)

Review Gastroenterology & Hepatology

Neuroimmune mechanisms in postoperative ileus

G. E. Boeckxstaens et al.

Article Gastroenterology & Hepatology

Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice

Klaus Bielefeldt et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Gastroenterology & Hepatology

Selective role for TRPV4 ion channels in visceral sensory pathways

Stuart M. Brierley et al.

GASTROENTEROLOGY (2008)

Article Critical Care Medicine

Hypertonic saline modulation of intestinal tissue stress and fluid balance

Charles S. Cox et al.

SHOCK (2008)

Article Critical Care Medicine

Edema-induced intestinal dysfunction is mediated by stat3 activation

Karen S. Uray et al.

SHOCK (2007)

Review Gastroenterology & Hepatology

Mechanosensitive ion channels in interstitial cells of Cajal and smooth muscle of the gastrointestinal tract

R. E. Kraichely et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2007)

Review Gastroenterology & Hepatology

The serotonin signaling system: From basic understanding to drug development-for functional GI disorders

Michael D. Gershon et al.

GASTROENTEROLOGY (2007)

Article Neurosciences

Real-time measurement of serotonin release and motility in guinea pig ileum

Paul P. Bertrand

JOURNAL OF PHYSIOLOGY-LONDON (2006)

Article Gastroenterology & Hepatology

Interstitial cells of Cajal and adaptive relaxation in the mouse stomach

Devika Dixit et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Neurosciences

Characterization of myenteric sensory neurons in the mouse small intestine

Yukang Mao et al.

JOURNAL OF NEUROPHYSIOLOGY (2006)

Article Neurosciences

Two-pore-domain potassium channels in smooth muscles: new components of myogenic regulation

KM Sanders et al.

JOURNAL OF PHYSIOLOGY-LONDON (2006)

Letter Gastroenterology & Hepatology

The many facets of intestinal peristalsis

JD Huizinga et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)

Article Gastroenterology & Hepatology

Spatiotemporal electrical and motility mapping of distension-induced propagating oscillations in the murine small intestine

TC Seerden et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

Article Multidisciplinary Sciences

Interstitial cells of Cajal mediate mechanosensitive responses in the stomach

KJ Won et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Gastroenterology & Hepatology

Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility

NT Schwarz et al.

GASTROENTEROLOGY (2004)

Article Cell Biology

Cytoskeletal modulation of sodium current in human jejunal circular smooth muscle cells

PR Strege et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)

Article Gastroenterology & Hepatology

Sodium current in human intestinal interstitial cells of Cajal

PR Strege et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)

Review Pharmacology & Pharmacy

Ion channels in gastrointestinal smooth muscle and interstitial cells of Cajal

GL Lyford et al.

CURRENT OPINION IN PHARMACOLOGY (2003)

Article Neurosciences

A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon

NJ Spencer et al.

JOURNAL OF PHYSIOLOGY-LONDON (2002)

Article Cell Biology

α1C (Cav1.2) L-type calcium channel mediates mechanosensitive calcium regulation

GL Lyford et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)

Article Neurosciences

Stretch-dependent potassium channels in murine colonic smooth muscle cells

SD Koh et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

Article Neurosciences

Role of muscle tone in peristalsis in guinea-pig small intestine

NJ Spencer et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)