4.7 Article

Regorafenib and Ruthenium Complex Combination Inhibit Cancer Cell Growth by Targeting PI3K/AKT/ERK Signalling in Colorectal Cancer Cells

Related references

Note: Only part of the references are listed.
Article Chemistry, Inorganic & Nuclear

Evaluation of anticancer activity of ferrocene based benzothiazole and beta-ketooxothioacetal

Archana Ranjan et al.

Summary: Ferrocene-based compounds have gained importance in cancer treatment due to their lower toxicity and cost-effective synthesis. In this study, thianes containing ferrocene were synthesized and their synergistic effect with thiol was observed in suppressing tumor growth. These compounds showed significant anticancer effects by inducing apoptosis and inhibiting cell migration. The ferrocene-based compounds have the potential to serve as a platform for the development of new anticancer agents, replacing rare metal compounds.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2022)

Article Chemistry, Applied

In vitro evaluation of cytotoxicity and antimetastatic properties of novel arene ruthenium(II)-tetrazolato compounds on human cancer cell lines

Komal M. Vyas et al.

Summary: Two new arene ruthenium(II) complexes were synthesized and screened for cytotoxic activity, with one showing higher cytotoxicity against cancer cell lines and the other exhibiting anti-migratory properties.

APPLIED ORGANOMETALLIC CHEMISTRY (2021)

Review Medicine, General & Internal

Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review

Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Pharmacology & Pharmacy

Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Argyreia nervosa Extract in Colorectal Cancer Cells

Fayyaz Rasool et al.

Summary: The study demonstrates the anticancer activity of GIV against HCT116 cell line, affecting apoptosis-related genes, suggesting its potential as a lead or supplementary molecule for treating and preventing CRC.

FRONTIERS IN PHARMACOLOGY (2021)

Article Chemistry, Multidisciplinary

A RuII Polypyridyl Alkyne Complex Based Metal-Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy

Xiaochun Hu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2020)

Article Biochemistry & Molecular Biology

The Synergistic Anti-Cancer Effects of NVP-BEZ235 and Regorafenib in Hepatocellular Carcinoma

Cheng-Chan Yu et al.

MOLECULES (2020)

Review Biochemistry & Molecular Biology

Overcoming cancer therapeutic bottleneck by drug repurposing

Zhe Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Biochemistry & Molecular Biology

Targeting PI3K in cancer: mechanisms and advances in clinical trials

Jing Yang et al.

MOLECULAR CANCER (2019)

Article Cell Biology

In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis

Jordi Pijuan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Chemistry, Multidisciplinary

Stimuli-Responsive Therapeutic Metallodrugs

Xiaohui Wang et al.

CHEMICAL REVIEWS (2019)

Review Oncology

Tumour heterogeneity and resistance to cancer therapies

Ibiayi Dagogo-Jack et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells

Maria Grazia Refolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Chemistry, Medicinal

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

Sreekanth Thota et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Pharmacology & Pharmacy

Applications of Ruthenium Complex in Tumor Diagnosis and Therapy

Ke Lin et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Chemistry, Multidisciplinary

Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications

Sabyasachi Chakrabortty et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Biochemistry & Molecular Biology

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

Kaja C. G. Berg et al.

MOLECULAR CANCER (2017)

Review Chemistry, Multidisciplinary

The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials

Leli Zeng et al.

CHEMICAL SOCIETY REVIEWS (2017)

Review Chemistry, Multidisciplinary

Functionalization of Platinum Complexes for Biomedical Applications

Xiaoyong Wang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2015)

Review Multidisciplinary Sciences

AKT Kinase Pathway: A Leading Target in Cancer Research

Ambuj Kumar et al.

SCIENTIFIC WORLD JOURNAL (2013)

Editorial Material Pharmacology & Pharmacy

Regorafenib for cancer

Dirk Strumberg et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2012)

Review Biochemistry & Molecular Biology

Approaching tumour therapy beyond platinum drugs Status of the art and perspectives of ruthenium drug candidates

A. Bergamo et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2012)

Editorial Material Oncology

Combinations Go on Trial

Cathryn Delude

CANCER DISCOVERY (2012)

Article Multidisciplinary Sciences

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

Danli Wu et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

Article Chemistry, Inorganic & Nuclear

Ruthenium Polypyridyl Complexes That Induce Mitochondria-Mediated Apoptosis in Cancer Cells

Tianfeng Chen et al.

INORGANIC CHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

Tina M. Thornton et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2009)

Article Cell Biology

Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma

Hung Huynh et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

Review Biochemistry & Molecular Biology

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

James A. McCubrey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Review Biochemistry & Molecular Biology

MAP kinase signalling pathways in cancer

A. S. Dhillon et al.

ONCOGENE (2007)

Article Biochemical Research Methods

Analysis of apoptosis by propidium iodide staining and flow cytometry

Carlo Riccardi et al.

NATURE PROTOCOLS (2006)

Article Pharmacology & Pharmacy

Antioxidants and oxidants regulated signal transduction pathways

ED Owuor et al.

BIOCHEMICAL PHARMACOLOGY (2002)