Diet and Proteinuria: State of Art

Proteinuria is a broad term used to describe the pathological presence of proteins, including albumin, globulin, Bence-Jones protein, and mucoprotein in the urine. When persistent, proteinuria is a marker of kidney damage and represents a reliable predictor of the risk of progression of renal failure. Medical nutrition therapy is imperative for patients with proteinuria because it may slow the progression of renal disease. The aim of this review is to explore different nutritional approaches in the management of proteinuria and their influence on pathophysiological processes. As such, protein restriction is the main dietary intervention. Indeed, other management approaches are frequently used to reduce it regarding micro and macronutrients, but also the dietary style. Among these, the nutritional approach represents one of the most used and controversial interventions and the studies rarely take the form of randomized and controlled trials. With this work we aspire to analyze current clinical knowledge of how nutrition could influence proteinuria, potentially representing a useful tool in the management of proteinuric nephropathy.

Automated summary

Proteinuria refers to the presence of proteins in the urine, indicating kidney damage and predicting the risk of renal failure progression. Medical nutrition therapy is crucial in slowing the progression of renal disease for patients with proteinuria. The main dietary intervention is protein restriction, although other approaches targeting micro and macronutrients and dietary style are also frequently used. However, there is a lack of randomized and controlled trials studying nutritional interventions for proteinuria.