Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice

Article Clinical Neurology

Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model

Tzu-Ting Liu et al.

Summary: Our study provides insight on optimal nVNS parameters to suppress CSD and suggests its benefit on CSD-induced neuroinflammation and trigeminovascular activation in migraine treatment.

JOURNAL OF HEADACHE AND PAIN (2022)

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Article Pharmacology & Pharmacy

In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes

Mikina Takiyama et al.

Summary: Kampo medicines are widely used in Japan, but their potential to cause drug interactions is still unclear. This study investigated the inhibitory effects of goreisan, a Kampo medicine, on P-glycoprotein (P-gp) and cytochrome P-450 (CYP), which are associated with drug interactions. The results showed that goreisan extract has inhibitory activity against P-gp and that one of its ingredients, alisol A, exhibits an inhibitory effect on CYP3A. However, these effects are likely to be minor or negligible in vivo.

XENOBIOTICA (2022)

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Correction Clinical Neurology

GBD 2016 Headache Collaborators. Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 (vol 17, pg 954, 2018)

Ali H. Mokdad

LANCET NEUROLOGY (2021)

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Review Neurosciences

Implications of Transient Receptor Potential Cation Channels in Migraine Pathophysiology

Mamoru Shibata et al.

Summary: Migraine is a common and debilitating headache disorder with elusive pathogenesis, likely involving abnormal trigeminal and central nervous system activity. TRP channels, which transduce noxious stimuli into pain signals, play important roles in migraine pathophysiology by co-localizing with calcitonin gene-related peptide in the trigeminal ganglion and regulating its release. Effective anti-migraine therapies, such as botulinum neurotoxin type A, also impact TRP cation channel functions.

NEUROSCIENCE BULLETIN (2021)

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Review Medicine, General & Internal

Migraine: epidemiology and systems of care

Messoud Ashina et al.

Summary: Migraine is a global neurovascular disorder that has negative impacts on patients, families, and society. Integrated and coordinated care systems can help reduce this burden. Low and middle-income countries face challenges in migraine care due to inadequate public health education and access to medication.

LANCET (2021)

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Article Endocrinology & Metabolism