4.7 Article

Antibodies against HSV-1 and Curli Show the Highest Correlation in Parkinson's Disease Patients in Comparison to Healthy Controls

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Epstein-Barr Virus and Neurological Diseases

Nan Zhang et al.

Summary: This paper reviews the mechanisms underlying the role of EBV in the development of central nervous system diseases, discussing its effects on neurons and glial cells, as well as its promotion of proliferative disorders in B and T lymphocytes. However, the specific underlying molecular mechanisms remain unclear.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Review Health Care Sciences & Services

Gastrointestinal Dysfunction in Parkinson's Disease: Current and Potential Therapeutics

Myat Noe Han et al.

Summary: Abnormalities in the gastrointestinal tract are common in Parkinson's disease, causing non-motor symptoms that impact patient quality of life. Current treatments are ineffective in PD patients, highlighting the need for novel therapeutic approaches. This review discusses the potential of targeting the intestinal barrier, enteric nervous system, and/or gut microbiome to alleviate PD-related gastrointestinal symptoms, and explores emerging therapies and repurposed drugs.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Review Cell Biology

Alpha-Synuclein Aggregation Pathway in Parkinson's Disease: Current Status and Novel Therapeutic Approaches

Marija Vidovic et al.

Summary: Parkinson's disease (PD) is the second-most common neurodegenerative disorder and lacks disease-modifying therapy. Aggregation of alpha-synuclein (alpha-Syn) is closely associated with PD, and current therapeutic strategies primarily focus on targeting alpha-Syn using small molecules and peptides. Other approaches such as gene silencing, cell transplantation, and immunotherapy are also being explored.

CELLS (2022)

Review Clinical Neurology

Porphyromonas gingivalis: A key role in Parkinson's disease with cognitive impairment?

Dongcheng Li et al.

Summary: Cognitive impairment is a common complication of Parkinson's disease, and the convergence of alpha-Synuclein and Alzheimer's disease-like pathologies, neuroinflammation, and dysbiosis of gut microbiota are major features of Parkinson's disease with cognitive impairment. Recent research suggests a potential role of Porphyromonas gingivalis in the pathogenesis of both Parkinson's disease and Alzheimer's disease, particularly in relation to neuroinflammation and the deposition of alpha-Synuclein and amyloid-beta.

FRONTIERS IN NEUROLOGY (2022)

Review Geriatrics & Gerontology

The Association Between the Gut Microbiota and Parkinson's Disease, a Meta-Analysis

Ting Shen et al.

Summary: This meta-analysis revealed lower abundance levels of Prevotellaceae, Faecalibacterium, and Lachnospiraceae, and higher abundance levels of Bifidobacteriaceae, Ruminococcaceae, Verrucomicrobiaceae, and Christensenellaceae in patients with PD compared to HCs.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Review Immunology

Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases

Amanda L. Miller et al.

Summary: The human microbiota is a complex community of microorganisms, with the gut microbiota mainly composed of bacteria. Changes in bacterial species and biofilms within the gut microbiome can impact the progression of various human diseases. Bacterial amyloid curli, found within biofilms of commensal and pathogenic bacteria, may contribute to inflammatory processes in complex human diseases.

FRONTIERS IN IMMUNOLOGY (2021)

Review Physiology

Periodontal Inflammation and Systemic Diseases: An Overview

Mireya Martinez-Garcia et al.

Summary: Periodontitis is a common inflammatory disease that can progress into a systemic condition, causing systemic alterations and potentially exacerbating other health issues. The relationships between periodontitis and its related diseases are not fully understood, but a large body of evidence on different sources of information is available.

FRONTIERS IN PHYSIOLOGY (2021)

Article Medicine, General & Internal

Humoral Response to Microbial Biomarkers in Rheumatoid Arthritis Patients

Seyedesomaye Jasemi et al.

Summary: The study revealed a significantly increased humoral response against multiple pathogens in patients with rheumatoid arthritis, showing a notable difference compared to healthy controls. The intensity and prevalence of antibody response were also significantly correlated with rheumatoid factors.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Neurosciences

Microbial Infections Are a Risk Factor for Neurodegenerative Diseases

Sarah K. Lotz et al.

Summary: Neurodegenerative diseases are characterized by progressive loss of nervous system function, with neuroinflammation playing a role in their development. Microbial infections can trigger inflammatory responses in the central nervous system, potentially contributing to neurodegeneration. Understanding the mechanisms by which microbial infections increase susceptibility to neurodegenerative diseases is crucial for developing targeted therapeutic approaches.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Article Immunology

A Possible Role for HSV-1-Specific Humoral Response and PILRA rs1859788 Polymorphism in the Pathogenesis of Parkinson's Disease

Simone Agostini et al.

Summary: Parkinson's disease is a progressive nervous system disorder with unknown etiology, but with possible involvement of herpes simplex virus type 1. The PILRA gene polymorphism may also play a role in PD.

VACCINES (2021)

Article Microbiology

HERV-W and Mycobacterium avium subspecies paratuberculosis Are at Play in Pediatric Patients at Onset of Type 1 Diabetes

Marta Noli et al.

Summary: The etiology of T1D remains unknown, with emerging evidence suggesting a potential role of endogenous human retroviruses and MAP in triggering autoimmunity. External infections and internal reactivations may be involved in the disease etiology, with HERV-W activation potentially induced by infectious agents like MAP.

PATHOGENS (2021)

Article Multidisciplinary Sciences

Herpes simplex virus infection, Acyclovir and IVIG treatment all independently cause gut dysbiosis

Chandran Ramakrishna et al.

PLOS ONE (2020)

Review Immunology

Exploring the Multiple-Hit Hypothesis of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Kristin L. Patrick et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Review Microbiology

Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications

Sarah A. Tursi et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2018)

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

Review Pathology

Links between atherosclerotic and periodontal disease

Dimitry A. Chistiakov et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2016)

Article Immunology

Is there a role for Mycobacterium avium subspecies paratuberculosis in Parkinson's disease?

Giannina Arru et al.

JOURNAL OF NEUROIMMUNOLOGY (2016)

Article Clinical Neurology

Human serum antibodies against EBV latent membrane protein 1 cross-react with α-synuclein

John Woulfe et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2016)

Review Clinical Neurology

Gastrointestinal dysfunction in Parkinson's disease

Alfonso Fasano et al.

LANCET NEUROLOGY (2015)

Article Clinical Neurology

Hypothesis: A role for EBV-induced molecular mimicry in Parkinson's disease

John M. Woulfe et al.

PARKINSONISM & RELATED DISORDERS (2014)

Article Dentistry, Oral Surgery & Medicine

Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment

N. Makiura et al.

ORAL MICROBIOLOGY AND IMMUNOLOGY (2008)

Article Neurosciences

Plasma α-synuclein is decreased in subjects with Parkinson's disease

Qiao-Xin Li et al.

EXPERIMENTAL NEUROLOGY (2007)