The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

Review Biochemistry & Molecular Biology

The role of polyphenols in overcoming cancer drug resistance: a comprehensive review

Maleki Parisa Dana et al.

Summary: Polyphenols, natural compounds with beneficial properties, can increase the sensitivity of cancer cells to chemotherapeutic agents and affect other mechanisms for overcoming chemoresistance in cancer cells.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Review Oncology

Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review

A. Hazafa et al.

Summary: Natural polyphenols, such as phenolic acids, lignans, and stilbenes, are suggested as potent anticancer drugs due to their ability to induce apoptosis, cell cycle arrest, and inhibit cell proliferation in various cancer cells. They may serve as a viable therapeutic option for cancer treatment in the near future.

CLINICAL & TRANSLATIONAL ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers

Adele Chimento et al.

Summary: Estrogen stimulates cancer cell growth and inhibits apoptosis through estrogen receptor-mediated mechanisms, but can also induce apoptosis by activating different estrogen receptor isoforms. The exact mechanism of estrogen-induced tumor regression is still not fully understood, and the expression levels and cellular localization of different estrogen receptor splice variants can affect the outcome of estrogen-dependent tumors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Enzymatic Oxidation of Tea Catechins and Its Mechanism

Buhailiqiemu Abudureheman et al.

Summary: This review summarizes the data on the enzymatic oxidation of catechins, their dimers, and thearubigins in tea.

MOLECULES (2022)

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Review Biochemistry & Molecular Biology

Flavanols from Nature: A Phytochemistry and Biological Activity Review

Yu Luo et al.

Summary: Flavanols, a common class of secondary plant metabolites, have beneficial health properties and are considered functional ingredients in dairy products. Research on flavanols and their derivatives lays the groundwork for further studies.

MOLECULES (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Review Food Science & Technology

Anthocyanin supplement as a dietary strategy in cancer prevention and management: A comprehensive review

Jiali Chen et al.

Summary: Anthocyanins, natural pigments, have been shown to have positive effects in cancer prevention and management without side effects. This review summarizes the latest research on the anti-cancer effects of anthocyanins and their mechanisms. Studies have demonstrated that anthocyanins are beneficial for human health with anti-cancer capacity.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Food Science & Technology

A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives

Sayeh Mottaghi et al.

Summary: Lignans, as polyphenolic compounds, have beneficial effects against cancer by inducing cancer cell death and interfering with carcinogenesis, tumor growth, and metastasis. Their intake is inversely associated with the risk of several cancers, and they suppress cancer cell proliferation with minimal toxicity against non-transformed cells.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Review Multidisciplinary Sciences

Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review

Md Sohel et al.

Summary: This study summarizes the sources, pharmacological properties, and anticancer activities of Hesperetin (HSP) against various types of cancer. The results show that HSP can suppress tumor formation by targeting multiple cellular proteins and has the potential to overcome multidrug resistance. It also demonstrates better pharmacokinetic properties, making it a promising alternative drug for cancer treatment.

HELIYON (2022)

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Review Biochemistry & Molecular Biology

Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical Application-A comprehensive review

Tekleab Teka et al.

Summary: This review provides a comprehensive overview of Stilbene's botanical sources, chemistry, biosynthetic pathways, pharmacology, and clinical applications and challenges.

PHYTOCHEMISTRY (2022)

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Article Multidisciplinary Sciences

Mutational signatures are markers of drug sensitivity of cancer cells

Jurica Levati et al.

Summary: By analyzing mutational signatures in cancer cell lines, this study identifies robust associations between these signatures and drug activity, providing a valuable resource for drug repurposing guided by mutational signature markers.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines

Amani A. Mahbub et al.

Summary: This study analyzed the effect of Apigenin combined with etoposide or cyclophosphamide on apoptosis-related genes and proteins, and revealed the mechanisms of action, providing new insights into combination therapy for leukemia treatment.

SCIENTIFIC REPORTS (2022)

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Article Biotechnology & Applied Microbiology

Epigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β-catenin signalling pathway

Chaoqun Dong et al.

Summary: Epigallocatechin-3-gallate (EGCG), a unique catechin from tea leaves, has potential anticancer effects in osteosarcoma. Cellular and animal experiments have shown that EGCG promotes apoptosis and inhibits proliferation, migration, and invasion of osteosarcoma cells. EGCG also suppresses tumor cell damage to bone and distant lung metastasis.

BIOENGINEERED (2022)

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Article Chemistry, Medicinal

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

Angela De Luca et al.

Summary: Resveratrol (RSV) exhibits multiple tumor-suppressing activities on osteosarcoma (OS) cell lines, including inhibition of cell growth, promotion of cell differentiation, inhibition of cell migration, and enhancement of cytotoxic effect in combination with chemotherapy.

PHARMACEUTICALS (2022)

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Review Nutrition & Dietetics

Intake of Soy, Soy Isoflavones and Soy Protein and Risk of Cancer Incidence and Mortality

Yahui Fan et al.

Summary: Meta-analysis revealed that higher soy and soy isoflavones intake were inversely associated with cancer incidence, with a 4% reduction in risk for each additional 25g/d of soy intake and 10mg/d of soy isoflavones intake. Soy protein intake showed no significant association with cancer incidence.

FRONTIERS IN NUTRITION (2022)

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Article Chemistry, Medicinal

Quercetin and Methotrexate in Combination have Anticancer Activity in Osteosarcoma Cells and Repress Oncogenic MicroRNA-223

Erfan Mohammadi et al.

Summary: The study found that quercetin, a polyphenolic flavonoid with anti-tumor effects, can enhance the cytotoxicity of methotrexate (MTX) on osteosarcoma cells. The combination therapy can up-regulate tumor suppressor genes and down-regulate anti-apoptotic genes, inhibiting cell proliferation and inducing apoptosis.

DRUG RESEARCH (2022)

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Review Oncology

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

Parina Asgharian et al.

Summary: This article discusses the anticancer properties of quercetin as a natural bioactive compound. Quercetin inhibits tumor proliferation, invasion, and metastasis by modulating multiple signaling pathways and miRNA expression. Understanding the anticancer mechanisms of quercetin can help prevent and manage various types of cancer.

CANCER CELL INTERNATIONAL (2022)

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Article Biochemistry & Molecular Biology

Dimeric-(-)-epigallocatechin-3-gallate inhibits the proliferation of lung cancer cells by inhibiting the EGFR signaling pathway

Xiu-Li Sun et al.

Summary: The active substance PBOG in green tea inhibits the proliferation and migration of non-small cell lung cancer cells, promotes cell apoptosis, and inhibits cell cycle progression. It can also change the secondary structure of the protein, inhibit EGFR phosphorylation, and inhibit tumor growth.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

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Article Biochemistry & Molecular Biology

Curcumin Induces Apoptosis of Chemoresistant Lung Cancer Cells via ROS-Regulated p38 MAPK Phosphorylation

Ming-Fang Wu et al.

Summary: Curcumin induces apoptosis in chemoresistant lung cancer cells through generation of ROS, and p38 MAPK is identified as a crucial signaling pathway for this process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

The impact of rare germline variants on human somatic mutation processes

Mischan Vali-Pour et al.

Summary: Somatic mutations play a crucial role in aging and cancer, with rare inherited variants potentially influencing mutational processes. Specific genes are associated with different forms of DNA repair deficiencies, and interactions between genes in cellular sub-networks are common. Damaging variants in newly-identified genes are prevalent in the population, highlighting the impact of germline variants on somatic mutations in cancer.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells

Halima Alsamri et al.

Summary: In this study, it was found that carnosol induces apoptotic and autophagic cell death in breast cancer cells through ROS-dependent ER stress, demonstrating its anti-malignant activity.

FRONTIERS IN ONCOLOGY (2022)

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Review Biochemistry & Molecular Biology

Effects and Mechanisms of Curcumin for the Prevention and Management of Cancers: An Updated Review

Zhi-Jun Yang et al.

Summary: This article provides an updated review on the prevention and management of cancers using curcumin, with a special focus on its mechanisms of action. Curcumin exhibits various anticancer properties and has been shown to inhibit cell proliferation and promote cell apoptosis. Clinical trials have also confirmed its anticancer effects. Furthermore, the use of nanotechnologies can enhance the bioavailability of curcumin.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance

Alina Florentina Vladu et al.

Summary: Polyphenols have shown potential as antineoplastic agents in cancer treatment. They can be combined with cytostatic drugs to enhance therapeutic effects and protect healthy cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Curcumin Sensitises Cancerous Kidney Cells to TRAIL Induced Apoptosis via Let-7C Mediated Deregulation of Cell Cycle Proteins and Cellular Metabolism

Ismael Obaidi et al.

Summary: This study utilized curcumin to enhance the sensitivity of TRAIL-resistant kidney cancer cells and investigated the molecular mechanisms involved. Curcumin targeted the ACHN cell cycle and cellular metabolism by regulating the expression of let-7C.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Hesperetin induces apoptosis in A549 cells via the Hsp70-mediated activation of Bax

Masaya Tanaka et al.

Summary: Hesperetin exerts its anticancer activity by inducing cell apoptosis and inhibiting cell proliferation, with Hsp70 playing a critical role in the negative regulation of this process.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Article Chemistry, Physical

Curcumin selectively induces colon cancer cell apoptosis and S cell cycle arrest by regulates Rb/E2F/p53 pathway

Peihua Li et al.

Summary: Curcumin exhibits anti-colon cancer properties by inhibiting cell proliferation and inducing apoptosis through p53-mediated mechanisms.

JOURNAL OF MOLECULAR STRUCTURE (2022)

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Correction Oncology

Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial-mesenchymal transition via the AKT/GSK-3β/Snail signaling pathway (vol 20, pg 2783, 2019)

Li Yuan et al.

MOLECULAR MEDICINE REPORTS (2022)

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Review Biochemistry & Molecular Biology

The Potential Role of Apigenin in Cancer Prevention and Treatment

Arshad Husain Rahmani et al.

Summary: Cancer is the leading cause of death worldwide. Current cancer treatments cause adverse effects and kill normal cells, highlighting the need for more effective and less harmful approaches. Medicinal plants or their bioactive ingredients offer promising alternatives with less side effects and potential to reduce resistance against cancer therapy. Apigenin, a plant-derived flavonoid, has been extensively studied for its ability to modulate various cell signaling pathways and has shown anti-cancer potential. Further research and clinical trials are needed to explore its role and mechanisms of action in cancer management.

MOLECULES (2022)

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Article Plant Sciences

Genistein-induced mitochondrial dysfunction and FOXO3a/PUMA expression in non-small lung cancer cells

Liujia Chan et al.

Summary: This study demonstrates the activity of Genistein on non-small lung cancer cells by inducing mitochondrial apoptosis. Results showed that Genistein increased intracellular ROS generation, decreased mitochondrial membrane potential, and down-regulated mitochondrial activity. Furthermore, the expression level of mitochondrial apoptosis-related proteins was up-regulated by Genistein.

PHARMACEUTICAL BIOLOGY (2022)

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Review Cell Biology

Recent updates on anticancer mechanisms of polyphenols

Eshita Sharma et al.

Summary: This article discusses the importance of anticancer herbal compounds in cancer treatment, particularly polyphenols. Polyphenols have been proven to effectively inhibit tumor growth with fewer side effects and can enhance the sensitivity of cells to other therapies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Polyphenols in Metabolic Diseases

Amin Gasmi et al.

Summary: Polyphenols are a group of phytochemicals with phenolic rings and hydroxyl groups. They have strong antioxidant properties and therapeutic effects, and can alleviate various symptoms associated with metabolic disorders. Exploring the bioprotective properties and mechanisms of polyphenols can lead to the production of dietary and medicinal plans rich in these compounds.

MOLECULES (2022)

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Article Oncology

Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved

Ergul Mutlu Altundag et al.

Summary: Flavonoids have chemo-preventive and chemotherapeutic properties, with quercetin and curcumin showing beneficial synergistic effects on human cancer cells, specifically chronic myeloid leukemia cells through various signaling pathways.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Review Nutrition & Dietetics

Evolving Interplay Between Dietary Polyphenols and Gut Microbiota-An Emerging Importance in Healthcare

Suman Kumar Ray et al.

Summary: Polyphenols, as natural plant compounds with antioxidant, antimicrobial, and anticarcinogenic activities, play a crucial role in gut ecology and human health. Their impact on intestinal biology adaptation and the two-way relationship with microbiota remains poorly understood.

FRONTIERS IN NUTRITION (2021)

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Article Biochemistry & Molecular Biology

Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line

Nora M. Aborehab et al.

Summary: Despite advances in treatment, breast cancer still has a high mortality rate among females. The study investigated the potential effects of gallic acid (GA) in the management of breast cancer, showing that the combination of GA with paclitaxel and/or carboplatin can significantly increase the expression of anti-cancer factors and promote apoptosis in breast cancer cells.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Article Oncology

Pterostilbene as a Phytochemical Compound Induces Signaling Pathways Involved in the Apoptosis and Death of Mutant P53-Breast Cancer Cell Lines

Asmaa M. Elsherbini et al.

Summary: Pterostilbene can reduce the viability and proliferation of mutant p53 breast cancer cells, promote apoptosis, and induce changes in cell morphology and protein expression. These findings demonstrate the potential anticancer effects of PT.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Review Oncology

Chemoradiotherapy in Cancer Treatment: Rationale and Clinical Applications

Kathrine S. Rallis et al.

Summary: Chemoradiotherapy (CRT) combines chemotherapy and radiotherapy as an established treatment for locally advanced solid tumors, aiming to achieve synergistic antitumor effects. Although it may cause damage to normal tissues, if the damage to tumor cells is greater, CRT is considered beneficial. Optimizing dose, timing, and fractionation of CRT is crucial for maximizing efficacy. The combination of CRT and immunotherapy is now a promising field for significant clinical benefits.

ANTICANCER RESEARCH (2021)

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Review Nutrition & Dietetics

Polyphenols and Human Health: The Role of Bioavailability

Chiara Di Lorenzo et al.

Summary: Polyphenols are a group of phytochemicals with potential health-promoting effects, classified as flavonoid and non-flavonoid molecules. Their positive effects on health are influenced by factors affecting their bioavailability, and recent studies have shown that their metabolites may have beneficial properties.

NUTRIENTS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Chemistry, Applied

Curcumin extracts from Curcuma Longa - Improvement of concentration, purity, and stability in food-approved and water-soluble surfactant-free microemulsions

Pierre Degot et al.

Summary: Curcumin was extracted from Curcuma Longa using a surfactant-free microemulsion, producing highly concentrated tinctures of up to 130 mg/mL curcuminoids. Water content influenced the extraction process and the purity of the extracts, with additional purification steps enhancing purity to 94%. Purification before extraction allowed for indefinite solubilization of water insoluble curcumin extracts in aqueous environments, with stability of the solutions for up to five months when kept away from natural light.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Effect of Resveratrol Treatment on Human Pancreatic Cancer Cells through Alterations of Bcl-2 Family Members

Katarzyna Ratajczak et al.

Summary: Resveratrol may have anticarcinogenic effects by inhibiting human pancreatic cancer cell proliferation and affecting the levels of Bcl-2 proteins. However, its activity is specific to each tested cell line, with the most significant changes observed in the mitoxantrone-resistant cells.

MOLECULES (2021)

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Article Chemistry, Medicinal

Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells

Wenbin Xu et al.

Summary: This study demonstrated that quercetin has inhibitory effects on cervical cancer cells and acts synergistically with cisplatin, enhancing the antitumor effect of cisplatin by inhibiting proliferation, migration, and invasion, and promoting apoptosis through downregulating MMP2, ezrin, METTL3, and P-Gp expression.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Article Reproductive Biology

Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis

Sifan Sun et al.

Summary: This study demonstrated that curcumin inhibits ovarian cancer cell proliferation and promotes apoptosis by regulating the circ-PLEKHM3/miR-320a/SMG1 axis. This suggests a potential therapeutic role of curcumin in ovarian cancer through mediating the circRNA/miRNA/mRNA network.

JOURNAL OF OVARIAN RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Secoisolariciresinol diglucoside induces caspase-3-mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells

Meltem Ozgocmen et al.

Summary: Research has shown that SDG can inhibit proliferation and induce apoptosis in colorectal cancer cells SW480, affecting both 2D and 3D cultures, with a significant increase in apoptotic cell percentages in the SDG treatment group.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells

Peter Thomas et al.

Summary: (-)-Epicatechin has beneficial effects in breast and prostate cancer cells by inducing apoptosis, while (+)-catechin acts as an antagonist to apoptosis induced by testosterone. Furthermore, (-)-Epicatechin activates androgen-dependent ZIP9 signaling pathways, which are typically lacking in (+)-catechin.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Antitumoral Activities of Curcumin and Recent Advances to ImProve Its Oral Bioavailability

Marta Claudia Nocito et al.

Summary: Curcumin is a phenolic compound with antimicrobial, antioxidant, anti-inflammatory and anticancer properties, but its clinical application is limited by low absorption and poor bioavailability. Various derivatives and drug delivery approaches have been developed to improve its efficacy, but further in vivo studies are needed to support its clinical applications.

BIOMEDICINES (2021)

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Review Chemistry, Medicinal

Novel Delivery Systems of Polyphenols and Their Potential Health Benefits

Bianca Enaru et al.

Summary: Liposome-based delivery systems have become increasingly popular due to their low toxicity, specificity, and ability to protect encapsulated substances. Encapsulating polyphenols in liposomes has been found to increase their bioavailability and stability, leading to more significant effects on targeted cells. This review focuses on the chemopreventive effects of polyphenols on cancer through liposomes, providing insights for future research in this area.

PHARMACEUTICALS (2021)

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Review Food Science & Technology

Food flavonols: Nutraceuticals with complex health benefits and functionalities

Davide Barreca et al.

Summary: Flavonols are bioactive compounds with health-promoting properties, including antioxidation, cardioprotection, antibacterial, antiviral, and anticancer activities. Incorporating flavonols into the human diet is highly recommended for their impressive health benefits, making them excellent nutraceuticals and ingredients for functional food. The metabolization process of flavonols also produces compounds with significant bioactivities, similar to their precursors.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Review Oncology

Mitochondrial Control of Genomic Instability in Cancer

Massimo Bonora et al.

Summary: Cancer cells display genomic instability, with mitochondria playing a key role in responding to DNA alterations and affecting cell survival and the accumulation of mutations. Mitochondrial alterations in cancer can impact cell death pathways and metabolic plasticity, contributing to the evolution of the disease. Mitochondria are involved in regulating cell death and metabolic adaptation in tumor cells, and their role in supporting genomic instability in cancer is an important aspect that warrants further exploration.

CANCERS (2021)

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Article Biochemistry & Molecular Biology

Combination of cyanidin-3-O-glucoside and cisplatin induces oxidative stress and apoptosis in HeLa cells by reducing activity of endogenous antioxidants, increasing bax/bcl-2 mRNA expression ratio, and downregulating Nrf2 expression

Xu Li et al.

Summary: The combination of C3G with DDP has shown to enhance the susceptibility of cervical cancer cells to DDP and reduce oxidative stress-induced cytotoxic effects.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Microscopy

Morphological and mechanical changes induced by quercetin in human T24 bladder cancer cells

Bruno Silveira Adami et al.

Summary: The study demonstrates that quercetin inhibits proliferation and induces apoptosis and senescence in bladder cancer cells. It also causes morphological and mechanical alterations in the cells, including decreased cell viability, cytoplasmic retraction, and membrane condensation. The findings suggest a potential anticancer effect of quercetin through its impact on cellular morphology and mechanics.

MICRON (2021)

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Article Genetics & Heredity

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

Emre Kocakavuk et al.

Summary: Ionizing radiation induces DNA damage and increases small and large deletions in tumor genomes. Effective repair of radiation-induced DNA damage is associated with worse clinical outcomes, and these genomic changes can be used to predict sensitivity to radiation therapy in recurrent cancer.

NATURE GENETICS (2021)

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Review Plant Sciences

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

Srimanta Patra et al.

Summary: Dietary polyphenols demonstrate chemopreventive activity by modulating key molecular targets and pathways to limit cancer initiation and progression. Combining polyphenols with existing anticancer drugs enhances anticancer activity and offers promising perspectives for clinical applications.

PHYTOMEDICINE (2021)

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Review Nutrition & Dietetics

Genistein: Dual Role in Women's Health

Linda Yu et al.

Summary: Genistein, a phytoestrogen found in soybeans and soya products, has shown dual effects on women's health, with potential benefits and risks depending on dosage and individual factors. Research has highlighted the importance of understanding the geographic distribution, metabolism, and bioactivity of genistein for its use as a therapeutic agent or potential endocrine disruptor in women's health.

NUTRIENTS (2021)

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Review Pharmacology & Pharmacy

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways

Manuel Humberto Chairez-Ramirez et al.

Summary: Polyphenols have been shown to regulate signaling pathways central to cancer development, progression, and metastasis. They induce protein modifications, particularly on p53, influencing its role in DNA damage response, apoptosis control, and cell-fate decisions. Understanding the effects of polyphenols on key players in cancer-driving signaling pathways can lead to improved targeted therapies with reduced toxicity for cancer treatment.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

Effects of infections on the pathogenesis of cancer

Rocco Emanuele Liardo et al.

Summary: Several studies have demonstrated an inverse relationship between acute infections and certain cancers, while chronic infections may significantly contribute to carcinogenesis. Factors increasing susceptibility to infections may include modifications of defense mechanisms, impairment of host immunity, genetic polymorphisms, aging, and malnutrition.

INDIAN JOURNAL OF MEDICAL RESEARCH (2021)

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Article Oncology

Antiproliferative, Apoptotic Effects and Suppression of Oxidative Stress of Quercetin against Induced Toxicity in Lung Cancer Cells of Rats: In vitro and In vivo Study

Zhaorigetu et al.

Summary: The study demonstrated that quercetin has good anti-proliferative activity against lung cancer cells and can induce apoptosis. Additionally, quercetin showed therapeutic effects against cyclophosphamide-induced lung toxicity.

JOURNAL OF CANCER (2021)

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Article Oncology

The Role of Polyphenol (Flavonoids) Compounds in the Treatment of Cancer Cells

Abu Hazafa et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2020)

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Review Agriculture, Multidisciplinary

Interactions of tea polyphenols with intestinal microbiota and their implication for anti-obesity

Yuan Zhao et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020)

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Article Environmental Sciences

Inhibition of urinary bladder cancer cell proliferation by silibinin

Tatiane M. B. Barros et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2020)

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Article Biochemistry & Molecular Biology

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway

Abdul Q. Khan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Pterostilbene Suppresses both Cancer Cells and Cancer Stem-Like Cells in Cervical Cancer with Superior Bioavailability to Resveratrol

Hee Jeong Shin et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Apoptosis Induced by (-)-Epicatechin in Human Breast Cancer Cells is Mediated by Reactive Oxygen Species

Fernando Pereyra-Vergara et al.

MOLECULES (2020)

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Review Chemistry, Medicinal

Apigenin as an anticancer agent

Muhammad Imran et al.

PHYTOTHERAPY RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Mariam Abotaleb et al.

BIOMOLECULES (2020)

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Article Oncology

Cyanidin 3-O-Glucoside Induces the Apoptosis in the Osteosarcoma Cells through Upregulation of the PPARγ and P21: An In Vitro Study

Hesam A. Atashi et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2020)

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Article Medicine, Research & Experimental

Ferulic Acid Induces Apoptosis of HeLa and Caski Cervical Carcinoma Cells by Down-Regulating the Phosphatidylinositol 3-Kinase (PI3K)/Akt Signaling Pathway

Liping Luo et al.

MEDICAL SCIENCE MONITOR (2020)

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Review Nutrition & Dietetics

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer

Priyanga Selvakumar et al.

NUTRIENTS (2020)

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Article Biochemistry & Molecular Biology

Pterostilbene Enhances Cytotoxicity and Chemosensitivity in Human Pancreatic Cancer Cells

Yi-Hao Hsu et al.

BIOMOLECULES (2020)

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Article Environmental Sciences

Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study

Zhixiang Xu et al.

ENVIRONMENTAL TOXICOLOGY (2020)

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Review Biochemistry & Molecular Biology

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy

Xavier Montane et al.

MOLECULES (2020)

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Article Crystallography

Structure and morphological studies of curcuminoids and curcuminoid mixture

Thimmasandra Narayan Ramesh et al.

JOURNAL OF CRYSTAL GROWTH (2020)

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Article Oncology

Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM

Joong-Seok Woo et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Food Science & Technology

The chemosensitizer ferulic acid enhances epirubicin-induced apoptosis in MDA-MB-231 cells

Wei-Jia Cheng et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

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Article Pharmacology & Pharmacy

Hesperetin Promotes Cisplatin-Induced Apoptosis of Gastric CancerIn VitroandIn Vivoby UpregulatingPTENExpression

Pengzhan He et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?

Tharindu L. Suraweera et al.

ANTIOXIDANTS (2020)

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Review Oncology

Functions of polyphenols and its anticancer properties in biomedical research: a narrative review

Pritam Bhagwan Bhosale et al.

TRANSLATIONAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol

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Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes

Gauri Deb et al.

MOLECULAR CARCINOGENESIS (2019)

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Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?

Carmen Rodriguez-Garcia et al.

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Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells

Madhumitha Kedhari Sundaram et al.

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Effects of quercetin on microRNAs: A mechanistic review

Vahid Akbari Kordkheyli et al.

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Multi-Gene Panel Testing of 23,179 Individuals for Hereditary Cancer Risk Identifies Pathogenic Variant Carriers Missed by Current Genetic Testing Guidelines

Cynthia L. Neben et al.

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Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia

Shilpa Kuttikrishnan et al.

FRONTIERS IN ONCOLOGY (2019)

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Natural Polyphenols: Chemical Classification, Definition of Classes, Subcategories, and Structures

Rajeev K. Singla et al.

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Resveratrol inhibits DHT-induced progression of prostate cancer cell line through interfering with the AR and CXCR4 pathway

Yin-Gi Jang et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

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Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial-Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine

Ran Wei et al.

NUTRIENTS (2019)

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Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

Cheol Park et al.

ANTIOXIDANTS (2019)

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Total polyphenol intake and breast cancer risk in the Seguimiento Universidad de Navarra (SUN) cohort

Itziar Gardeazabal et al.

BRITISH JOURNAL OF NUTRITION (2019)

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Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo

Yin-Chen Hsiao et al.

ENVIRONMENTAL TOXICOLOGY (2019)

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Downregulation of HDAC2 and HDAC3 via oleuropein as a potent prevention and therapeutic agent in MCF-7 breast cancer cells

Sahar Bayat et al.

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Genistein potentiates Centchroman induced antineoplasticity in breast cancer via PI3K/Akt deactivation and ROS dependent induction of apoptosis

Shweta Kaushik et al.

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Biological functions of epicatechin: Plant cell to human cell health

Monika Prakash et al.

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Flavonoids in Cancer and Apoptosis

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CANCERS (2019)

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Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

Hardeep Singh Tuli et al.

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Genistein-triggered anticancer activity against liver cancer cell line HepG2 involves ROS generation, mitochondrial apoptosis, G2/M cell cycle arrest and inhibition of cell migration

Qian Zhang et al.

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Epigallocatechin gallate (EGCG) suppresses growth and tumorigenicity in breast cancer cells by downregulation of miR-25

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Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics

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Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53-independent pathway in human lung cancer H522 cells

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JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2018)

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Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway

Cheng Gong et al.

ONCOTARGETS AND THERAPY (2018)

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Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling

Wen-Jian Hu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Cancer Prevention and Therapy with Polyphenols: Sphingolipid-Mediated Mechanisms

Michele Dei Cas et al.

NUTRIENTS (2018)

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Upregulation of microRNA 344a-3p is involved in curcumin induced apoptosis in RT4 schwannoma cells

Eun Jung Sohn et al.

CANCER CELL INTERNATIONAL (2018)

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The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

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CELL DEATH AND DIFFERENTIATION (2018)

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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?

Brandon J. Aubrey et al.

CELL DEATH AND DIFFERENTIATION (2018)

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An updated review of dietary isoflavones: Nutrition, processing, bioavailability and impacts on human health

Khalid Zaheer et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Apigenin enhances the cisplatin cytotoxic effect through p53-modulated apoptosis

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ONCOLOGY LETTERS (2017)

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A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations

Giuseppe Grosso et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

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In vitro polyphenol effects on apoptosis: An update of literature data

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SEMINARS IN CANCER BIOLOGY (2017)

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Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a

Shaofeng Mou et al.

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Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer

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Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

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In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma

Laura Masuelli et al.

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Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis

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CANCER CELL INTERNATIONAL (2017)

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Flavones: Food Sources, Bioavailability, Metabolism, and Bioactivity

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Estimated intake and major food sources of flavonoids among US adults: changes between 1999-2002 and 2007-2010 in NHANES

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EUROPEAN JOURNAL OF NUTRITION (2016)

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Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells

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Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species

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Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways

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ACS COMBINATORIAL SCIENCE (2016)

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Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling

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Pterostilbene inhibits hepatocellular carcinoma through p53/SOD2/ROS-mediated mitochondrial apoptosis

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Quercetin induces caspase-dependent extrinsic apoptosis through inhibition of signal transducer and activator of transcription 3 signaling in HER2-overexpressing BT-474 breast cancer cells

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis

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CANCER CELL INTERNATIONAL (2015)

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Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species

Jixiang Zhang et al.

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Cyanidin induces apoptosis and differentiation in prostate cancer cells

Valeria Sorrenti et al.

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Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

Shreyasi Palit et al.

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Quercetin induces the apoptosis of human ovarian carcinoma cells by upregulating the expression of microRNA-145

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Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-κB-p53-caspase-3 pathway

Yu-Ping Dang et al.

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Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70-Bax interaction in prostate cancer

Sanjeev Shukla et al.

APOPTOSIS (2014)

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Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling

Yingzhuan Zhan et al.

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The TRAIL Sensitization Effect of Substituted Triazolyl Curcumin Mimics Against Brain Cancer Cells

Daeho Kwon et al.

BULLETIN OF THE KOREAN CHEMICAL SOCIETY (2014)

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A comprehensive review on flavanones, the major citrus polyphenols

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Genistein inhibits the proliferation and differentiation of MCF-7 and 3T3-L1 cells via the regulation of ERα expression and induction of apoptosis

Eun Jeong Choi et al.

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MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells

Teng Yu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

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Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone

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The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways

Ali A. Alshatwi et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2013)

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Inhibition of the PI3K/AKT-NF-κB Pathway With Curcumin Enhanced Radiation-Induced Apoptosis in Human Burkitt's Lymphoma

Qiao Qiao et al.

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Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins

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Curcumin induces FasL-related apoptosis through p38 activation in human hepatocellular carcinoma Huh7 cells

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Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway

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TRENDS IN CELL BIOLOGY (2013)

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Apigenin induces apoptosis via tumor necrosis factor receptor- and Bcl-2-mediated pathway and enhances susceptibility of head and neck squamous cell carcinoma to 5-fluorouracil and cisplatin

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

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Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line - A comparative study

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FOOD AND CHEMICAL TOXICOLOGY (2012)

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Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells

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ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2011)

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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)

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Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species

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MOLECULAR NUTRITION & FOOD RESEARCH (2011)

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Synergistic Effects of Apigenin and Paclitaxel on Apoptosis of Cancer Cells

Yimiao Xu et al.

PLOS ONE (2011)

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Quercetin-mediated Cell Cycle Arrest and Apoptosis Involving Activation of a Caspase Cascade through the Mitochondria! Pathway in Human Breast Cancer MCF-7 Cells

Chu-Chung Chou et al.

ARCHIVES OF PHARMACAL RESEARCH (2010)

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Bioavailability of the Polyphenols: Status and Controversies

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Pterostilbene Inhibits Breast Cancer In Vitro Through Mitochondrial Depolarization and Induction of Caspase-Dependent Apoptosis

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JOURNAL OF SURGICAL RESEARCH (2010)

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Flaxseed and Pure Secoisolariciresinol Diglucoside, but Not Flaxseed Hull, Reduce Human Breast Tumor Growth (MCF-7) in Athymic Mice

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JOURNAL OF NUTRITION (2009)

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Curcumin inhibits NFκB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells

Natarajan Aravindan et al.

CANCER BIOLOGY & THERAPY (2008)

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Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis

Sharmila Shankar et al.

MOLECULAR CANCER (2008)

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Caspases in apoptosis and beyond

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Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB

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Journal of Ovarian Research (2008)

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Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

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Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation

Eun Mi Jung et al.

CARCINOGENESIS (2006)

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Apoptosis and genomic instability

B Zhivotovsky et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

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From polyploidy to aneuploidy, genome instability and cancer

Z Storchova et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)

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Mitochondria damage checkpoint in apoptosis and genome stability

KK Singh

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Control of apoptosis by p53

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ONCOGENE (2003)

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Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

A Konishi et al.

CELL (2003)

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Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction

T Choudhuri et al.

FEBS LETTERS (2002)

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Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53

JA Bush et al.

EXPERIMENTAL CELL RESEARCH (2001)

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The age of cancer

RA DePinho

NATURE (2000)

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The biochemistry of apoptosis

MO Hengartner

NATURE (2000)

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The Bcl-2 protein family

B Antonsson et al.

EXPERIMENTAL CELL RESEARCH (2000)

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Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

AJ Day et al.

FEBS LETTERS (2000)

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The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

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