Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms232214051
Keywords
pancreatic progenitors; Sox9; FAD; PLP; transcription factor; Sox family
Funding
- Qatar National Research Fund [NPRP11S-0120-180346]
- Qatar Biomedical Research Institute
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This study demonstrates that the cofactors FAD and PLP interact with Sox9 to induce an increase in pancreatic development markers, revealing the mechanism underlying their involvement in pancreas development.
Cofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B-2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic development, including Ngn3 and PTF1a. Pyridoxal 5 '-phosphate (PLP), the active form of vitamin B-6, also binds to Sox9 and results in a similar increase in pancreatic development markers. Sox9 is known to be specifically important for pancreatic progenitors. Previously, there was no known link between FAD, PLP, or other co-factors and Sox9 for function. Thus, our findings show the mechanism by which FAD and PLP interact with Sox9 and result in the altered expression of pancreatic progenitor transcription factors involved in the pancreas development.
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