Comment on Yoo et al. Amylin Protein Expression in the Rat Brain and Neuro-2a Cells. Int. J. Mol. Sci. 2022, 23, 4348

Article Multidisciplinary Sciences

Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice

Kansai Fukumitsu et al.

Summary: Social animals experience stress upon isolation and actively engage in contact with conspecifics. This study demonstrates that amylin-calcitonin receptor signaling in the medial preoptic area mediates affiliative social contacts among adult female mice. Isolation leads to active contact-seeking behavior and depressive-like behavior, along with a decrease in Amylin mRNA expression. Reuniting with peers induces physical contacts and a recovery of Amylin mRNA expression.

NATURE COMMUNICATIONS (2022)

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Article Biochemistry & Molecular Biology

Amylin Protein Expression in the Rat Brain and Neuro-2a Cells

Yeong-Min Yoo et al.

Summary: This study investigated the expression distribution of amylin protein in the rat brain and N2a cells, and found that progesterone and dexamethasone influence the expression of amylin protein.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Physiology

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

Tayla A. Rees et al.

Summary: This study identified the relative distributions of the AMY(1) receptor subunit, CTR, and CGRP in neurons or glia in the trigeminal ganglia of rats, mice, and humans. It was found that CTR and CGRP were primarily colocalized in small to medium sized neurons, suggesting a role for CTR-based receptor activation during migraine. The results suggest that targeting the trigeminal ganglia CTR-based receptor could be a potential treatment for craniofacial pain and migraine.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Physiology

Amylin antibodies frequently display cross-reactivity with CGRP: characterization of eight amylin antibodies

Tayla A. Rees et al.

Summary: This study found that current amylin antibodies frequently cross-react with CGRP, making them unsuitable for use in tissues that highly express CGRP. Therefore, previous studies using these antibodies should be reevaluated in light of these findings.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2021)

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Article Clinical Neurology

Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients

Hashmat Ghanizada et al.

Summary: This study investigated the role of pramlintide in the pathogenesis of migraine, finding that it participates in migraine attacks through activation of the amylin receptor. Through experiments on patients and studies on animal models, it was discovered that pramlintide and CGRP have similar effects in inducing migraine-like symptoms.

ANNALS OF NEUROLOGY (2021)

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Article Cell Biology

Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care

Chihiro Yoshihara et al.

Summary: Maternal mammals exhibit heightened motivation to care for offspring, and this behavior is at least partially mediated by upregulation of amylin-Calcr signaling in distinct neuronal populations of the medial preoptic area. These Calcr+ MPOA neurons are required for both maternal and allomaternal nurturing behaviors, with modified connectomics postpartum potentially influencing risk-taking maternal care.

CELL REPORTS (2021)

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Review Clinical Neurology