4.7 Article

Use of Hierarchical Carbon Nanofibers Decorated with NiCo Nanoparticles for Highly Sensitive Vortioxetine Determination

Journal

Publisher

MDPI
DOI: 10.3390/ijms232314555

Keywords

vortioxetine; electrode modifier; voltammetry; carbon nanofibers; nanoparticles

Ask authors/readers for more resources

A new voltammetry method using modified carbon nanofibers with NiCo nanoparticles as electrodes was developed for highly sensitive detection of the antidepressant drug vortioxetine. The electrochemical behavior and various influencing factors of vortioxetine were investigated, and a linear voltametric response was obtained in a concentration range with a low detection limit. The proposed method was successfully applied in the analysis of complex matrices such as tablets, urine, and plasma.
A new voltammetry method for the highly sensitive antidepressant drug vortioxetine (VOR) is presented using glassy carbon electrodes modified with hierarchical carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo-GCE). The electrochemical behavior of VOR was investigated by cyclic voltammetry, which indicates that its oxidation is an adsorption-controlled process with the exchange of two electrons and one proton. The effects of various factors on the VOR peak, such as supporting electrolyte type, preconcentration time, and potential, or influence of interferents, were tested using the square wave voltammetry technique (SWV). The linear voltametric response for the analyte was obtained in the concentration range from 0.01 center dot 10(-6) to 3.0 center dot 10(-6) mol L-1 with the detection limit of 1.55 center dot 10(-9) mol L-1 for a preconcentration time of 60 s. The proposed method was successfully applied for highly sensitive VOR determination in complex matrices such as tablets, urine, and plasma with good recovery parameter.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available