Novel Approaches in Molecular Imaging and Neuroimaging of Fibromyalgia

Fibromyalgia (FM) represents a condition that is still controversial in its entity, pathophysiology, diagnosis and management. The aim of this review is to focus on imaging aspects of FM, especially on novel approaches in molecular imaging, with a special focus on neuroimaging. Novel functional and molecular imaging findings may represent, eventually, future biomarkers both in research settings and in terms of clinical practice. Several imaging techniques have already been tested in clinical trials in the FM field, including functional MRI, positron emission tomography (PET) imaging with F-18-FDG in FM, PET imaging of the dopaminergic system, PET imaging of the GABAergic system, PET imaging with neuroinflammation and neuroimmune parameters, PET imaging of the opioid system and (H2O)-O-15-PET activation studies. Therefore, the potential role in the FM field of fMRI and different PET tracers has been discussed in different settings, serving as a comprehensive guide of novel imaging options both in research and in the clinical field.

Automated summary

This review focuses on imaging aspects of fibromyalgia, particularly novel approaches in molecular imaging, with an emphasis on neuroimaging. The potential role of functional MRI and different PET tracers in the field of fibromyalgia has been discussed, serving as a comprehensive guide for novel imaging options in research and clinical settings.