4.7 Review

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Value of C-11 methionine PET/CT in patients with intracranial germinoma

Yong-Jin Park et al.

Summary: The study aimed to investigate the value of C-11 methionine positron emission tomography/computed tomography (MET PET/CT) in patients with intracranial germinoma (IG). The findings showed that MET PET/CT could be a useful diagnostic tool for IGs and that tumor MET avidity may serve as a potential surrogate biomarker for HCG.

PLOS ONE (2022)

Article Multidisciplinary Sciences

Maximum 11C-methionine PET uptake as a prognostic imaging biomarker for newly diagnosed and untreated astrocytic glioma

Kosuke Nakajo et al.

Summary: This study aimed to investigate whether 11C-methionine PET can be used as an additional imaging biomarker to estimate the prognosis of glioma. The study found that LN max may serve as a prognostic marker for newly diagnosed and untreated WHO grade II-IV astrocytic glioma.

SCIENTIFIC REPORTS (2022)

Review Cell Biology

Imaging Approaches for the Study of Metabolism in Real Time Using Genetically Encoded Reporters

Panagiotis Chandris et al.

Summary: This article provides an overview of available tools for monitoring the dynamics of biochemical reactions and the kinetics of metabolites, and discusses the potential for developing new methodologies that combine classical biochemistry with advanced imaging.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

First-in-Human PET Imaging and Estimated Radiation Dosimetry of L-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer

Allison S. Cohen et al.

Summary: PET imaging using C-11-glutamine is safe and effective for noninvasively visualizing metastatic colon cancer lesions in multiple organs, providing potential utility for cancer imaging and monitoring treatment response.

JOURNAL OF NUCLEAR MEDICINE (2022)

Review Biochemistry & Molecular Biology

Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade

George Crisan et al.

Summary: Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are imaging techniques that use radioactive tracers. PET is mainly used for measuring metabolic processes, blood flow, and chemical composition, while SPECT is used for diagnosing conditions such as strokes, bone diseases, and infections. This article provides a systematic review of the scientific literature on PET/SPECT radiotracers and gives an overview of the research conducted in the past decade, with a focus on novel radiopharmaceuticals for medical imaging.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Gastroenterology & Hepatology

Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer

Zhijun Zhou et al.

Summary: In this study, we found that ACSS2 enhances nonselective macropinocytosis and muscle wasting in pancreatic cancer through metabolic reprogramming, revealing the potential mechanism behind these processes.

GASTROENTEROLOGY (2022)

Review Nanoscience & Nanotechnology

Update on the Use of PET/MRI Contrast Agents and Tracers in Brain Oncology: A Systematic Review

Alessio Smeraldo et al.

Summary: Hybrid PET/MRI is a promising diagnostic tool for the early diagnosis, staging, and recurrence of brain diseases. However, a better definition of the role of tracers and imaging agents in both clinical and preclinical applications is needed, and efforts should be made to standardize contrast imaging protocols.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

Review Oncology

Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism

Mengfang Liu et al.

Summary: Acetyl-CoA Synthetase 2 (ACSS2) is highly expressed in various tumors and plays an important role in tumor growth, proliferation, invasion, and metastasis under nutritional stress. ACSS2 inhibitors have shown effectiveness in halting cancer growth and can be used in combination with other antineoplastic drugs to reduce drug resistance. This article reviews the mechanisms of ACSS2-promoting tumor growth and the potential clinical application of targeted inhibitors.

CANCERS (2022)

Review Oncology

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development

Rui Ling et al.

Summary: ACSS2, a member of the ACSS family, plays a crucial role in material energy metabolism, acetylation regulation, and tumorigenesis.

DISCOVER ONCOLOGY (2022)

Article Chemistry, Medicinal

A new concept for the production of 11C-labelled radiotracers

Jan Wenz et al.

Summary: This study described a novel single use unit for the synthesis of carbon-11 labelled tracers for preclinical and clinical applications, including N-methyl-[C-11]choline, L-S-methyl-[C-11]methionine, and [C-11]acetate.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

MR imaging by 3D T1-weighted black blood sequences may improve delineation of therapy-naive high-grade gliomas

Tom Finck et al.

Summary: The study suggests that CE BB imaging can significantly improve the delineation of therapy-naive HGGs compared to traditional TFE imaging, indicating a potential supplementary role for CE BB sequences in MRI protocols for brain tumors.

EUROPEAN RADIOLOGY (2021)

Article Neurosciences

Role of contrast-enhanced FLAIR MRI in diagnosis of intracranial lesions

Wessam Mustafa et al.

Summary: The study demonstrates that CE-FLAIR sequence shows superior enhancement in diagnosing various intracranial pathological conditions and has a higher level of lesion conspicuity. The results also indicate a significant difference in signal intensity and contrast-to-background ratio between CE-FLAIR images and post-contrast T1 images.

EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors

Yoichi Shimizu et al.

Summary: This study found that MRP1 inhibitors can increase [F-18]FMISO accumulation in hypoxic cells, indicating that the [F-18]FMISO-PET imaging is affected by MRP1 inhibitors independent of the hypoxic state.

EJNMMI RESEARCH (2021)

Review Cell Biology

Metabolism of Amino Acids in Cancer

Zhen Wei et al.

Summary: Metabolic reprogramming involving amino acid metabolism is a recognized hallmark of malignancy, with potential therapeutic implications in targeting this pathway for cancer treatment. Amino acids play a crucial role in supporting survival and proliferation of cancer cells under various stress conditions.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

Comparing the diagnostic performance of radiotracers in recurrent prostate cancer: a systematic review and network meta-analysis

Ian Leigh Alberts et al.

Summary: A study compared the detection rate of different radiotracers for recurrent prostate cancer, revealing similar performance among PSMA radiotracers except for 18F-PSMA-1007, which showed clear superiority over choline tracers. The majority of studies were found to have risk of publication bias, indicating a need for more robust evidence synthesis in guiding evidence-based decisions in radiotracer selection.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

Article Medicine, Research & Experimental

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

Deanna N. Edwards et al.

Summary: Research shows an inverse correlation between glutamine metabolic genes and markers of T cell-mediated cytotoxicity in basal-like breast cancer patients, with increased glutamine metabolism associated with poor survival. Targeting glutamine metabolism selectively in tumors may be a promising therapeutic strategy for improving antitumor immune responses.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Medicine, General & Internal

Initial Institutional Experience with 18F-Fluciclovine PET-CT in Biochemical Recurrence of Prostate Cancer

Amy B. Farkas et al.

Summary: The study investigates the institutional experience with 18F-fluciclovine PET-CT in evaluating prostate cancer with biochemical recurrence. The results show a high positivity rate, with fluciclovine helping to detect early recurrent disease and guide clinical management effectively.

SOUTHERN MEDICAL JOURNAL (2021)

Article Oncology

Metabolic adaptation in hypoxia and cancer

Felipe Paredes et al.

Summary: The focus of cells' adaptation to hypoxia is the transcription factor HIF1α, which promotes tumor development by affecting cellular metabolism. In addition to hypoxia, metabolic inhibition also influences HIF1α stability and activity, promoting glycolytic metabolism in cancer cells to support growth and proliferation.

CANCER LETTERS (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

A retrospective analysis of the diagnostic performance of 11C-choline PET/CT for detection of hyperfunctioning parathyroid glands after prior negative or discordant imaging in primary hyperparathyroidism

M. E. Noltes et al.

Summary: This study investigated the diagnostic performance of C-11-choline PET/CT in patients with pHPT after prior negative or discordant imaging. The results showed that C-11-choline PET/CT had a per-lesion sensitivity of 97%, a positive predictive value of 95% and an accuracy of 94%. In patients with pHPT and prior negative or discordant first-line imaging results, C-11-choline PET/CT can accurately and sensitively localize pathological parathyroid glands.

EJNMMI RESEARCH (2021)

Article Biology

Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes

Zhongying Wang et al.

Summary: In Type 2 diabetes, there are differential usages of oxidative phosphorylation and glycolysis in living islet cells following glucose stimulation, as revealed by phasor-FLIM. This study suggests the potential applicability of FLIM as a sensitive tool for drug discovery in diabetes by reporting perturbations in glucose metabolism in living islet cells.

COMMUNICATIONS BIOLOGY (2021)

Article Cell Biology

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

Ramon C. Sun et al.

Summary: This study demonstrates the connection between N-linked protein glycosylation and glucosamine metabolism in the brain, where glucosamine acts as an abundant constituent of brain glycogen for glycoconjugates. The enzymatic mechanisms of glucosamine incorporation and release in glycogen were validated, revealing that disruption of brain glycogen metabolism leads to decreased levels of UDP-N-acetylglucosamine and N-linked protein glycosylation.

CELL METABOLISM (2021)

Review Biochemistry & Molecular Biology

Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect

So-Hee Kim et al.

Summary: Cancer is characterized by abnormal cell growth and proliferation, with the Warburg effect playing a significant role in the metabolic processes of cancer cells. Various signaling factors regulate the glycolysis pathway in cancer cells through the ubiquitin-proteasome system, and DUBs can act as both oncogenes and tumor suppressors depending on the target protein. Targeting DUBs and their inhibitors associated with the Warburg effect may hold promise as potential anticancer strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer

Chang Liu et al.

Summary: This review discusses the role of glycolysis in chemoresistance, exploring the mechanisms from glycolysis processes, signaling pathways, tumor microenvironment, and their interactions. Understanding how glycolysis induces chemoresistance may offer new molecular targets and concepts for cancer therapy.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

Window of opportunity clinical trial designs to study cancer metabolism

Francesca Aroldi et al.

BRITISH JOURNAL OF CANCER (2020)

Review Oncology

Reprogramming of fatty acid metabolism in cancer

Nikos Koundouros et al.

BRITISH JOURNAL OF CANCER (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Clinical translation of 18F-fluoropivalate - a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers

Suraiya R. Dubash et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)

Review Biochemistry & Molecular Biology

Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets

Nerea Gandoy-Fieiras et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Glutamine reliance in cell metabolism

Hee Chan Yoo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Radiology, Nuclear Medicine & Medical Imaging

Role of Non-FDG-PET/CT in Head and Neck Cancer

Charles Marcus et al.

SEMINARS IN NUCLEAR MEDICINE (2020)

Article Physiology

Monte Carlo Simulations of the GE Signa PET/MR for Different Radioisotopes

Paulo R. R. V. Caribe et al.

FRONTIERS IN PHYSIOLOGY (2020)

Article Chemistry, Medicinal

Development of a fluorine-18 radiolabelled fluorescent chalcone: evaluated for detecting glycogen

Louis Allott et al.

EJNMMI RADIOPHARMACY AND CHEMISTRY (2020)

Review Chemistry, Medicinal

[Ga-68]Ga-DOTA-TOC: The First FDA-Approved Ga-68-Radiopharmaceutical for PET Imaging

Ute Hennrich et al.

PHARMACEUTICALS (2020)

Review Chemistry, Multidisciplinary

Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N-, and 15O-Labeling Reactions

Xiaoyun Deng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Cell Biology

Metabolic regulation of cell growth and proliferation

Jiajun Zhu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Cell Biology

Acetate Metabolism in Physiology, Cancer, and Beyond

Shree Bose et al.

TRENDS IN CELL BIOLOGY (2019)

Review Medicine, General & Internal

The Roles of Hypoxia Imaging Using 18F-Fluoromisonidazole Positron Emission Tomography in Glioma Treatment

Kenji Hirata et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Karen G. de la Cruz-Lopez et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Sydney M. Sanderson et al.

NATURE REVIEWS CANCER (2019)

Review Oncology

The Metabolic Interplay between Cancer and Other Diseases

Anne Le et al.

TRENDS IN CANCER (2019)

Review Biochemistry & Molecular Biology

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

Pierre-Benoit Ancey et al.

FEBS JOURNAL (2018)

Article Oncology

C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Postoperative Residual Disease and Response to Chemoradiation Therapy

Yingbing Wang et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

Article Chemistry, Analytical

One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

A. M. Senisik et al.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY (2018)

Review Medicine, General & Internal

Positron Emission Tomography in the Diagnosis and Management of Coronary Artery Disease

Egle Kazakauskaite et al.

MEDICINA-LITHUANIA (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine

Mark P. S. Dunphy et al.

RADIOLOGY (2018)

Review Medicine, General & Internal

Positron Emission Tomography in the Diagnosis and Management of Coronary Artery Disease

Egle Kazakauskaite et al.

MEDICINA-LITHUANIA (2018)

Review Chemistry, Multidisciplinary

Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors

Aixia Sun et al.

FRONTIERS IN CHEMISTRY (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

T1-weighted parenchyma attenuated inversion recovery: A novel sequence that improves contrast ratio of enhancing brain lesions

A. Batouli et al.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts

Victoria R. Pell et al.

CURRENT CARDIOVASCULAR IMAGING REPORTS (2018)

Article Biology

Cell Synchronization by Double Thymidine Block

Guo Chen et al.

BIO-PROTOCOL (2018)

Article Radiology, Nuclear Medicine & Medical Imaging

Quantitative [18F]FMISO PET Imaging Shows Reduction of Hypoxia Following Trastuzumab in a Murine Model of HER2+Breast Cancer

Anna G. Sorace et al.

MOLECULAR IMAGING AND BIOLOGY (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

[18F]Fluorocholine PET/CT Imaging of Liver Cancer: Radiopathologic Correlation with Tissue Phospholipid Profiling

Sandi A. Kwee et al.

MOLECULAR IMAGING AND BIOLOGY (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

11C-methionine PET/CT findings in benign brain disease

Reiko Nakajima et al.

JAPANESE JOURNAL OF RADIOLOGY (2017)

Article Biochemistry & Molecular Biology

Fibulin-3 promotes muscle-invasive bladder cancer

A. L. Han et al.

ONCOGENE (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

11C-methionine PET/CT findings in benign brain disease

Reiko Nakajima et al.

JAPANESE JOURNAL OF RADIOLOGY (2017)

Article Endocrinology & Metabolism

Primary hyperparathyroidism caused by enormous unilateral water-clear cell parathyroid hyperplasia

Georgios Boutzios et al.

BMC ENDOCRINE DISORDERS (2017)

Article Oncology

18F-Fluoromisonidazole in tumor hypoxia imaging

Zuoyu Xu et al.

ONCOTARGET (2017)

Review Biochemistry & Molecular Biology

Targeting Metabolism for Cancer Therapy

Alba Luengo et al.

CELL CHEMICAL BIOLOGY (2017)

Article Cell Biology

A pathway map of glutamate metabolism

Soujanya D. Yelamanchi et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of Prostate Cancer with 11C-Acetate PET/CT

Claudio Spick et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Importance of Contrast-Enhanced Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging in Various Intracranial Pathologic Conditions

Eun Kyoung Lee et al.

KOREAN JOURNAL OF RADIOLOGY (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

2-[18F]fluoro-2-deoxy-D-galactose PET/CT of hepatocellular carcinoma is not improved by co-administration of galactose

Kirstine P. Bak-Fredslund et al.

NUCLEAR MEDICINE AND BIOLOGY (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

11C-Choline PET/CT in Recurrent Prostate Cancer and Nonprostatic Neoplastic Processes

Christopher L. Welle et al.

RADIOGRAPHICS (2016)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Malignancies with Low Fluoro-deoxyglucose Uptake at PET/CT: Pitfalls and Prognostic Importance

Robert R. Flavell et al.

RADIOGRAPHICS (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

Optimal 2-[18F]fluoro-2-deoxy-D-galactose PET/CT protocol for detection of hepatocellular carcinoma

Jacob Horsager et al.

EJNMMI RESEARCH (2016)

Review Oncology

The metabolic fate of acetate in cancer

Zachary T. Schug et al.

NATURE REVIEWS CANCER (2016)

Review Engineering, Biomedical

Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

Juan Jose Vaquero et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 17 (2015)

Review Cell Biology

Metabolic pathways promoting cancer cell survival and growth

Lindsey K. Boroughs et al.

NATURE CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

Emelyn H. Shroff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell Biology

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

Sriram Venneti et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Radiology, Nuclear Medicine & Medical Imaging

F-18 Fluoromisonidazole for Imaging Tumor Hypoxia: Imaging the Microenvironment for Personalized Cancer Therapy

Joseph G. Rajendran et al.

SEMINARS IN NUCLEAR MEDICINE (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

Diagnosis of pseudoprogression in patients with glioblastoma using O-(2-[18F]fluoroethyl)-L-tyrosine PET

Norbert Galldiks et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0

Ronald Boellaard et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

Review Biotechnology & Applied Microbiology

Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey

Robert M. Hoffman

EXPERT OPINION ON BIOLOGICAL THERAPY (2015)

Review Oncology

Glycosylation in cancer: mechanisms and clinical implications

Salome S. Pinho et al.

NATURE REVIEWS CANCER (2015)

Review Endocrinology & Metabolism

Role of 18F-FDOPA PET/CT imaging in endocrinology

Prasanna Santhanam et al.

CLINICAL ENDOCRINOLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Tumor hypoxia and microscopic diffusion capacity in brain tumors: A comparison of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging

Ayako Hino-Shishikura et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2014)

Review Oncology

Positron Emission Tomography (PET) in Oncology

Andrea Gallamini et al.

CANCERS (2014)

Review Radiology, Nuclear Medicine & Medical Imaging

Value of 11C-methionine PET in imaging brain tumours and metastases

Andor W. J. M. Glaudemans et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2013)

Review Medicine, Research & Experimental

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Christopher T. Hensley et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Neurosciences

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

William A. Flavahan et al.

NATURE NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Limits of [18F]-FLT PET as a Biomarker of Proliferation in Oncology

Eliot T. McKinley et al.

PLOS ONE (2013)

Article Cardiac & Cardiovascular Systems

A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function

Janis Kuka et al.

CARDIOVASCULAR TOXICOLOGY (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis

Giorgio Treglia et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2012)

Review Radiology, Nuclear Medicine & Medical Imaging

Performance of 18F-Fluoro-Ethyl-Tyrosine (18F-FET) PET for the Differential Diagnosis of Primary Brain Tumor: A Systematic Review and Metaanalysis

Vincent Dunet et al.

JOURNAL OF NUCLEAR MEDICINE (2012)

Review Medicine, Research & Experimental

Clinical Indications of 11C-Choline PET/CT in Prostate Cancer Patients with Biochemical Relapse

Maria Picchio et al.

THERANOSTICS (2012)

Review Cell Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Sophia Y. Lunt et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

The potential use of 2-[18F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma

Michael Sorensen et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2011)

Review Biochemistry & Molecular Biology

Thymidine Analogues for Tracking DNA Synthesis

Brenton L. Cavanagh et al.

MOLECULES (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

Nucleophilic radiosynthesis of 2-[18F]fluoro-2-deoxy-D-galactose from Talose triflate and biodistribution in a porcine model

Kim Frisch et al.

NUCLEAR MEDICINE AND BIOLOGY (2011)

Article Radiology, Nuclear Medicine & Medical Imaging

PET/CT Imaging and Radioimmunotherapy of Prostate Cancer

Kirsten Bouchelouche et al.

SEMINARS IN NUCLEAR MEDICINE (2011)

Review Microbiology

Nitroaromatic Compounds, from Synthesis to Biodegradation

Kou-San Ju et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2010)

Article Radiology, Nuclear Medicine & Medical Imaging

Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma

Yukie Yoshii et al.

NUCLEAR MEDICINE AND BIOLOGY (2010)

Article Biochemical Research Methods

A Novel Method for Direct Site-Specific Radiolabeling of Peptides Using [18F]FDG

Mohammad Namavari et al.

BIOCONJUGATE CHEMISTRY (2009)

Article Gastroenterology & Hepatology

Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F] fluoro-2-deoxygalactose positron emission tomography

Michael Sorensen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer

Corinna von Forstner et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

6-L-F-18-fluorodihydroxyphenylalanine PET in neuroendocrine tumors: Basic aspects and emerging clinical applications

Pieter L. Jager et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

A Prospective Evaluation of 18F-FDG and 11C-Acetate PET/CT for Detection of Primary and Metastatic Hepatocellular Carcinoma

Joong-Won Park et al.

JOURNAL OF NUCLEAR MEDICINE (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

The detection rate of [C-11]Choline-PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer

B. J. Krause et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2008)

Article Gastroenterology & Hepatology

Lectin-reactive α-fetoprotein in patients with tyrosinemia type I and hepatocellular carcinoma

Ulrich Baumann et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2006)

Article Medicine, General & Internal

Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer

T Andre et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Review Oncology

5-Fluorouracil: Mechanisms of action and clinical strategies

DB Longley et al.

NATURE REVIEWS CANCER (2003)

Review Pharmacology & Pharmacy

Pivalate-generating Prodrugs and carnitine homeostasis in man

EP Brass

PHARMACOLOGICAL REVIEWS (2002)