A Proof-of-Concept Analysis of Plasma-Derived Exosomal microRNAs in Interstitial Pulmonary Fibrosis Secondary to Antisynthetase Syndrome

Article Pharmacology & Pharmacy

miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy

Xiao-xu Yang et al.

Summary: This study found that miR-30a-5p plays an inhibitory role in cardiac fibrosis in diabetic cardiomyopathy by reducing the expression of Smad2. This finding provides new insights for the research and treatment of diabetic cardiomyopathy.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

MicroRNA-30a-5p silencing polarizes macrophages toward M2 phenotype to alleviate cardiac injury following viral myocarditis by targeting SOCS1

Yan Zhang et al.

Summary: In this study, it was discovered that inhibition of miR-30a-5p may improve cardiac injury following viral myocarditis by promoting M2 polarization of macrophages via SOCS1 upregulation. The anti-inflammatory mechanisms of miR-30a-5p inhibition could potentially lead to the development of new therapeutic strategies for viral myocarditis.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MiR-30a-5p ameliorates LPS-induced inflammatory injury in human A549 cells and mice via targeting RUNX2

Pibao Li et al.

Summary: In this study, miR-30a-5p was found to ameliorate LPS-induced inflammatory injury in A549 cells and mice by targeting RUNX2 and related signaling pathways, thereby influencing the progression of ARDS.

INNATE IMMUNITY (2021)

Add to Collection

Article Immunology

MiRNA-29c-3p Promotes Intestinal Inflammation via Targeting Leukemia Inhibitory Factor in Ulcerative Colitis

Jian Guo et al.

Summary: The study found that miR-29c-3p was significantly downregulated in UC patients and experimental colitis mice, while LIF was upregulated. By suppressing LIF, miR-29c-3p promotes gut inflammation and modulates the pathogenesis of UC.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Add to Collection

Article Medicine, Research & Experimental

A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity

Chin-Cheng Lee et al.

Summary: Through analysis, CD276 was identified as a risk gene in several cancers, showing a positive correlation with NK cell infiltration. Overexpression of miR-29c-3p restored CD276-reduced NK cell cytotoxicity. The negative regulatory loop involving CD276, Myc, and miR-29c-3p plays a significant role in influencing cancer cells against NK cell cytotoxicity.

LIFE SCIENCES (2021)

Add to Collection

Article Cell Biology

MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development

Rupa Kumari et al.

Summary: The study showed that miR-29c regulates RAG1 in a B cell stage-specific manner, modulation of miR-29c levels affects V(D)J recombination efficiency in pre-B cells, and a negative correlation between miR-29c and RAG1 levels is observed in different developmental stages.

CELL REPORTS (2021)

Add to Collection

Article Medicine, General & Internal

Fer exacerbates renal fibrosis and can be targeted by miR-29c-3p

Chen-Min Sun et al.

Summary: The study revealed that dysregulation of miR-29c-3p and Fer plays a crucial role in RF, suggesting that inhibiting Fer could be a potential treatment for RF.

OPEN MEDICINE (2021)

Add to Collection

Article Medicine, Research & Experimental

Clinical value and role of microRNA-29c-3p in sepsis-induced inflammation and cardiac dysfunction

Bingyu Zhang et al.

Summary: This study found that miR-29c-3p is upregulated in sepsis patients and can distinguish sepsis patients from healthy controls. In a rat sepsis model, cardiac dysfunction and inflammation were observed, but these effects were reversed by injecting miR-29c-3p antagomir. Logistic regression analysis indicated that miR-29c-3p is an independent factor in the occurrence of cardiac dysfunction in sepsis patients.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology