Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms232214253
Keywords
transient receptor potential; tumor vascularization; endothelial cells; endothelial colony-forming cells; Ca2+ signaling
Funding
- Ph.D program of University of Campania Luigi Vanvitelli, Naples, Italy
- University of Campania Luigi Vanvitelli
- University of Molise
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Tumor diseases spread quickly and studies have focused on the role of ion channels, particularly the Transient Receptor Potential (TRP) channels, in tumor vessel formation.
Tumor diseases are unfortunately quick spreading, even though numerous studies are under way to improve early diagnosis and targeted treatments that take into account both the different characteristics associated with the various tumor types and the conditions of individual patients. In recent years, studies have focused on the role of ion channels in tumor development, as these proteins are involved in several cellular processes relevant to neoplastic transformation. Among all ion channels, many studies have focused on the superfamily of Transient Receptor Potential (TRP) channels, which are non-selective cation channels mediating extracellular Ca2+ influx. In this review, we examined the role of different endothelial TRP channel isoforms in tumor vessel formation, a process that is essential in tumor growth and metastasis.
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