Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 24, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms24010037
Keywords
miRNA-30c; autophagy; inflammation; ER stress; thrombosis; neurological disorders; stroke; oxidative stress
Ask authors/readers for more resources
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that negatively regulate gene expression by interacting with target mRNAs. The miR-30 family, including miR-30c, plays a role in tissue development and is implicated in neurological disorders. miR-30c may act as a multi-functional regulator in autophagy, apoptosis, stress response, inflammation, thrombosis, and neurovascular function, contributing to different disease states.
MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3 ' untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of many tissues and organs and participate in the pathogenesis of human diseases. As a key member of the miR-30 family, miR-30c has been implicated in neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. Mechanistically, miR-30c may act as a multi-functional regulator of different pathogenic processes such as autophagy, apoptosis, endoplasmic reticulum stress, inflammation, oxidative stress, thrombosis, and neurovascular function, thereby contributing to different disease states. Here, we review and discuss the biogenesis, gene regulation, and the role and mechanisms of action of miR-30c in several neurological disorders and therapeutic potential in clinics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available