Journal
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
Volume 52, Issue 6, Pages 595-599Publisher
WILEY
DOI: 10.1111/jpc.13214
Keywords
critically ill children; Down syndrome; mortality
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AimTo investigate clinical course and mortality-associated factors in children with Down syndrome (DS) managed in a medical paediatric intensive care unit. MethodsA single-centre, retrospective study conducted between 2001 and 2010 in DS children aged 1month to 16years. ResultsSixty-six patients with a median age of 24months (1-192) and a male/female ratio of 1.5 were analysed. Patients presented with history of congenital heart disease (n=52, 78.8%), mechanical ventilation (n=40, 60.6%) and chronic upper airway obstruction (n=10, 15.1%). The primary reason for admission was respiratory failure (n=56, 84.8%). Pulmonary arterial hypertension (PAH) (n=19, 28.8%), acute respiratory distress syndrome (ARDS) (n=18, 27.2%) and sepsis (n=14, 21.2%) were observed during their clinical course. Twenty-six patients died (39.4%). Mortality-associated factors included the following: (i) baseline characteristics: history of mechanical ventilation, chronic upper airway obstruction and congenital heart disease; (ii) clinical course during paediatric intensive care unit stay: sepsis, catecholamine support, ARDS, PAH and nosocomial infection. In multivariate logistic analysis, history of mechanical ventilation, ARDS and PAH remained independently associated with death. ConclusionsThe mortality rate in critically ill DS children admitted for medical reasons is high and is predominantly associated with respiratory conditions.
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