Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/ijms232213776
Keywords
depression; antidepressants; endogenous compound; review
Funding
- National Natural Science Foundation of China [32071141]
- Natural Science Foundation of Shandong Province [ZR2019ZD34]
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This article investigates the antidepressant effects of multiple endogenous compounds and their targets, and discusses the prospects and challenges in the development of novel antidepressants.
Depression is a globally widespread disorder caused by a complicated interplay of social, psychological, and biological factors. Approximately 280 million people are suffering from depression worldwide. Traditional frontline antidepressants targeting monoamine neurotransmitters show unsatisfactory effects. The development and application of novel antidepressants for dissimilar targets are on the agenda. This review characterizes the antidepressant effects of multiple endogenous compounds and/or their targets to provide new insight into the working mechanism of antidepressants. We also discuss perspectives and challenges for the generation of novel antidepressants.
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