4.7 Review

Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles

Related references

Note: Only part of the references are listed.
Article Cell Biology

Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles

Bram Van den Broek et al.

Summary: This study demonstrates that HSPB8-enriched oligodendroglia secreted EVs have a supportive role comparable to native OL-EVs, functioning in controlling chronic inflammation and maintaining cellular homeostasis.

CELL COMMUNICATION AND SIGNALING (2022)

Article Biochemistry & Molecular Biology

circRNA Acbd6 promotes neural stem cell differentiation into cholinergic neurons via the miR-320-5p-Osbpl2 axis

Wen Li et al.

Summary: In this study, the researchers found that circAcbd6 in hippocampal exosomes promotes the differentiation of NSCs into cholinergic neurons via the miR-320-5p/oxysterol-binding protein-related protein 2 axis after fimbria-fornix transection.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Article Immunology

lincRNA-Cox2 Functions to Regulate Inflammation in Alveolar Macrophages during Acute Lung Injury

Elektra Kantzari Robinson et al.

Summary: This study reveals that lincRNA-Cox2 is a trans-acting long noncoding RNA that plays a role in regulating inflammation and maintaining homeostasis in the lung, particularly during acute lung injury. The researchers confirmed its role in gene expression regulation using genetic mouse models.

JOURNAL OF IMMUNOLOGY (2022)

Article Biotechnology & Applied Microbiology

Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression

Xian Xian et al.

Summary: This study found significantly higher expression levels of miR-9-5p in serum exosomes from patients with depression. Using experimental models, the researchers observed that miR-9-5p caused polarization of microglia and excessive release of inflammatory factors, exacerbating neuronal damage. The study also identified SOCS2 as a target of miR-9-5p. Overexpression of miR-9-5p suppressed SOCS2 expression and activated the JAK/STAT3 pathway. The findings suggest that the expression and secretion of miR-9-5p may serve as novel therapeutic targets for depression.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Article Neurosciences

Exosome-transported Long Non-coding Ribonucleic Acid H19 Induces Blood-brain Barrier Disruption in Cerebral Ischemic Stroke Via the H19/micro Ribonucleic Acid-18a/Vascular Endothelial Growth factor Axis

Jue Wang et al.

Summary: This study elucidates the relationship between the transport of lncRNA H19 by exosomes and blood-brain barrier breakdown induced by cerebral ischemic stroke.

NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex

Yanli Zhang et al.

Summary: Research has found that patients with autism spectrum disorder (ASD) have higher levels of miR-124, which may be related to brain development and social isolation. Animal models indicate that the miR-124 signaling pathway is involved in regulating myelination in brain regions associated with early social experiences, and could be a potential therapeutic target for neuropsychiatric disorders related to social neglect or social isolation.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Review Biochemistry & Molecular Biology

Exosomal MicroRNAs as Novel Cell-Free Therapeutics in Tissue Engineering and Regenerative Medicine

Eric Z. Zeng et al.

Summary: This article discusses the development of EV biogenesis and secretion pathways, as well as the role and application of microRNAs in EVs. It provides important information and knowledge for the future design of EVs with specific cargos in tissue repair and regeneration.

BIOMEDICINES (2022)

Article Medicine, Research & Experimental

M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice

Yongfang Li et al.

Summary: Research suggests that extracellular vesicles (EVs) derived from M2 microglia can promote white matter repair after cerebral ischemia through the direct targeting of Olig3 by miR-23a-5p. This finding provides a novel therapeutic strategy for white matter repair in stroke and demyelinating diseases.

THERANOSTICS (2022)

Article Immunology

lincRNA-Cox2 Functions to Regulate Inflammation in Alveolar Macrophages during Acute Lung Injury

Elektra Kantzari Robinson et al.

Summary: The text discusses the importance of lincRNA-Cox2 in regulating inflammatory responses and maintaining lung homeostasis. Studies have found that it is highly expressed in the lung and plays a role in regulating inflammation post-LPS-induced lung injury. Using mouse models, it has been confirmed that lincRNA-Cox2 has a broad impact on gene expression during acute lung injury and is crucial for immune responses and maintaining lung homeostasis.

JOURNAL OF IMMUNOLOGY (2022)

Article Biotechnology & Applied Microbiology

Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation

Yangping Li et al.

Summary: Using the CARP method, we discovered the dynamic regulation of circRNA in human oligodendroglia and the important role of the circRNA-miRNA-mRNA axis in promoting oligodendroglia development.

GENOME BIOLOGY (2022)

Article Cell Biology

Pathway-Focused Profiling of Oligodendrocytes Over-Expressing miR-125a-3p Reveals Alteration of Wnt and Cell-to-Cell Signaling

Davide Marangon et al.

Summary: MicroRNAs can influence multiple gene expressions and therefore lead to diverse functional consequences. The study reveals that over-expression of miR-125a-3p may impair oligodendrocyte maturation by regulating cell-cell interactions and the Wnt signaling pathway.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

Article Clinical Neurology

Characterizing blood‐based, microglial derived exosomes (MDEs) as biomarkers for Alzheimer’s disease

Charisse N. Winston et al.

Alzheimers & Dementia (2021)

Article Cell Biology

Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1

Dianquan Zhang et al.

Summary: This study found that M2 microglial exosomes (BV2-Exo) were internalized by neurons, attenuating neuronal apoptosis in response to ischemic injury and reducing infarct volume and behavioral deficits in ischemic mice. Exosomal miRNA-137 played a role in this neuroprotective effect by targeting Notch1.

AGING-US (2021)

Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Neurosciences

MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice

Emmanuelle Boscher et al.

Summary: Alzheimer's disease is a neurodegenerative disorder with complex genetic factors. Overexpression of miR-138 has been shown to replicate certain disease features in mice, affecting learning and memory as well as anxiety levels.

FRONTIERS IN NEUROSCIENCE (2021)

Review Neurosciences

Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System

Davide Marangon et al.

Summary: Myelin sheath is crucial for fast nerve conduction, formed by complex packaging of OL membranes. Study of OPCs and their behavior has advanced through experimental models helping understand myelination mechanisms in physiological and pathological conditions.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Cell Biology

Neuron-Oligodendrocyte Interactions in the Structure and Integrity of Axons

Greg J. Duncan et al.

Summary: Oligodendrocytes play a crucial role in myelinating axons, and disruptions in this relationship can lead to axonal dysfunction and neurodegeneration. Understanding the mechanisms behind demyelination and loss of oligodendrocytes is important in developing potential therapeutic strategies for disorders where oligodendrocyte support of axons is compromised.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients

Jacopo Angelini et al.

Summary: The study identified a significant increase of GPR17-expressing cells in multiple sclerosis (MS) patients, mainly accumulating in the normal appearing white matter (NAWM) with moderate inflammation. Additionally, two distinct subpopulations of GPR17-expressing oligodendroglial cells were found in the white matter of healthy controls and MS patients, characterized by different morphologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Neurosciences

Microglial Exosomes in Neurodegenerative Disease

Min Guo et al.

Summary: Microglia play a crucial role in neurodegenerative diseases, impacting pathological changes, neurogenesis, neuronal cell death, and synaptic interactions. Additionally, microglial exosomes have been found to contribute significantly to CNS diseases, serving as potential biomarkers for disease monitoring and as drug delivery vehicles for treating disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Oncology

Insights Into Exosomal Non-Coding RNAs Sorting Mechanism and Clinical Application

Yi Qiu et al.

Summary: Exosomes are natural nanoscale vesicles that can carry various bioactive molecules, including non-coding RNAs, which have been found to play important roles in biological processes such as tumorigenesis. Researchers are exploring the potential clinical applications of exosomal non-coding RNAs.

FRONTIERS IN ONCOLOGY (2021)

Article Cell Biology

Neural Stem Cell-Derived Exosomes Regulate Neural Stem Cell Differentiation Through miR-9-Hes1 Axis

Ping Yuan et al.

Summary: Exosomes, important components of the central nervous system microenvironment, are involved in intercellular communication by transferring bioactive molecules. Recent research shows that exosomes derived from neural stem cells can facilitate the differentiation of NSCs by transferring miR-9, which sheds light on potential cell-free therapeutic strategies for neurodegenerative diseases. Further studies identified Hes1 as a downstream target of miR-9 in this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Circular RNAs in the Central Nervous System

Meng-Lan Li et al.

Summary: Circular RNAs (circRNAs) are endogenous single-stranded RNAs with covalently closed loop structures, playing important biological functions in regulating protein functions and their own translation. They are enriched in the central nervous system (CNS) and play crucial roles in its development and diseases.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Cell Biology

Differential RNA packaging into small extracellular vesicles by neurons and astrocytes

Xuan Luo et al.

Summary: Differences in the molecular composition of sEVs released by primary neurons and astrocytes were observed, with neurons expressing more sEV-associated miRNAs than astrocytes. Only 20.7% of astrocytic miRNAs were loaded into sEVs, while 41.0% of neuronal miRNAs were loaded into sEVs, suggesting variations in cellular sorting mechanisms. Short RNA sequence motifs were identified on the differentially loaded or excluded miRNAs in sEVs, indicating a potential cell-type-independent mechanism for maintaining cellular miRNAs.

CELL COMMUNICATION AND SIGNALING (2021)

Review Biochemistry & Molecular Biology

Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience?

Julia Leschik et al.

Summary: Newborn neurons in the adult hippocampus are regulated by various factors, with elevated glucocorticoid levels leading to downregulation of adult neurogenesis. Adult neurogenesis is suggested to protect against stress-induced psychiatric diseases, serving as a resilience mechanism. Mechanisms underlying this include neurotransmitter dysregulation, immune pathways, and gut-brain axis influenced by microbiota changes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Neurosciences

From Junk to Function: LncRNAs in CNS Health and Disease

Rafaela Policarpo et al.

Summary: Recent advances in RNA sequencing technologies have revealed the significance of long non-coding RNAs (lncRNAs) in modulating protein-coding gene expression, especially in the central nervous system. Therefore, lncRNAs are gaining attention as potential novel therapeutic targets for brain disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Neurosciences

The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases

Luyao Huo et al.

Summary: Exosomes play a crucial role in intercellular communication in the central nervous system, regulating cellular function and contributing to both health and neurodegenerative diseases.

FRONTIERS IN NEUROSCIENCE (2021)

Article Medicine, Research & Experimental

M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124/STAT3 pathway after ischemic stroke in mice

Zongwei Li et al.

Summary: M2 microglial small extracellular vesicles decreased glial scar formation and promoted recovery after stroke through miR-124, inhibiting astrocyte proliferation and transforming them into neuronal progenitor cells. These vesicles also downregulated Notch 1 expression and upregulated Sox2 expression in astrocytes.

THERANOSTICS (2021)

Review Neurosciences

Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer's Disease

Zhiqi Song et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Clinical Neurology

Therapeutic Plasticity of Neural Stem Cells

Linda Ottoboni et al.

FRONTIERS IN NEUROLOGY (2020)

Review Neurosciences

Glia Crosstalk in Neuroinflammatory Diseases

Ada Bernaus et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Neurosciences

Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer's Disease

Emmanuelle Boscher et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Review Pharmacology & Pharmacy

MicroRNAs change the games in central nervous system pharmacology

Davide Marangon et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Neurosciences

Neuronal extracellular microRNAs miR-124 and miR-9 mediate cell-cell communication between neurons and microglia

Tatyana Veremeyko et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2019)

Article Pharmacology & Pharmacy

Exosomes From Astrocyte Processes: Signaling to Neurons

Arianna Venturini et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Cell Biology

Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection

Wazir Abdullahi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

MSC exosome works through a protein-based mechanism of action

Wei Seong Toh et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

Article Biochemistry & Molecular Biology

Long non-coding RNA H19 suppresses retinoblastoma progression via counteracting miR-17-92 cluster

Aihui Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Review Physiology

PHYSIOLOGY OF ASTROGLIA

Alexei Verkhratsky et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Neurosciences

Notch signaling and neuronal death in stroke

Thiruma V. Arumugam et al.

PROGRESS IN NEUROBIOLOGY (2018)

Review Oncology

Exosomal lncRNAs as new players in cell-to-cell communication

Mihnea Dragomir et al.

TRANSLATIONAL CANCER RESEARCH (2018)

Article Medicine, Research & Experimental

Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration

Guoku Hu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

Article Neurosciences

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities

Sebastien A. Gauthier et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

Review Pharmacology & Pharmacy

Microglial M1/M2 polarization and metabolic states

Ruben Orihuela et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Clinical Neurology

The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis

Sonja Koerner et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2016)

Review Immunology

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Jonathan D. Cherry et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Multidisciplinary Sciences

Quantitative and stoichiometric analysis of the microRNA content of exosomes

John R. Chevillet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

Mario Leonardo Squadrito et al.

CELL REPORTS (2014)

Article Cell Biology

Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

Mathilde Chivet et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

Article Hematology

MicroRNAs in Immune Response and Macrophage Polarization

Gang Liu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

Susan Carpenter et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication

Carsten Fruehbeis et al.

PLOS BIOLOGY (2013)

Article Clinical Neurology

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

Claudia Verderio et al.

ANNALS OF NEUROLOGY (2012)

Review Cell Biology

Chemokines in CNS injury and repair

Anne Jaerve et al.

CELL AND TISSUE RESEARCH (2012)

Article Biochemistry & Molecular Biology

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

Shayne A. Bellingham et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Cell & Tissue Engineering

Specific microRNAs modulate embryonic stem cell-derived neurogenesis

Anna M. Krichevsky et al.

STEM CELLS (2006)